CpG sites
Identifying fenofibrate responsive CpG sites
... (CpG) sites responsive to treatment with ...450,000 sites in pedigree members, prior to and after 3 weeks of ...responsive sites by analyzing the pre- and posttreatment methylation changes ...
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Polymorphisms involving gain or loss of CpG sites are significantly enriched in trait-associated SNPs
... of CpG sites, the basis of DNA modification such as methylation and ...of CpG sites and were defined as CpG site related SNPs (cgSNPs) in this ...of CpG sites were ...
10
Individualized analysis reveals CpG sites with methylation aberrations in almost all lung adenocarcinoma tissues
... (DM) CpG sites in cancer tissues compared with normal controls using various statistical methods such as the Shannon entropy based method QDMR [9], empiri- cal Bayes model DiffVar [10] and T test ...DM ...
9
CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing
... two CpG sites in close proximity is most likely the result of a shared, differentially methyl- ated, region that is modified from the nearby methyltrans- ferase binding ...cg10501210 sites, located ...
5
Quantification of global mitochondrial DNA methylation levels and inverse correlation with age at two CpG sites
... 54 CpG sites in mitochondrial genome and that the level of the methylation was variable among different ages (18-91 ...these CpG sites (M1215 and M1313) showed stronger correlation between ...
6
Individual CpG sites that are associated with age and life expectancy become hypomethylated upon aging
... reproducible DNA methylation (DNAm) changes at specific sites in the genome [4–8]. About 60% of these age-associated CG dinucleotides—so called “CpG sites”—become hypomethylated upon aging, whereas ...
6
Detection and analysis of CpG sites with multimodal DNA methylation level distributions and their relationships with SNPs
... of CpG sites and only considered CpG sites that physically overlapped with ...identify CpG sites with multimodal distribu- tions (mmCpGs) [5], which was implemented in the Bio- ...
6
Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths
... We searched for genomic regions (in a window of 1000 bases) where the DNA methylation was associated with the emergence of dimensional psychopathology in youths in a coordinated manner. We identified 90 DMRs that were ...
16
Evolutionary Divergence of Exon Flanks: A Dissection of Mutability and Selection
... nucleotide sites at exon flanks into four distinct types on the basis of the local CpG context: sites preceded by a C and followed by a G (postCpreG), sites followed by a G but not preceded by ...
5
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
... individual CpG sites with high reso- lution, and is a considerable improvement on the previous Golden-Gate methylation assay, this methodol- ogy still has some ...the CpG Islands with high likelihood ...
11
Epigenetic regulation of inflammation in localized aggressive periodontitis
... Previous studies have focused on analyzing DNA methylation of inflammatory cytokines and TLR2 genes from gingival biopsies [10, 13, 31–33]. Since we are in- terested in analyzing predisposition to LAP as it relates to ...
10
A proximal conserved repeat in the Xist gene is essential as a genomic element for X inactivation in mouse
... Furthermore, CpG sites in the promoter region of paternal Xist , which are essentially unmethylated in the extraembryonic tissues of the wild-type female embryo, acquire a significant level of methylation ...
8
Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
... the CpG sites in the Ndrg2 promoter were mostly hypermethylated in gastric cancer cell lines and primary tumors, whereas those in normal gastric tissues remained ...
16
Original Article Aberrant RASSF5 gene transcribed region hypermethylation in pediatric hepatoblastomas
... five CpG sites in the gene body region of RASSF5 from each sample, and the degree of methylation of all five sites was significantly higher in the HB samples than in the normal liver ...CpGs ...
6
DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics
... mouse) CpG sites in the IFNγ gene promoter region (CpG −186 and −54, Figure 1) between CD4+ T lymphocytes and buccal cells in a select cohort of allergic- sensitized children and adults with ...
9
The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study
... 3811 CpG sites in the promoter regions of these 519 genes were selected for the screening in the derivation ...the CpG sites is illustrated in ...
9
Vitamin D and the promoter methylation of its metabolic pathway genes in association with the risk and prognosis of tuberculosis
... 310 CpG sites in five candidate ...methylated CpG sites between cases and controls; ...the CpG sites that remained significant after the Bonferroni correction as the biomarkers, ...
12
Methylation of the imprinted GNAS1 gene in cell free plasma DNA : equal steady state quantities of methylated and unmethylated DNA in plasma
... several CpG sites in the GNAS1 imprinted region, and to directly examine the representation of methylated and unmethylated DNA molecules in cfp DNA in detail, we employed bisulfite ...
17
DNA methylation in schizophrenia: progress and challenges of epigenetic studies
... specific CpG sites in SLC6A4 (which encodes a serotonin transporter, one of the main targets of anti- depressants) and human leukocyte antigen complex group 9 gene (HCG9, which is located within the MHC ...
13
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects
... trimodal sites in chromosome 6 ...trimodal sites in these spe- cific locations. This small subset of trimodal sites observed here is clearly due to strong genetic variations as this ef- fect does not ...
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