cyclin D3
Cyclin D3 predicts disease-free survival in breast cancer
... As we known, cell migration requires dynamic remod- eling of the actomyosin network [26]. It is reported that decreased beta-actin expression in normal corneal stroma clearly disrupts the cytoskeletal structure and ...
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Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3.
... to cyclin D3 specifically formed complexes with ICP0 contained in HSV-1-infected cell ...of cyclin D3, the gene was inserted into the viral genome and overexpressed in infected ...
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MicroRNA 503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma
... Our study determined that downregulation of miR-503 occurred frequently in HCC tissues and cell lines. miR- 503 downregulation was correlated with more aggressive disease as well as shorter overall survival, and was an ...
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Interwoven Roles of Cyclin D3 and cdk4 Recruited by ICP0 and ICP4 in the Expression of Herpes Simplex Virus Genes
... The infected cell protein 0 (ICP0), an ␣ protein encoded by herpes simplex virus 1 (HSV-1), interacts with many diverse cellular proteins and performs multiple functions (19). The major interactions and functions ...
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Role of Cyclin D3 in the Biology of Herpes Simplex Virus 1 ICP0
... stabilize cyclin D3 also resulted in the loss of the capacity of ICP0 to stabilize cyclin D1 even though it did not interact with this ...with cyclin- dependent kinases to form an active ...
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Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells
... overexpress cyclin D3) were grown in Ham’s F12 medium supplemented with 5% calf serum in the presence of 6 hormones (thyrotropin, hydrocortisone, insulin, transferrin, somatostatin, and glycyl-histidyl- ...
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Prognostic significance of cyclin D3 expression in malignancy patients: a meta-analysis
... promoter, cyclin D3 can promote the abnormal growth and tumorigenesis of different kinds of tumors, such as diffuse large B cell lymphoma, which can serve as a promoter for regulating the progression of ...
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Investigation of the Cyclin D3-Cyclin D2 Negative Feedback Loop.
... and D3 – is induced by mitogens during G1, and their continued synthesis depends upon growth factor stimulation (Sherr ...cyclins, cyclin D3 is the least well ...that cyclin D1 accumulates ...
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The Role of CDK6 and Cyclin D3 in Keratinocyte Proliferation and Mouse Skin Carcinogenesis.
... Figure 13. Kinase activity of CDK4 and CDK2 from wild‐type (wt), K5D3, cyclin D1‐/‐ (D1‐/‐) and K5D3/D1‐/‐ epidermis. Fresh epidermal lysates were immunoprecipitated with specific antibodies against CDK4 and CDK2 ...
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GSK3β mediates muscle pathology in myotonic dystrophy
... plasmic cyclin D3 ...regulates cyclin D3, we thought that GSK3β might be misregulated in DM1 ...reduces cyclin D3, the cells with increased levels of GSK3β had reduced levels of ...
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Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down regulation of cyclins D3, E, and A
... since cyclin D3 plays a critical role in mammary tumorigenesis [85,86] but has not yet been spe- cifically targeted with ...that cyclin D3 preferentially promotes devel- opment of squamous ...
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Varicella-Zoster Virus Infection of Human Foreskin Fibroblast Cells Results in Atypical Cyclin Expression and Cyclin-Dependent Kinase Activity
... kinases. Cyclin-dependent kinases (CDKs) and cyclins displayed a highly unusual profile in VZV-infected confluent fibroblasts: total amounts of CDK1, CDK2, cyclin B1, cyclin D3, and ...
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Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II
... whether cyclin T1/CDK9 affects the replication of influenza A virus, we took the approach of RNA interference to knock down cyclin T1 ...of cyclin T1 with siRNA or short hairpin RNA (shRNA) did not ...
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Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer
... knockout cyclin E1 -/- E2 -/- mice die in utero due to impairments in endoreplication of the trophoblast giant cells (TSCs) that form the pla- centa, and perform a crucial role in placental attach- ment and ...
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Functional Characterization of a New Member of the Cdk9 Family in Aspergillus nidulans
... In this study we identified and characterized the Cdk PtkA in the filamentous ascomycete A. nidulans. Isolated by screening of the A. nidulans genome for sequences related to the Cdc2 homolog NimX, the protein sequence ...
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Comparison of effects of 1 alpha hydroxy vitamin D3 and 1,25 dihydroxy vitamin D3 in man
... patients were studied a second time after treatment for 2-5 mo. Doses varied from 0.14 to 5.4 mug/day to establish dose-response relationships. Urinary calcium was monitored in normal subjects, nine of whom received a ...
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Roles of Cyclin A and Cyclin B in Drosophila Female Meiosis
... the Cyclin A mRNA polyA tail is dramatically reduced, but the mechanism by which PNG facilitates Cyclin A mRNA polyadenylation is ...of Cyclin A after the metaphase I arrest is released (Vardy et ...
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Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation.
... the cyclin A gene promoter by E7. To test whether activation of the cyclin A promoter ac- counts for the observed increase of cyclin A mRNA in E7- expressing cells, we asked whether overexpression of ...
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Mills_unc_0153D_17509.pdf
... between Cyclin F and Sirt5, and suggests that it occurs in the cytoplasm of cells (Figure ...shows Cyclin F is excluded from the mitochondria while Sirt5 is found in both the mitochondria and cytoplasm ...
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Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1.
... of cyclin D1 that are achieved by introduction of a CMV-based expression ...of cyclin D1 in the XH-D1 overexpresser cell lines may not be sufficient to inactivate the amount of PCNA required to prevent DNA ...
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