Cyclin D/Cdk4
Cyclin D Does Not Provide Essential Cdk4-Independent Functions in Drosophila
... Drosophila Cyclin D containing the primers df (5⬘-GTA CAG GAT CTT TAA GTG and Cdk4 do not provide independent functions that CAG C-3⬘), dr (5⬘-ATC TCT TGC TCA CTG CGA TCA G-3⬘), are vitally important ...
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Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth
... and cyclin partners is mediated by the C helix of the CDK and the α5 helix of the cyclin partner [30, ...between CDK4 and cyclin D could therefore constitute an attractive alternative ...
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Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... inhibits cyclin D-Cdk4 activity via c-Jun N-terminal kinases (JNKs) ...[36–38]. Cdk4 activation is required for phosphorylation of the T172 of Cdk4 [39], a residue that is not present ...
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The role of cyclin D2 and p21/waf1 in human T cell leukemia virus type 1 infected cells
... the cyclin Ds and p21/waf1 are often seen deregulated in viral ...instance, cyclin D2 is upregulated in Epstein-Barr virus (EBV) infected cells [47,48] and cyclin D1 is upregulated in Sim- ian virus ...
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Treating cancer with selective CDK4/6 inhibitors.
... of cyclin D/CDK4 is p16, which contributes to G1 arrest in two ...functional, CDK4 requires cytoplasmic, post-translational folding in a complex involving HSP90, an interaction disrupted by ...
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Original Article Expression of cell-cycle regulators is associated with invasive behavior and poor prognosis in prolactinomas
... detectable cyclin E1, and express p27Kip1 ...that cyclin D1 and cyclin E1 are almost undetect- able in the normal pituitary, while p16 and p27 expression levels are relatively ...B, D and E ...
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PubMedCentral-PMC5757913.pdf
... Since D-type cyclins are expressed in most cell types, including fibroblasts, epithelial cells, and various lineage progenitor cells ...for cyclin D/CDK4/6 as a master regulator of G1 timing ...
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Functional analysis of p16INK4a and p21CIP1 in replicative senescence
... of cyclin D- CDK4 complexes but questioned the relevance of these complexes in the switch from proliferation to growth ...of cyclin D-CDK ...in cyclin Dl levels and a reduction ...
239
CDK4 activity in mouse embryos expressing a single D type cyclin
... of cyclin D–CDK4 complexes and its phosphorylation status re- flects CDK ...only cyclin D3 or only cyclin ...only cyclin D1 ...by cyclin D-dependent kinases i.e. ...
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Novel germline CDK4 mutations in patients with head and neck cancer
... of CDK4 revealed two missense mutations, Ser52Thr and Glu67Gln on exon ...decreased cyclin binding of CDK4 by greater than 80% also decreased kinase activity ...of cyclin binding of the ...
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Cyclin dependent kinases
... between cyclin D and Cdk4 or Cdk6 phosphoryl- ate residues Ser807 and Ser811, priming Rb for further phosphorylation by these or other CDKs at other sites ...when Cdk4 and Cdk6 are absent, ...
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The cell cycle as a brake for β-cell regeneration from embryonic stem cells
... of D cyclins (D1, D2 and D3), which bind to and activate ...Cdk-4–cyclin D pathway on the cell cycle in β cells, but they fail to demonstrate why or how it is so tissue-specific ...of CDK4 ...
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To Cycle or Fight-CDK4/6 Inhibitors at the Crossroads of Anticancer Immunity.
... both CDK4/6 and D type cyclins in an oscillating manner as cells undergo repeated cycles of cell ...differentiate, Cyclin D remain low in the majority of T cells, with the exception of ...
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The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer
... inhibits CDK4 and CDK6, maintaining RB in its hypophosphorylated E2F- associated state, and thereby preventing G1-to-S phase progression (Figure 1) ...or Cyclin D1 overexpression ...
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Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma
... included cyclin dependent kinases (CDKs), members of the retinoblastoma protein family, DNA replication factors such as the cell division cycle proteins (CDCs), members of the CIP/KIP family, and the INK4 family ...
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Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... demonstrated that doxycycline withdrawal resulted in suppression of mir-155 expression and subsequent tumor shrinkage [89]. In this mouse model, anti-miR- 155 treatment resulted in decreased tumor burden, indi- cating ...
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Original Article Catechin protects rat cardiomyocytes from hypoxia-induced injury by regulating microRNA-92a
... First, we assessed the effects of hypoxia on H9c2 cell viability, proliferation, and apoptosis by using CCK-8 assay, western blotting, and Annexin V-FITC/PI apoptosis detection kit, respectively. Figure 2A presented that ...
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p63 amodulates c-Myc activity via direct interaction and regulation of MM1 protein stability
... of CDK4 and Cyclin D1, and impaired cell cycle progression, both of which are effectively reversed by simultaneous knockdown of ...and CDK4 is concomitantly up-regulated in B-cell acute lymphoblastic ...
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Interplay of Id and INK4 proteins in cellular senescence
... Gi cyclin- CDK ...of cyclin E- and A-dependent CDK2, they can act as positive regulators of cyclin D-dependent kinases (LaBaer et ...inhibits cyclin-CDK kinase activity is not clear, ...
207
Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
... aberrant cyclin D1/CDK4 activity in MCL is critical for NOXA protein induction and thereby directly contributes to cell death triggered by proteasome ...myeloma, cyclin D1 overexpression is also ...
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