Cultured cortical neurons
Danggui Buxue Tang, an ancient Chinese herbal decoction, protects β amyloid induced cell death in cultured cortical neurons
... primary cultured neurons were analyzed. Application of Aβ in cultured cortical neurons provoked cell death obvi- ously in a dose-dependent manner ...
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Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons
... in cultured cortical neu- rons, and we found that the knockdown of ATBF1 by ATBF1 siRNA transfection significantly reduced the extent of cell death and apoptosis induced by A b 1-42, etoposide, ...in ...
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-induced neuronal apoptosis and synaptotoxicity in primary cultured cortical neurons possibly via modulating both PI3K/AKT and ERK signaling pathways
... in cortical neurons. Material and method: The primary cortical neurons treated with Aβ 1-42 were used as the AD cell ...of cortical neurons was analyzed by Hoechst 33342 ...
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Silver nanoparticles (AgNPs) cause degeneration of cytoskeleton and disrupt synaptic machinery of cultured cortical neurons
... we cultured cortical neurons for 10 days and allowed for the establishment of a network and matur- ation of synaptic ...control neurons displayed extensive dendritic arborization and mature ...
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Progesterone with Vitamin D Affords Better Neuroprotection against Excitotoxicity in Cultured Cortical Neurons than Progesterone Alone
... In addition to MAPK, on which com- bined PROG and VDH treatment showed a synergistic effect, other mechanisms of VDH could compensate for PROG’s lesser or missing effects and would be very interesting to investigate. For ...
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Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction
... The study protocol was reviewed and approved by the institutional review board (IRB) of the Changzhi Medical College, People’s Republic of China (IRB number 2015- 021453) in accordance with the guidance for the care and ...
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EFFECTS OF RHYNCHOPHYLLINE ON RAT CORTICAL NEURONS STRESSED BY METHAMPHETAMINE
... on cortical neurons in rats and to study the protective effects of Rhynchophylline (Rhy) on MA treated ...primary cultured cortical neurons. The viability of neurons treated MA ...
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Original Article Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults
... wild-type cultured cortical neurons, not only the amplitude of ASICs current and the calcium transients induced by acidosis were both increased after OGD-Rep, but also the total protein levels of ...
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Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury
... Most cultured cortical neurons had series resistance around 7-8 MΩ (range, 4-13 ...of cortical neurons were considered as unhealthy and discarded due to rest- ing membrane potentials ...
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TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis
... in cultured cortical neurons follow- ing NRG1 treatment, which was blocked by AG1478, the ErbB4 kinase inhibitor (Figure ...in neurons treated with BDNF neutralizing antibody as compared to ...
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Amyloid beta-peptide induced oxidative stress and mitochondrial respiratory chain damage: A mechanism for cell death in Alzheimer's disease
... primary neurons and the cell lines PC 12 and ...primary neurons with respect to energy metabolism. Primary neurons are very dependent on mitochondrial respiration to maintain energy production, ...
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TRPM2 in the Central Nervous System: Physiological Role and Critical Regulatory Pathways
... TRPM2 is a non-selective cation channel which is permeable to calcium. Although expression is highest in the brain, the physiological role for TRPM2 in neurons is unknown. Furthermore, our understanding of the ...
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Increased expression of retinoic acid-induced gene 1 in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression
... At first, we assessed if there was a significant difference for the confounding variables between the various diagnostic groups either by analysis of variance (ANOVA) or logistic regression. As a second step, to ...
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β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network
... seeding cortical neurons in μFD devices comprising two cham- bers connected through asymmetrical micro-channels (2C-μFD ...chamber, cortical neurons projected their axons from the ...
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Rabies virus infection of cultured rat sensory neurons.
... Taking advantage of the nerve growth factor-induced differentiation of neuronal cells, we have studied the interaction of rat sensory neurons with rabies virus CVS strain, using a compar[r] ...
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Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons
... the cortical plate express at least three essential elements of the reelin signaling cascade: the two reelin receptors Vldlr (very low density lipoprotein receptor) and ApoER2 (apolipoprotein E receptor 2; also ...
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Hedgehog signaling is involved in development of the neocortex
... telencephalon, functions of Shh in this region are unclear, and detailed characterization of Shh mRNA transcripts in situ has not been demonstrated. To clarify the roles of Shh signaling in dorsal pallium (neocortex ...
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Index Catalog // Carolina Digital Repository
... mechanism of learning in the human brain (reviewed (Muller-Dahlhaus et al. 2010)). For example, “STDP-like” pairing of electrical wrist-nerve stimulation (NS) and transcranial magnetic stimulation (TMS) over motor cortex ...
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Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes
... The modified indirect MTT method was performed to in- vestigate cell viability under UCB stimulation, which could eliminate the interference of bilirubin deposits [29]. Briefly, astrocytes were cultured on 96-well ...
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Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity
... IL-6 gene expression in cultured astrocytes is enhanced by NECA [36,38], similar to our present findings with LIF. Since NF-κB is a key transcription factor that regu- lates IL-6 gene expression [50,51], we ...
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