controlled human malaria infection
Alterations of blood coagulation in controlled human malaria infection
... of malaria on humans are difficult to conduct in malaria patients due to frequent co-infections and widely varying clinical mani- festations, time of infection and levels of ...healthy malaria ...
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Changes in total and differential leukocyte counts during the clinically silent liver phase in a controlled human malaria infection in malaria naïve Dutch volunteers
... Controlled Human Malaria Infection (CHMI) is a well- established clinical model that was developed for the evaluation of candidate malaria vaccines and drugs ...by malaria ...
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Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose finding trial in two centres
... cines, human challenge models are of particular interest. Controlled human malaria infection (CHMI) with Plas- modium falciparum is among the best studied challenge models and has paved ...
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Safety and efficacy after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model
... of malaria is estimated to be around 198 million clinical cases resulting in ...falciparum malaria can efficiently and repro- ducibly be achieved in the Controlled Human Malaria ...
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Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya
... CHMI: Controlled human malaria infection; DefExp: Definite prior exposure to ...HIV: Human Immunodeficiency Virus; IV: Intravenously or intravenous; KEMRI: Kenya Medical Research ...
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Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report
... underwent controlled human malaria infection (CHMI) by the bites of five ...falciparum infection, ii) rhinovirus infection, iii) unidentified pathogens, iv) hyper-immunization ...
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Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria naïve volunteers: effect of injection volume and dose on infectivity rates
... Controlled human malaria infection (CHMI) has facilitated progress in research and development of vaccines and drugs providing the possibility to infect volunteers under controlled ...
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Diagnosis and treatment based on quantitative PCR after controlled human malaria infection
... Subjects were asked to keep a diary recording symptoms while followed up for adverse events (AEs) on an out- patient basis once or twice daily starting on day 5 after challenge infection until day 21. Adverse ...
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A controlled human malaria infection model enabling evaluation of transmission blocking interventions
... confinement, participants were monitored for up to 24 days and a sec- ond dose of piperaquine phosphate (960 mg) was administered to par- ticipants who experienced recrudescence. Gametocyte development was measured from ...
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Increased sample volume and use of quantitative reverse transcription PCR can improve prediction of liver to blood inoculum size in controlled human malaria infection studies
... improve the accuracy of LBI estimation in those trials where early timepoints (up to D7.5) were frequently nega- tive by standard assays [8,9]. In studies where early time- points are qualitatively positive by Oxford ...
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Antibody Biomarkers Associated with Sterile Protection Induced by Controlled Human Malaria Infection under Chloroquine Prophylaxis
... FIG 1 CPS immunization induces broad and variable humoral responses against P. falciparum antigens. (A) Plasma samples from 38 CPS-immunized volunteers from 3 clinical trials (n ⫽ 9 from study 1, n ⫽ 5 from study 2, and ...
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Dichotomous miR expression and immune responses following primary blood-stage malaria
... Plasmodium infection revealed by our controlled human malaria infection study has important practical implica- ...a malaria-naive population will mount an impaired immune ...
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Use of gene expression studies to investigate the human immunological response to malaria infection
... falciparum infection, except two that related to Plasmodium vivax ...with malaria ‘naturally’ in the field (n = 13, 57%), however some related to controlled human malaria ...
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Cardiac complication after experimental human malaria infection: a case report
... A 20-year old, healthy female volunteer (medical student) participated in a double blind randomized phase I condi- tional IIa trial with the candidate malaria vaccine PfLSA-3- rec in 2007-2008. The volunteer's ...
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Annotation and characterization of the Plasmodium vivax rhoptry neck protein 4 (Pv RON4)
... natural human malaria infection, sugges- ting their exposure to the immune system during host cell invasion as has been proposed for other im- portant antigens, such as merozoite surface proteins ...
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A stochastic model for the probability of malaria extinction by mass drug administration
... against malaria transmis- sion agree that without some other sustained change, such as improved vector control, the effects of MDA on prevalence are likely to be transient ...of malaria by MDA on islands ...
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Monitoring mitochondrial inner membrane potential for detecting early changes in viability of bacterium-infected human bone marrow-derived mesenchymal stem cells
... Even though the incidents of microbial contamination of cell products seem to be rare, the risk of contamina- tion is a critical issue since the consequences to patient health may be unpredictable and even devastating ...
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A model of Plasmodium vivax concealment based on Plasmodium cynomolgi infections in Macaca mulatta
... the malaria disease ...during infection correlates with sever- ity of the infection in four out of five of the macaques in the ...during infection, may correlate with disease presentation and ...
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Use of Intravenous Immunoglobulins for Prophylaxis or Treatment of Infectious Diseases
... high-titered human polyclonal RSV IVIg (Respigam) does not significantly reduce the incidence of RSV ...RSV infection severity, manifested as reduction in hospitalization rate (P ⫽ ...RSV infection ...
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Comparative Analysis on Malaria, Typhoid and Hepatitis B Virus Infections in Okigwe and Udo-Mbaise of IMO State, Nigeria
... of Malaria, Typhoid and Hepatitis B virus infections were carried out in some parts of Imo State namely; Okigwe and Udo-Mbaise using both culture and serological ...examined. Malaria prevalence in Okigwe ...
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