Concanavalin A (ConA)
Derangements of liver tissue bioenergetics in Concanavalin A-induced hepatitis
... of ConA treatment, with attachment of leukocytes to the hepatic endothelium and activation of NK cells and ...the ConA-induced hepatic injury represents deleterious effects of inflammatory molecules ...
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Protective effect of galangin in Concanavalin A- induced hepatitis in mice
... on Concanavalin A (ConA)- induced hepatitis (CIH), a well-established animal model of immune-mediated liver injury, and to clarify the related ...by ConA challenge. Results indicated that galangin ...
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Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4+ T cells in mice
... Cytokeratin; ConA: Concanavalin A; DMEM: Dulbecco ’ s modified Eagle medium; DMSO: Dimethyl sulfoxide; ECL: Enhanced chemiluminescence; ELISA: Enzyme-linked immunosorbent assay; FBS: Foetal bovine serum; ...
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Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
... Hepatitis seriously threatens human health and daily life. It is caused by various factors such as viruses, drugs, chemicals, alcohol, genetic factors, or a patient’s own immune system. Currently, effective drugs in the ...
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Concanavalin A inhibits tissue factor coagulant activity
... Concanavalin A (con A) is a potent inhibitor of coagulant activity of native tissue factor. Coagulant activity is recovered by addition of alpha-methyl-D-glucoside to inhibited tissue factor. Inclusion of ...
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Concanavalin A induced liver injury triggers hepatocyte proliferation
... Concanavalin A (Con A) injection into mice leads to im- mune-mediated liver injury. We studied whether after Con A–induced liver injury, TNF- and IL-6–dependent signaling pathways known to be related to hepatocyte ...
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Studies of Two Subpopulations of Human Lymphocytes Differing in Responsiveness to Concanavalin A
... We have identified two populations of human lymphocytes differing in responsiveness to the plant mitogen concanavalin A (Con-A). When peripheral blood lymphocytes are passed through a nylon column a population of ...
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Fractionation of Fab glycosylated immunoglobulin G with concanavalin A chromatography unveils new structural properties of the molecule
... both ConA- and ConA+ IgG reacted with ConA indicating that the oligosaccharides attached to Asn 297 of Fc should be in the inside of the 3D protein structure and shielded from ...with ConA was ...
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Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts
... Results: In the present study, the anti‑hepatics and antioxidant activities of four D. heterophyllum extracts (i.e. petro‑ leum ether extracts, ethyl acetate extracts, n‑BuOH extracts, and water extracts) were conducted. ...
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Evidence for an Adenovirus Type 2-Coded Early Glycoprotein
... In this report, we present evidence that our 21K polypeptide is an Ad2-coded early glycopolypeptide, in that it can be labeled with [3H]glucosamine, it binds to concanavalin A ConA-Sepha[r] ...
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Changes in the immune system in experimental acanthamoebiasis in immunocompetent and immunosuppressed hosts
... In the early phase of inflammation, phagocytes produce pro-inflammatory cytokines IL-6, IL-8, IL-17 and IFN-γ that can initiate, exacerbate, and maintain the inflammatory process [27]. Antagonistic groups are ...
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ConA-based glucose sensing using the long-lifetime azadioxatriangulenium fluorophore
... lectin, Concanavalin A (ConA), with a high-affinity fluorescent ligand to which it ...of ConA to the fluorescent ligand can be engineered to respond to increasing concentrations of glucose, and this ...
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Inactivation of Herpes Simplex Virus by Concanavalin A
... HSV-1, McIntyre VR 3 strain, and 1312 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The infectivity of' herpes simplex virus type 1 HSV-1 was inactivated after treatm[r] ...
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Leishmania infantum specific IFN γ production in stimulated blood from cats living in areas where canine leishmaniosis is endemic
... Results: Most cats (n = 140) were L. infantum antibody negative and only 22% (n = 39) were positive. Only 9 and 2% of tested cats had a feline immunodeficency virus (FIV) infection or a feline leukemia virus (FeLV) ...
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Characterization of an African trypanosome mutant refractory to lectin-induced death.
... lectin concanavalin A (conA) leads to alteration in cellular DNA content, DNA degradation, and surface membrane ...a conA-refractory Trypanosoma brucei ...to conA killing, with a median lethal ...
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Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice
... inflammation and shows strong anti-inflammatory effects. The study reported here investigated whether ghrelin exerted any effect on Con A-induced immune hepatitis and its mechani[r] ...
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Lectin of Concanavalin A as an anti-hepatoma therapeutic agent
... The Con A-induced autophagic cell death with necrosis can initiate a tumor cell-specific immune response, but although Con A can initiate the immune response in a tumor cell in a non-spe[r] ...
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Quantitative Binding of 125I-Concanavalin A to Normal and Transformed Cells
... Although we do not know enough about the actual differences in cell surfaces between transformed and normal cells to distinguish clearly a mechanism for agglutination, we have shown that[r] ...
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Overcoming the aggregation problem : a new type of fluorescent ligand for ConA-based glucose sensing
... lectin Concanavalin A (ConA) have displayed significant potential to serve in continuous glucose monitoring ...and ConA (presenting multiple binding sites) in free ...µM ConA, the fluorescence ...
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Intracellular free radical production by peripheral blood T lymphocytes from patients with systemic sclerosis: role of NADPH oxidase and ERK1/2
... bromodeoxyuridine; conA: concanavalin A; DCFH-DA: 2 ′ , 7 ′ -dichlorodihydrofluorescin diacetate; DPI: diphenylene iodonium; FCS: fetal calf serum; FITC: fluorescein isothiocyanate; ERK: extracellular ...
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