CpG islands (CGIs)
G9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors
... We recently observed that in adult human hematopoietic stem and progenitor cells (HSPCs), H3K9me2 chromatin territories are absent in primitive cells and are formed de novo during lineage commitment [6]. In committed ...
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CpG islands’ clustering uncovers early development genes in the human genome
... of CpG-island clusters were found within homeobox genes (related to development), in agreement with previous observations ...141 CpG-islands are related to homeobox genes (HOXa,c) and neural ...
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Genome wide analysis of CpG islands in some livestock genomes and their relationship with genomic features
... A systematic comparative genomic analysis of CGIs and CGI density was conducted in the do- mestic even-toed ungulate genomes. The number of CGIs and the CGI density showed low variations in these genomes. This may be due ...
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Orphan CpG islands identify numerous conserved promoters in the mammalian genome
... CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of most genes and often lack DNA ...species CpG density correlates positively with the degree of H3K4 trimethylation, ...
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Analysis of the Promoter Region, Motif and CpG Islands in AraC Family Transcriptional Regulator ACP92 Genes of Herbaspirillum seropedicae
... and CpG islands are the most important ...and CpG islands in AraC family transcriptional regulator ACP92 genes of Herbaspirillum ...are CpG Island which implies that the regulation of ...
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Preservation of methylated CpG dinucleotides in human CpG islands
... methylated CpG dinucleo- tides in human CpG islands” by ...for CpG islands, although it can no longer be viewed as null hypothesis, because we know that a lot of noncoding sequences are ...
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CpGIMethPred: computational model for predicting methylation status of CpG islands in human genome
... the CpG island methylation by incorporat- ing additional features and effectively selecting and dec- orrelating the ...of CpG islands; (2) by incorporating the information regarding the nucleosome ...
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The properties of CpG islands in the putative promoter regions of human immunoglobulin (Ig) genes
... the CpG islands has gained great interests. Whole genome CpG island libraries have been prepared for human (Cross et ...of CpG island- associated ...species, CpG islands are not ...
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Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer
... CpG islands are DNA sequences having high CpG ra- tios and GC ...of CpG islands are lo- cated around transcription start site of protein coding ...with CpG islands have ...
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CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands
... a CpG dinu- cleotide, and four of these five motifs were also strongly biased or exclusive for either cell type, whereas the fifth was of low complexity (Additional file 1: Table S3); these results demonstrate ...
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Transcription and chromatin determinants of de novo DNA methylation timing in oocytes
... Results: Given the predominant role of transcription, we sought to investigate whether transcription timing is rate limiting for de novo methylation and determines the asynchrony of methylation events. Therefore, we ...
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Establishment of Methylation Sensitive Suppression Subtraction Hybridization Analysis and Isolation Of 5’cpg Islands Fragments in Chinese Fir Genomic DNA
... construction CpG islands. By now the reported method used to con- struct CpG islands database is loaded down with trivial details and is difficult to screen effective ...construct CpG ...
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Variation in 5 hydroxymethylcytosine across human cortex and cerebellum
... cortex: OR = 1.78, P = 3.93E-262; cerebellum: OR = 1.86, P <2.53E-294), and locations outside of CG-rich regions (prefrontal cortex: OR = 1.62, P <2.53E-294; cerebellum: OR = 1.68, P <2.53E-294) (Table 1, Fig. ...
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Diverse interventions that extend mouse lifespan suppress shared age associated epigenetic changes at critical gene regulatory regions
... Background: Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging “ clock ” , a robust biomarker of aging. However, while genetic, dietary ...
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Epigenetic change in e cardherin and COX 2 to predict chronic periodontitis
... of CpG islands in the E-Cadherin and COX-2 genes in peri- odontitis patients occurs more frequently than in the healthy control group, but less frequently than in the breast cancer patients as supported by ...
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Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer
... sites, CpG islands, and DNase- hypersensitive sites, all features that are frequently associated with structurally open transcription regulatory regions of a ...and CpG islands (27, ...
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Hepatitis B Virus Replication Induces Methylation of both Host and Viral DNA
... Increased DNMT expression leads to methylation of host CpG islands. Using the same experimental conditions, a series of cell culture experiments were designed to investigate if ex- FIG. 1. DNMTs are ...
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Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver
... Bioinformatics. We downloaded coordinates of RefSeq genes, CpG islands, and other annotation tables for the October 2003 mouse genome freeze from the UCSC genome project website. In the present study, we ...
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DNA methylation analysis of phenotype specific stratified Indian population
... 269 CpG islands in Pitta prakriti, followed by Vata prakriti with 175 probes representing 139 CpG islands and finally Kapha prakriti with 23 probes and 19 CpG islands (Figure 1A) ...
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Thesis.pdf
... The transcription factor occupancy theory is a possible explanation for methylation patterning that occurs in response to specific environmental exposures (Sanders et al., Rojas et al., Martin et al.). Under this theory, ...
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