CXCL12-CXCR4 axis
<p>CXCL12/CXCR4 Axis-Targeted Dual-Functional Nano-Drug Delivery System Against Ovarian Cancer</p>
... the CXCR4 receptor-coupled G protein, then activates phosphatidyl alcohol-3 kinase (PI3), mito- gen-bound protease (MAPK), and the transcription factor ...the CXCL12/CXCR4 axis has been shown ...
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Emerging targets in cancer management: role of the CXCL12/CXCR4 axis
... chemokine CXCL12 (SDF-1) and its cell surface receptor CXCR4 were first identified as regulators of lymphocyte trafficking to the bone ...the CXCL12/CXCR4 axis was proposed to regulate ...
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Noninvasive application of mesenchymal stem cell spheres derived from hESC accelerates wound healing in a CXCL12-CXCR4 axis-dependent manner
... human CXCL12 and upregulated mouse genes, we found that the expression of murine Cxcr4, Tnni1, Rhob, Pgf, Krt6a, and Jag1, which are all CXCL12 signaling effectors [33], was significantly correlated ...
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Disrupting the CXCL12/CXCR4 axis disturbs the characteristics of glioblastoma stem-like cells of rat RG2 glioblastoma
... of CXCR4 in regulating the characteristics of CSCs, we tested sphere formation by using an ultralow plate sys- tem and a modified plate-well designed to test self- renewal properties by preventing cell attachment ...
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Innate Immunity Derived Factors as External Modulators of the CXCL12 - CXCR4 Axis and Their Role in Stem Cell Homing and Mobilization
... tein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell ...niches. CXCL12 has also been identified as a ...
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<p>Significance of CXCL12/CXCR4 Ligand/Receptor Axis in Various Aspects of Acute Myeloid Leukemia</p>
... that CXCL12/ CXCR4 axis plays remarkable parts in leukemic cell resis- tance to the signal transduction inhibitor as well as che- motherapy-induced ...the CXCL12/ CXCR4 interaction ...
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Post-CNS-inflammation expression of CXCL12 promotes the endogenous myelin/neuronal repair capacity following spontaneous recovery from multiple sclerosis-like disease
... of CXCL12 in adult CNS following MS-like inflam- matory ...the CXCL12/CXCR4 axis appears to be involved in promoting the endogen- ous myelin and neuronal repair capacity, particularly in mice ...
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Original Article Prognostic significance of CXCL12, CXCR4, and CXCR7 in patients with breast cancer
... the CXCL12/CXCR4 axis has been shown to play a relevant role in experimental models of ...that CXCR4 is consistently expressed in human breast cancer cells, while its ligand CXCL12 is ...
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Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4
... for CXCR4, to demonstrate that CXCR4 is a mediator between Notch1 and the AKT/mTOR pathway, 100 ng/ml CXCL12 was used to stimulate CXCR4 after incubation for 30 min ...expected, CXCL12 ...
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Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
... the CXCL12/CXCR4 axis plays a pivotal role in the neurotropism of pancreatic cancer cells to local peripheral ...that CXCR4 elevation correlated with PNI in 78 pancreatic cancer ...the ...
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CXCR4/CXCL12 Axis in Non Small Cell Lung Cancer (NSCLC) Pathologic Roles and Therapeutic Potential
... of CXCR4 in NSCLC spread and disease outcome comes from the two additional ...produced CXCL12 and that high level of CXCL12 in the pleural fluid were associ- ated with seeding of the pleural space ...
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Osteotropism of neuroendocrine tumors: role of the CXCL12/ CXCR4 pathway in promoting EMT in vitro.
... between CXCL12 and CXCR4 can be hypothesized also for NETs, since evidence in other cancers suggests that persistent ligand stimulation causes CXCR4 degradation, as well as epigenetic regulation of ...
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rcmb.2012-0198oc.pdf
... the CXCR4 antagonist AMD3100 to block fibrocyte ...of CXCL12 (or stromal cell-derived factor 1 [SDF-1]) that led to increased fibrocyte ...decreasing CXCL12 expression and subsequent fibrocyte re- ...
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Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma
... for CXCL12. The CXCL12/CXCR4 axis is critical to the retention of B-cell precursors in bone marrow (BM), homing of B lymphocytes to lymph nodes, and infiltration of T-cells and other immune ...
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Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis
... in CXCR4 signalling in cancer has not been addressed so ...of CXCL12/CXCR4 axis enhances migration and invasion of cancer cells, thus leading to metastasis [57, 58] and may regulate antitu- ...
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Original Article Association between CXCL12 and CXCR4 polymorphisms and inflammatory bowel disease risk in a Guangxi Zhuang population
... of CXCL12/CXCR4 and Guangxi Zhuang IBD pa- tients in China using PCR-RFLP, we found that there was no significant association between mutation of the CXCL12 gene (rs1801157) and IBD in Guangxi Zhuang ...
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Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease
... ubiquitous CXCL12 (initially called SDF1-α) which signals via the chemokine receptors CXCR4 and ...decade CXCL12 was recognized to participate not only in embryonic development and homeostatic ...
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CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter
... The CXCR4 chemokine receptor belongs to a large superfamily of G-protein-coupled receptors and is known to be upregulated in a wide variety of cancers, including breast cancer and ...overexpressing CXCR4 by ...
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Corruption of Human Follicular B-Lymphocyte Trafficking by a B-Cell Superantigen
... the CXCR4 downmodulation in- duced by CXCL12 or by polyclonal anti- IgM Ab was maximal after 2 h or 16 h, ...of CXCR4 downmod- ulation after culturing B cells for 2 h in medium alone or in the ...
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Original Article CXCL12 induces migration of Schwann cells via p38 MAPK and autocrine of CXCL12 by the CXCR4 receptor
... of CXCL12 after CXCL12 acts on SCs, thus, forming a positive feedback ...If CXCL12 is slowly released at the lesion, only a small amount of CXCL12 can play a pivotal ...that CXCL12 ...
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