CsA, cyclosporine A
Clearing the complexity: immune complexes and their treatment in lupus nephritis
... Abbreviations: AZA, azathioprine; bid, twice daily; CRF, chronic renal failure; CRR, complete renal response; CSA, cyclosporine A; CYC, cyclophosphamide; eSRD, end s[r] ...
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Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study
... Abbreviations ANA: Antinuclear antibody; anti-dsDNA: Anti-double-stranded DNA antibody; BILAG: British Isles Lupus Assessment Group; BlyS: B-lymphocyte stimulator; CsA: Cyclosporine A; C[r] ...
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Systems toxicology: real world applications and opportunities
... EMBL; CsA, cyclosporine A; EBI, European Bioinformatics Institute; EMBL, European Molecular Biology Laboratory; EURL ECVAM, European Union Reference Laboratory for Alternatives to Animal Testing; GIVIMP, ...
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Colon-targeted delivery of cyclosporine A using dual-functional Eudragit<sup>®</sup> FS30D/PLGA nanoparticles ameliorates murine experimental colitis
... Results: PNPs exhibited a burst drug release of .60% at pH 1.2 (stomach pH) in 0.5 h, which can lead to unwanted systemic absorption and side effects. ENPs effectively inhibited the burst drug release at pH 1.2 and 6.8 ...
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Clinically relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion
... It is now recognized that opening of the mitochondria permeability transition pore (MPTP) plays a key role in me- diating the irreversible damage of the myocardium during reperfusion [9] and that a range of interventions ...
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Efficacy and safety of calcineurin inhibitor treatment for IgA nephropathy: a meta-analysis
... Two researchers (GYC and YHS) performed a systematic literature search using the PubMed, Embase, Science Citation Index, Ovid evidence-based medicine, Chinese Biomedical Literature (CBM) and Chinese science and ...
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Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus
... 10), cyclosporine A (CsA; n = 6), tacrolimus (FK506; n = 1), leflunomide (LEF; n = 2), myco- phenolate mofetil (MMF; n = 8), methotrexate (MTX; n = 8)), and 59 were receiving an antimalarial drug (chloro- ...
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Efficacy and safety of cyclosporine a for patients with steroid-resistant nephrotic syndrome: a meta-analysis
... of CsA vs. CYC and CsA vs. TAC. CsA treatment results in a higher TR when compared to ...The CsA group also had a higher CR than the CYC group, although this difference was not ...that ...
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Cyclophilins: The Structure and Functions of an Important Peptidyl-prolyl Isomerase
... Cyclophilins can act as foldases or chaperones. They possess peptidyl-prolyl isomerases (PPIase) activity, which is inhibited by cyclosporine A (CsA). Their PPIase activity makes them be able to accelerate ...
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Metastatic Merkel cell carcinoma and myasthenia gravis: contraindication for therapy with immune checkpoint inhibitors?
... Case presentation: A 61-year-old woman with a history of MG since 2005 was treated with azathioprine and pyridostigmine after thymectomy. In March 2016, she was diagnosed with MCC. Six months later the tumor had ...
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Mesenchymal stem cells overexpressing IL-35: a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance
... In 2002, Bartholomew et al. [36] observed that MSCs could suppress lymphocyte proliferation in vitro and in vivo. Administration of MSCs led to prolonged skin graft survival in baboons when compared to control animals ...
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A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations
... Results: Distribution studies showed that 64.76% ± 8.35% of the formulation coded “F8+SLN” remained on the buccal mucosa 6 hours after application. For the second part of the in vivo experiments, 36 rabbits were ...
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Mesenchymal stem cell-based therapy in kidney transplantation
... and cyclosporine-resistant GVHD with ...low-dose cyclosporine A (CsA) reversed the protective influence of CsA and accelerated allograft re- jection ...low-dose CsA, MSCs could not ...
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
... Finally, cyclosporine A (CsA) was used as an illustrative case to support applicability of zebrafish embryo in hepatotoxicity testing by comparing CsA-induced gene expression between [r] ...
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Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
... inhibitor Cyclosporine A (CsA) accumulated more of the P-gp substrate Rhoda- mine 123 (R123) than non-CsA-treated cells, indicating that P-gp is active in these ...with CsA inhibition (Fig. ...
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Mycophenolic Acid Absorption Profiles in Patients with Kidney or Combined Pancreas Kidney Transplantation
... in cyclosporine A (CsA) or tacrolimus (Tac)-based immunosuppression for renal transplant patients, but also after liver, heart, and simultaneous pancreas-kidney transplantation ...of cyclosporine and ...
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Invasive mycoses in patients with connective tissue disease from Southern China: clinical features and associated factors
... (1/197) in SSc, and 0.4% (3/728) in PM/DM. Proven in- fection accounted for 18.8% (6/32) of the cases, and probable infection for 81.3% (26/32). All patients were of Chinese Han ethnicity. Of the 32 patients enrolled, ...
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Drug-induced gingival hyperplasia: a retrospective study using spontaneous reporting system databases
... Drug-induced gingival hyperplasia (DIGH) is a peri- odontal side effects of certain drugs, causing swelling, bleeding, and problems with chewing, aesthetics, and pronunciation. In more severe cases, it can cause high ...
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Association of IL1 beta gene polymorphism and allograft functions in renal transplant recipients :a case control study from Kashmir Valley
... Patients with other reasons (other than immunological cause) for transplant rejection or failure like Technical Problems, Graft failure due to any drug(like NSAIDS, herbal medications and other nephrotoxic drugs),or dye ...
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Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice
... following CsA challenge, and their findings point to a critical role of YB-1 in the resolution of inflammatory processes which may largely be due to calcineurin mediated dephosphor- ...
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