CTL epitope
Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
... lymphocyte epitope was truncated at the C34 valine anchor residue for binding to K d , the residual CD4 + T cell epitope, B24–C32/33, significantly inhibited diabetes development after a single intranasal ...
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Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection
... single CTL epitope in Gag, and the fact that this epitope does not escape in control macaques until well into the chronic phase of infection, suggests that CTL against the Gag CM9 ...
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Engineering of papaya mosaic virus (PapMV) nanoparticles with a CTL epitope derived from influenza NP
... H-2Kd epitope specific for Balb/C mice derived from influenza virus to search for the optimal position for fusion of this epitope to the vaccine ...The CTL epitope was flanked by 5 native ...
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Prediction of CTL epitope, in silico modeling and functional analysis of cytolethal distending toxin (CDT) protein of Campylobacter jejuni
... The epitope based vaccines encourage an immune response by presenting immuno- genic peptides unite to major histocompatibility complex to TCR ...predict epitope and ligand binding sites in ...of CTL ...
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Portable flanking sequences modulate CTL epitope processing
... immunodominant epitope and the progressive loss of the subdominant ...no epitope (white bars) were identi- fied by mass ...HLA-A3 epitope, RY10 (RLRPGGK- KKY), codominant with RK9 in acute infection ...
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Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity.
... In contrast, the four anti-NP clones shown here mirrored the Primary anti-LCMV ARM splenic CTL and various CTL clones were incubated with H-2d targets which were either uninfected, coate[r] ...
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Use of Molecular Beacons for Rapid, Real Time, Quantitative Monitoring of Cytotoxic T Lymphocyte Epitope Mutations in Simian Immunodeficiency Virus
... virus CTL epitope ...emerging CTL epitope mutations rely on the labor- intensive and time-consuming techniques of virus population or clonal ...large-scale CTL epitope ...
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Immunogenicity of Recombinant Classic Swine Fever Virus CD8+ T Lymphocyte Epitope and Porcine Parvovirus VP2 Antigen Coexpressed by Lactobacillus casei in Swine via Oral Vaccination
... CSFV-specific CTL epitope 290 gene, synthesized by PCR, were successively cloned as SalI/XhoI and BamHI/SalI fragments into pET-20b( ⫹ ), generating pET-VP2 and pET-E290-VP2, respec- ...
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Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6 Envelope Protein
... corresponding epitope from HIV-1 ...study CTL responses to the HIV-1 envelope protein expressed in MVA ...useful epitope to monitor the responses and, in particular, to determine whether the sequence ...
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Novel Immunodominant Peptide Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-Lymphocyte Epitope Stabilized by Intrachain Hydrogen Bonds from Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein
... presented CTL epitopes in the context of any given HLA allele of ...HLA-A2-restricted CTL epitopes have been reported for SARS-CoV-derived proteins (16, 22, 31, 43, 46, 47, ...specific CTL ...
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Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine Containing Multiple HLA A2 HIV CD8+ Cytotoxic T-Cell Epitopes
... the CTL epitope regions, which might adversely affect the immune response (7, 17, 20), can also be ...an epitope-based approach would be of advantage only if multiple CTL epitopes covering a ...
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Evolutionary dynamics of genetic variation in Epstein-Barr virus isolates of diverse geographical origins: evidence for immune pressure-independent genetic drift.
... the CTL response has played a role in the emergence of variant viruses requires either the direct demonstration of fitness differences between variants or an indirect approach consisting of detecting selec- tion ...
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Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope despite Multiple Variations in the Epitope Flanking Sequences
... infection, CTL specific for HIV-1-derived, human lymphocyte antigen (HLA) class I-restricted epitopes are also believed to be an important part of the host response against this virus ...HIV-1-specific CTL ...
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Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.
... culture CTL were assayed for reactivity against the T-antigen CTL epitopes in- dividually by using target cells (B6/K-1,4,5) pulsed with the corresponding synthetic ...reductase CTL epitope ...
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Use of a novel enhanced DNA vaccine vector for preclinical virus vaccine investigation
... The porcine circovirus type 1 capsid gene promoter improves antigen expression and immunogenicity in a HIV-1 plasmid vaccine.. DNA multi-CTL epitope vaccines for HIV and Plasmodi[r] ...
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Immunization with a Single Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Recognition Epitope of Herpes Simplex Virus Type 2 Confers Protective Immunity
... I-restricted CTL recogni- tion epitopes HSV gB498-505 (SSIEFARL) (8, 24) and SV40 Tag404-411 (VVYDFLKC) (50) as peptides fused to the adenovirus type 5 E3/19k endo- plasmic reticulum insertion sequence (ES), ...
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Discovery of novel targets for multi epitope vaccines: Screening of HIV 1 genomes using association rule mining
... utilizing CTL epitopes identified as participants in association rules (such as those depicted on Figure ...one epitope from the rule is present in the viral genome, the other epitopes from the rule will ...
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Alphavirus-Specific Cytotoxic T Lymphocytes Recognize a Cross-Reactive Epitope from the Capsid Protein and Can Eliminate Virus from Persistently Infected Macrophages
... about CTL activity during the primary viremia, the clear demonstration that QYSGGRFTI- specific CTL were capable of completely clearing RR virus from persistently and productively infected macrophage cul- ...
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Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax.
... by CTL, seem to have a severely reduced functional ...of CTL recognition of the mutant proteins. Certain variant peptide epitope sequences, which themselves are not recognized by T cells, have been ...
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Local replication of simian immunodeficiency virus in the breast milk compartment of chronically infected, lactating rhesus monkeys
... whether CTL escape of two Mamu-A*01- restricted immunodominant epitopes Tat TL8 and Gag p11C occurred at a different rate in milk and blood virus ...TL8 epitope was amplified by SGA with primers described ...
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