CREB-A
Activation of CREB/ATF Sites by Polyomavirus Large T Antigen
... Since NT is well known to affect cell cycle, we first tested its ability to activate the ⫺ 37/ ⫺ 33 cyclin A promoter. As shown in Fig. 4B, NT lacked activity. When expressed at higher levels, it appeared to be toxic, ...
11
CREB and CREB-binding proteins play an important role in the IE2 86-kilodalton protein-mediated transactivation of the human cytomegalovirus 2.2-kilobase RNA promoter.
... D CREB fusion pro- tein and IE2 86 ...D CREB, a protein that contains a deletion of amino acids 88 to 101 ...D CREB phos- phorylated by protein kinase A in vitro does bind more strongly to IE2 86 ...
12
Changes in CREB Activity and BDNF Plasma Levels in Patients with Post-Traumatic Stress Disorder (PTSD)
... of CREB protein is crucial for studying CREB mediated regulation of gene ...that CREB as a transcription factor activated by affective, neurodegenerative disorders and some neurotransmitters such as ...
8
The Role of CREB in the Liver and Adipose Tissue
... of CREB, which in addition to CREB are the activating transcription factor 1 (ATF1) and cAMP- responsive element modulator (CREM), and these two proteins can also mediate transcriptional response to cAMP ...
116
Original Article CREB is upregulated in hepatic encephalopathy and contributes to the neuroprotection against neuroinflammation
... whether CREB affect neurological decline in a hepatic encephalopathy animal model under trial ...of CREB was significantly elevated in AOM-treated mice ...and CREB were significantly ...that ...
8
Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target
... the CREB-dependent induction of miR-373 promotes pancreatic tumor growth in vitro and in vivo ...cells CREB has been shown to suppress the expression of the RNA-editing enzyme ADAR1 in vitro and in situ, ...
12
The calcium/calmodulin regulated kinase cascade in learning and memory
... activating CREB and transcription in ...to CREB phosphorylation (D eisseroth et ...impair CREB mediated gene ...and CREB activation is a function o f the frequency o f hippocampal burst firing ...
171
Involvement of HTLV I Tax and CREB in aneuploidy: a bioinformatics approach
... The Tax oncoprotein is considered the cause for mitotic aberrations in HTLV-I infected cells. In addition to bind- ing checkpoint factors and interfering with the MSC func- tion, we propose a mechanism by which Tax ...
21
Anxiolytic effects of Formononetin in an inflammatory pain mouse model
... as CREB binding proteins ...inhibit CREB-mediated gene transcription by binding to ...that CREB-dependent transcription is essential for both long-lasting forms of synaptic plasticity and long-term ...
12
Protein-protein interactions of transcription factor CREB 1
... unless CREB and/or the catalytic subunit of Protein Kinase A (cPKA) are overexpressed (Masson et ...the CREB protein ...homodimeric CREB compared to extracts from differentiated F9s (DF9s) ...
197
APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice
... As data indicate that the APOE4-induced risk for AD is significantly greater in females compared to males in both humans and APOE-TR mice [35,53-55], female EFAD-Tg mice [48] were used in this study to identify the ...
17
Original Article Functional cross-talk between cAMP and ERK1/2 pathway promotes proliferation of somatotropinomas in a B-Raf and C-Raf dependent manner
... and CREB, levels of cyclinsD1 and D3, B-Raf and C-Raf activity, together with B-Raf/C-Raf binding were ...and CREB, and increased levels of cyclinsD1 and ...
13
Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
... sequesters CREB-binding protein (CBP), an important activator of CREB, to de- crease the expression of CREB target genes [33, ...hanced CREB-dependent transcription of BDNF that could be ...
9
<p>Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis</p>
... Figure 3 ANS-induced mouse osteoarthritis. (A) X-ray of the knee from the control ANS-induced mice. (B) Safranin O and fast green staining of cartilage tissues from mice in the CON and ANS groups. (C) ...
10
Effect of Hippocampal CREB Deletion on Models of Anxiety, Depression, and Antidepressant Response
... on CREB, as well as the mechanisms by which it is activated, and in turn, activates transcription of its target ...of CREB demonstrate striking similarity, with a difference of only one to two amino acids ...
144
<p>Inhibition of Skp2 Sensitizes Chronic Myeloid Leukemia Cells to Imatinib</p>
... Wild-type, CREB and Skp2 knockdown K562 cells were fi rst treated with Imatinib individually to assess the cell survival ...with CREB or Skp2 stable knockdown signi fi - cantly decreased with Imatinib ...
11
Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human Immunodeficiency Virus Type 1 Transcription in Cells of the Monocyte/Macrophage Lineage
... ATF/ CREB family, we proceeded to determine whether an adjacent ATF/CREB binding site could affect C/EBP protein binding to C/EBP site ...of CREB-1 and C/EBP appear to heterodimerize and bind to a ...
15
Original Article MicroRNA-181 inhibitor protects against sevoflurane-induced hippocampal apoptosis and memory impairment
... electrophoresis and then transblotted onto polyvinylidene difluoride membranes (Millipo- reCorp., Bedford, MA). The membranes were blocked and then incubated with appropriate primary antibodies overnight at 4°C. Primary ...
8
Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133
... of CREB and a constitutively active PKA (25, 31) to- gether with b -galactosidase inhibited the proliferation of these activated ...with CREB alone, PKA alone, or CREB-Ala 133 (which lacks the Ser ...
8
Minocycline upregulates cyclic AMP response element binding protein and brain-derived neurotrophic factor in the hippocampus of cerebral ischemia rats and improves behavioral deficits
... weeks. CREB and pCREB were examined by Western blotting, reverse transcription polymerase chain reaction, and immuno- ...(P=0.0016). CREB, pCREB, and BDNF were downregulated after permanent bilateral ...
10