COX-2 inhibitor
The Role of Celecoxib as a Cox-2 Inhibitor Increasing the Radiosensitivity of Tumor Tissue
... for COX-2, there might be other factors involved ...Z-DEVD-FMK inhibitor and prostaglandin E2.In contrast, BCL-2, bax, c-Myc, Fas and Fas-ligand showed minor ...of COX-2, which ...
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Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines
... selective COX-2 inhibitor, NS398 (N-[2-(Cyclohexyloxy)-4-nitrophenyl] methanesulfonamide) acquired from Sigma Aldrich (Sigma Aldrich, Saint Louis, MO, ...the COX-2 ...
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YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer
... and COX-2 were synergistic in apoptosis of these cells, we assessed the effects of shRNA targeting YAP and COX-2 on apoptosis sensitivity in HCT8 and 15/Tax ...or COX-2 ...
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Significant Combination of Preferential COX-2 Inhibitor and Non-Anticholinergic Spasmolytic Used In Labor Augmentation
... a COX-2 inhibitor and Drotaverine HCl, an antispasmodic agent with non-anticholinergic action as a suitable choice to augment the labor over the other ...
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ANTI INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX 2 INHIBITOR WITH CONVENTIONAL NSAIDs
... selective COX- 2 inhibitor has high cardiovascular side effects, with low GI side effects, as compare to the conventional NSAID and it is proved that low dose of any drugs is always good for the ...
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Complete remission of pancreatic head desmoid tumor treated by COX 2 inhibitor—a case report
... Case presentation: Herein, we report a 57-year-old woman who presented with recurrent epigastric pain and weight loss. An abdominal computed tomography scan showed an approximately 10-cm mass over the pancreatic head ...
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SYNTHESIS OF N (ALKYL OR ARYL) 2 (1H BENZOTRIAZOL 1 YL) ACETAMIDES AS SELECTIVE COX 2 INHIBITOR
... Thus, for aliphatic amine we have used ethyl chloroacetate instead of chloroacetyl chloride as side product formed in this reaction is ethanol and not HCl , final product gets precipitated out in the reaction flask ...
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Microarray analysis of NSAIDs-treated cardiomyocytes to search for genes involved in COX-2 inhibitor cardiotoxicity
... selective COX-2 NSAID, interrupted excitation contraction coupling in cardiomyocytes (Baek et ...chain 2 cardiac muscle isoform, tropomyosin α-1 chain, myosin light chain 3, cardiac actin isoforms, ...
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NS 398 induces caspase dependent, mitochondria mediated intrinsic apoptosis of hepatoma cells
... of COX-1 and inducible form of ...of COX-2 was known to be associated with neoangiogenic, antiapoptotic, and invasive or me- tastatic property in certain cell types [7-11], COX-2 has ...
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Abstract
... after 2−week administra− tion of 25 mg, b.i.d. rofecoxib, a COX−2 inhibitor ...for 2 years, there was no difference in regression of intestinal metaplasia considered to be a ...
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Cyclooxygenase-2-Dependent Bronchoconstriction in Perfused Rat Lungs Exposed to Endotoxin
... formation and LPS-induced bronchoconstriction were prevented by treatment with the unspecific COX inhib- itor acetyl salicylic acid, the specific COX-2 inhibitor CGP-28238, dexamethasone[r] ...
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Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP 1 human macrophages: a possible mechanism for increased cardiovascular risk
... of COX-2 on platelets and the effect on overall platelet function are still matters of controversy ...only COX- 1, COX-2 can be readily induced under conditions of vascular injury ...of ...
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The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer
... the COX-2 inhibitor, celecoxib, on (1) proliferation and apoptosis in human ovarian cancer cell lines and primary cultures of ovarian cancer cells, and (2) inhibition of tumor growth in a ...
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Cyclooxygenase 1–selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus
... Postmortem analysis was performed to identify pathologies responsible for the observed mortality in neonates born to dams chronically treated with a COX-2 inhibitor (on gestation days 15–18). Lungs, ...
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Activation of Guanylate Cyclase-C With Heat-Stable Enterotoxin Fails to Potentiate Celecoxib-Induced Reduction in Colorectal Cancer Cell Growth in Vitro
... for COX-2 inhibition in cancer treatment remain unclear, as COX-independent anti-neoplastic and pro-apoptotic effects following NSAID administration have been observed (Sade, Tuncay, Cimen, Severcan, ...
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Effect of COX-2 inhibition on tendon-to-bone healing and PGE2 concentration after anterior cruciate ligament reconstruction
... selective COX-2 inhibitors, some authors describe no effect on tendon healing ...selective COX-2 inhibi- tor treatment at later time points does not negatively affect tendon stability ...late ...
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Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients
... of COX-2 inhibitor ...of COX-2 hypersensitivity did not differ between the patients diagnosed by careful his- tory only versus those in which the diagnosis was con- firmed by ...
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BISPHENOL A ENHANCES GROWTH OF Hep G2 CANCER CELLS BY UPREGULATING EXPRESSION OF PRO – INFLAMMATORY AND PRO – ANGIOGENESIS PROTEINS
... Akt, COX-2, HIF-1α and VEGF, which are generally found to aid cancer ...a COX-2 inhibitor, reduced the cell viability in HepG2 cells and treatment with Meloxicam was found to down ...
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Original Article Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells
... (COX-2) inhibitor, can attenu- ate proliferation, migration, invasion and MMP-14 expression in pancreatic cancer cells PANC-1 and the possible anti-tumor mechanism of ...of COX-2 and ...
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Perioperative celecoxib administration for pain management after total knee arthroplasty – A randomized, controlled study
... Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor and an effective analgesic for acute postoperative pain [16]. Although pre-operative non-selective NSAID use increases the risks of bleeding ...
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