CXCL12/CXCR4
The CXCL12/CXCR4 signaling axis retains neutrophils at inflammatory sites in zebrafish
... the CXCR4 receptor at three main interaction residues located around the main ligand binding pocket of CXCR4 in transmembrane domains IV, VI and ...of CXCL12 and prevents subsequent downstream ...
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The Role of CXCL12-CXCR4 Signaling Pathway in Pancreatic Development
... The CXCL12-CXCR4 signaling pathway has key roles in the vascular ...formation. Cxcl12 or Cxcr4 mu- tant embryos die before ...that CXCL12 and CXCR4 are expressed in the mouse ...
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Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
... receptor CXCR4 is a representative target gene ...of CXCL12 and CXCR4 in PCa specimens accompanied by ...expressed CXCL12, but the majority of cancer cells surrounding or infiltrating in ...
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Emerging targets in cancer management: role of the CXCL12/CXCR4 axis
... the CXCR4-targeting anticancer therapy is a potential side effect on the stem cell compartment in normal ...of CXCR4 inhibition and conventional ...between CXCR4 and tumor initiating cells in cancer ...
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CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord
... for CXCL12. CXCL12/CXCR4 chemokine signaling plays a critical role in modulating various nervous system developmental processes and in regulating synaptic plasticity ...exogenous CXCL12 into ...
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CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR
... chemokine CXCL12 binds the two receptors CXCR4 and CXCR7 and transduces on the mTOR pathway in pancreatic cancer, gastric cancer, T cell leukemia cell and in human renal cancer cells [26- ...that ...
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Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9 A10 dopaminergic neurons
... Dopaminergic (DA) neurons, residing in the ventral midbrain (VM), are known to sequentially follow radial and tangential migration routes (Hanaway et al., 1971; Kawano et al., 1995), send long axonal processes and ...
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CXCR7 prevents excessive CXCL12 mediated downregulation of CXCR4 in migrating cortical interneurons
... The CXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal ...second CXCL12 receptor, CXCR7, is essential for the proper migration of interneuron ...
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Original Article CXCL12 induces migration of Schwann cells via p38 MAPK and autocrine of CXCL12 by the CXCR4 receptor
... that CXCL12 is a powerful che- mokine that can promote directional migration of various stem cells through interaction with its receptor CXCR4 and CXCR7 ...ermore, CXCL12 can promote regeneration of ...
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Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease
... of CXCL12 mRNA were found in RA synoviocytes [18, 19] and elevated CXCR4 expression by synovial memory T cells was reported [19, 20] suggesting that CXCL12/CXCR4 play a role in the recruitment ...
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Original Article Association between CXCL12 and CXCR4 polymorphisms and inflammatory bowel disease risk in a Guangxi Zhuang population
... of CXCL12/CXCR4 and Guangxi Zhuang IBD pa- tients in China using PCR-RFLP, we found that there was no significant association between mutation of the CXCL12 gene (rs1801157) and IBD in Guangxi Zhuang ...
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Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis
... in CXCR4 signalling in cancer has not been addressed so ...of CXCL12/CXCR4 axis enhances migration and invasion of cancer cells, thus leading to metastasis [57, 58] and may regulate antitu- mor ...
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Osteotropism of neuroendocrine tumors: role of the CXCL12/ CXCR4 pathway in promoting EMT in vitro.
... of CXCL12 were silenced in cells lacking the expression of CXCR4, thus supporting its crucial role in mediating the effects of ...Although CXCR4 is a membrane receptor, its intracellular segregation ...
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Original Article Prognostic significance of CXCL12, CXCR4, and CXCR7 in patients with breast cancer
... a CXCL12 gradient that would lead to the formation of a guidance cue for CXCR4- positive cells ...of CXCR4/CXCR7 heterodimers enhancing CXCL12 signaling in embryonic cells was observed, ...
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The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease
... demonstrate CXCL12-induced proliferation of EWS cell lines expressing substantial levels of CXCR4, which could be inhibited by CXCR4-antagonist ...(stroma-derived CXCL12) rather than autocrine ...
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The Role of G Protein-coupled Receptor Kinases in Cancer
... G Protein Coupled Receptor Kinase 3 (GRK3) Negatively Regulates CXCL12/CXCR4 Signaling and Tumor Migration in Breast Cancer. Journal of Allergy and Clinical Immunology[r] ...
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Post-CNS-inflammation expression of CXCL12 promotes the endogenous myelin/neuronal repair capacity following spontaneous recovery from multiple sclerosis-like disease
... of CXCL12 in adult CNS following MS-like inflam- matory ...the CXCL12/CXCR4 axis appears to be involved in promoting the endogen- ous myelin and neuronal repair capacity, particularly in mice ...
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PubMedCentral-PMC4822790.pdf
... high CXCR4 expression, increased metastatic potential, and poor patient prognosis [47, ...to CXCL12/CXCR4 migration in breast cancer and specific molecular ...in CXCR4 expression. In our ...
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Corruption of Human Follicular B-Lymphocyte Trafficking by a B-Cell Superantigen
... the CXCL12/ CXCR4 pair is important for the reten- tion of precursor B cells, and also for that of long-lived plasma cells in particular ...niches. CXCL12- or CXCR4-deficient mice have ...
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Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma
... for CXCL12. The CXCL12/CXCR4 axis is critical to the retention of B-cell precursors in bone marrow (BM), homing of B lymphocytes to lymph nodes, and infiltration of T-cells and other immune cells ...
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