CsA, cyclosporine
Clinical utility of cyclosporine (CsA) ophthalmic emulsion 0.05% for symptomatic relief in people with chronic dry eye: a review of the literature
... of cyclosporine (CsA) ophthalmic emulsion ...with CsA, but variable results with symptomatic improvement, possibly due to patient tolerance of CsA, similar comforting effect with artificial ...
10
Clearing the complexity: immune complexes and their treatment in lupus nephritis
... Abbreviations: AZA, azathioprine; bid, twice daily; CRF, chronic renal failure; CRR, complete renal response; CSA, cyclosporine A; CYC, cyclophosphamide; eSRD, end s[r] ...
12
Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study
... Abbreviations ANA: Antinuclear antibody; anti-dsDNA: Anti-double-stranded DNA antibody; BILAG: British Isles Lupus Assessment Group; BlyS: B-lymphocyte stimulator; CsA: Cyclosporine A; C[r] ...
14
Gastrointestinal tuberculosis following renal transplantation accompanied with septic shock and acute respiratory distress syndrome: a survival case presentation
... Ciprofloxacin; CsA: Cyclosporine; CT: Computed tomography; ETH: Ethambutol; FLU: Fluconazole; GCS 3: Glasgow Coma Scale; GITB: Gastrointestinal tuberculosis; Hb: Hemoglobin; HC: Hydrocortisone; HR: Heart ...
7
Systems toxicology: real world applications and opportunities
... EMBL; CsA, cyclosporine A; EBI, European Bioinformatics Institute; EMBL, European Molecular Biology Laboratory; EURL ECVAM, European Union Reference Laboratory for Alternatives to Animal Testing; GIVIMP, ...
13
Efficacy and safety of calcineurin inhibitor treatment for IgA nephropathy: a meta-analysis
... Two researchers (GYC and YHS) performed a systematic literature search using the PubMed, Embase, Science Citation Index, Ovid evidence-based medicine, Chinese Biomedical Literature (CBM) and Chinese science and ...
9
Colon-targeted delivery of cyclosporine A using dual-functional Eudragit<sup>®</sup> FS30D/PLGA nanoparticles ameliorates murine experimental colitis
... The goal of colon-targeted delivery in UC therapy is to deliver the maximum amount of drug to the inflamed colon, while minimizing systemic drug absorption and unwanted side effects in the upper regions of the GIT. In ...
16
Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus
... 10), cyclosporine A (CsA; n = 6), tacrolimus (FK506; n = 1), leflunomide (LEF; n = 2), myco- phenolate mofetil (MMF; n = 8), methotrexate (MTX; n = 8)), and 59 were receiving an antimalarial drug (chloro- ...
11
Cyclophilins: The Structure and Functions of an Important Peptidyl-prolyl Isomerase
... Cyclophilins can act as foldases or chaperones. They possess peptidyl-prolyl isomerases (PPIase) activity, which is inhibited by cyclosporine A (CsA). Their PPIase activity makes them be able to accelerate ...
6
Mesenchymal stem cells overexpressing IL-35: a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance
... In 2002, Bartholomew et al. [36] observed that MSCs could suppress lymphocyte proliferation in vitro and in vivo. Administration of MSCs led to prolonged skin graft survival in baboons when compared to control animals ...
8
Regression of cardiac growth in kidney transplant recipients using anti-m-TOR drugs plus RAS blockers: a controlled longitudinal study
... (SRL) led to regression of pressure load-induced LVH in animal models [3-5]. In addition, nonrandomized con- trolled trials have shown that conversion from calcineurin inhibitors (CNI) to SRL may regress LVH in KT ...
8
Metastatic Merkel cell carcinoma and myasthenia gravis: contraindication for therapy with immune checkpoint inhibitors?
... Case presentation: A 61-year-old woman with a history of MG since 2005 was treated with azathioprine and pyridostigmine after thymectomy. In March 2016, she was diagnosed with MCC. Six months later the tumor had ...
6
Invasive mycoses in patients with connective tissue disease from Southern China: clinical features and associated factors
... (1/197) in SSc, and 0.4% (3/728) in PM/DM. Proven in- fection accounted for 18.8% (6/32) of the cases, and probable infection for 81.3% (26/32). All patients were of Chinese Han ethnicity. Of the 32 patients enrolled, ...
9
Efficacy and safety of cyclosporine a for patients with steroid-resistant nephrotic syndrome: a meta-analysis
... of CsA vs. CYC and CsA vs. TAC. CsA treatment results in a higher TR when compared to ...The CsA group also had a higher CR than the CYC group, although this difference was not ...that ...
8
Drug-induced gingival hyperplasia: a retrospective study using spontaneous reporting system databases
... Drug-induced gingival hyperplasia (DIGH) is a peri- odontal side effects of certain drugs, causing swelling, bleeding, and problems with chewing, aesthetics, and pronunciation. In more severe cases, it can cause high ...
11
Clinically relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion
... Methods: Isolated Langendorff-perfused rat hearts were treated sequentially with 5 nM Iso and 30 μ M Ade followed by different durations of washout prior to 30 min global ischaemia and 2 hrs reperfusion. Reperfusion ...
13
Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America
... Juvenile dermatomyositis (JDM) is a systemic auto- immune disease in children and adolescents character- ized by a vasculopathy that primarily affects skin and muscle but may involve the lungs, heart, gastrointes- tinal ...
8
Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
... Finally, cyclosporine A (CsA) was used as an illustrative case to support applicability of zebrafish embryo in hepatotoxicity testing by comparing CsA-induced gene expression between [r] ...
124
IL 10 plays a key role in the regulation of TNF alfa mRNA expression during dna fragmentation in the nephrotoxicity generated by amphotericin b and cyclosporine
... that CsA can also damage renal tubular cells by indirect mechanisms, inducing the production of osteopontin, which promotes inflammation that injures renal ...
9
Mesenchymal stem cell-based therapy in kidney transplantation
... and cyclosporine-resistant GVHD with ...low-dose cyclosporine A (CsA) reversed the protective influence of CsA and accelerated allograft re- jection ...low-dose CsA, MSCs could not ...
7