cyclin-dependent
Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... 1997. Cyclin kinase inhibitors are increased during experimental membranous nephropathy: potential role in limiting glomerular epithelial cell proliferation in ...Human cyclin-dependent kinase 2 is ...
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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity
... encoding cyclin C is frequently lost, and cell lines derived from these tumors are dependent upon continued cyclin C depletion for growth ...of cyclin C depletion with cancer points to a pos- ...
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Cyclin-dependent kinases in C. elegans
... Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell- cycle machinery has ...
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Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... CCNE1 mainly coordinates with Cdk2 to facilitate G1/S progression of cell cycle [11]. In ovarian cancer cells, enforcing CCNE1 expression stimulates cell proliferation [6] and increases colony formation [12]. CCNE1 gene ...
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Cyclin-Dependent Kinase 1/Cyclin B1 Phosphorylates Varicella-Zoster Virus IE62 and Is Incorporated into Virions
... of cyclin-dependent kinase (CDK) ...of cyclin B1 from VZV-infected HFFs indicated that IE62 was included in the complex within infected ...and cyclin B1, and active CDK1 and cyclin B1 ...
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Retroviral Cyclin Controls Cyclin-Dependent Kinase 8-Mediated Transcription Elongation and Reinitiation
... retroviral cyclin (RV-cyclin), encoded by WDSV, has separable cyclin box and tran- scription activation ...to cyclin-dependent kinase 8 (CDK8) and enhances its kinase ...by ...
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Cyclin B2/cyclin dependent kinase1 dissociation precedes CDK1 Thr 161 dephosphorylation upon M phase promoting factor inactivation in Xenopus laevis cell free extract
... ABSTRACT Cyclin-dependent kinase 1 (CDK1) is the enzymatic subunit of M-phase Promoting Factor ...a cyclin B ...of cyclin B is thought to be a direct cause of MPF ...precedes cyclin B ...
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Inhibitors of cyclin-dependent kinases as cancer therapeutics.
... The CDKs are highly-validated targets for cancer therapeutics, because of their role in regulating critical cell cycle checkpoints and transcription. As kinases, CDKs are readily druggable and many CDK inhibitors have ...
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Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... of cyclin-dependent kinase 2 (cdk2) activity in serum-deprived VSMCs was associated with the formation of complexes between cdk2 and its inhibitory protein p27(KIP1) ...of cyclin A promoter ...of ...
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Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... Neuroblastoma are pediatric tumours that originate from the developing sympathetic nervous system. Current treatment regimens for high-risk tumours comprise a combination of high-dose cytostatics, radiation therapy, ...
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Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells
... kilodaltons. Cyclin D2 protein was seen at higher levels in HTLV-1-infected cells, as evident in lanes 2 and ...other cyclin D2 monoclonal antibodies, DCS-3 and DCS-5 (Neomarkers, Union City, ...
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Investigation of the role of cyclin dependent kinases in neuronal apoptosis
... inactivated in 70% of human tumours (Evan et al., 1995). Frameshift mutations in the pro-apoptotic bax gene have been detected in human colon carcinomas (Rampino et al., 1997). Relapse in childhood acute lymphoblastic ...
204
Cyclin dependent kinase regulation in haemopoietic cells
... level of compensation is set until it is no longer detected (Figure 4.10). Similarly, the PE-labelled cells should only be detected in the PE channel and observed as unstained in the FITC channel. In this application ...
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Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... 84 Having to measure multiple reactants can also increase the margin of error of the entire system. It also complicates determining the correct parameters required for solving the rate of reaction (Schnell and Mendoza, ...
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Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... cyclin D1 (Figure 5a) (the expression plasmid was kindly provided by Joshua D Liao, The Hormel Institute, Aus- tin, MN, USA). Compared with vector transfectant cells, the cyclin D1-overexpressing MCF-7 ...
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Cyclin dependent kinases
... Although the comparison of the yeast CDKs has pro- moted the convenient division between transcriptional and cell-cycle activities, the multiple interactions be- tween these two activities in higher eukaryotes makes it ...
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In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF 7 cell
... Figure 7 Strobilanthes crispus extract IC50 = 30 μg/mL upregulated the level of cyclin dependent kinase 4 and cyclin dependent kinase 2 fold change in treated MCF-7 cells as compared to [r] ...
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Geminivirus-Induced Gene Silencing of the Arabidopsis RETINOBLASTOMA-RELATED
... by cyclin-dependent kinases relieves E2F repression leading to activation of such as PCNA, CDC6, and RNR, which are necessary for DNA replication (Nevins, 1992; Ezhevsky et ...
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A clinico-genomic analysis of soft tissue sarcoma patients reveals CDKN2A deletion as a biomarker for poor prognosis
... CDK: cyclin-dependent kinase; CDKN2A: cyclin-dependent kinase inhibitor 2A; ctDNA: circulating tumor DNA; COG: Children’s Oncology Group; DDLPS: dedifferentiated liposarcoma; FNCLCC: ...
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Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... CiP, cyclin dependent kinase interacting protein; CDK, cyclin dependent kinase; CycD, cyclin D; DNA, deoxyribonucleic acid; eGFR, epidermal growth factor receptor; FOXO, forkhead box; ...
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