Cyclin-dependent kinase 5
Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity
... Cdk5: Cyclin-dependent kinase 5; COX-2: Cyclooxygenase 2; cPLA2: Cytosolic phospholipase A2; EDTA: Ethylenediaminetetraacetic acid; ERK: Extracellular signal-regulated kinase; GAPDH: ...
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Insights into the clinical value of cyclin dependent kinase 5 in glioma: a retrospective study
... protein kinase B; ANOVA: analysis of variance; CDK5: cyclin-dependent kinase 5; Dab: the disabled-1; DLC1: deleted in liver cancer 1; EGFR: epidermal growth factor receptor; FAK: focal ...
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An immunohistochemical study of cyclin dependent kinase 5 (CDK5) expression in non small cell lung cancer (NSCLC) and small cell lung cancer (SCLC): a possible prognostic biomarker
... Cyclin-dependent kinase 5 (CDK5) is vital in neural cell migration and differentiation and is activated by p35 or p39 [24], and CDK5 is considered to be essential in neuronal cells [25, ...of ...
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Liebl, Johanna (2008): Anti-angiogenic effects of Cyclin dependent kinase inhibitors: Novel function of Cyclin dependent kinase 5 in endothelial cell migration. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... In recent years, the (R)-stereoisomer of roscovitine has developed to one of the prior used and most frequently studied Cdk inhibitors. Thus, roscovitine has been evaluated for its effects on a wide variety of cultured ...
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Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
... Tau proteins are essential in assembly as well as mainten- ance of the structural integrity of microtubules [13-15]. However, Tau is abnormally hyper-phosphorylated and ag- gregated in AD. Aβ induces neuronal death and ...
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Molecular genetics of human primary microcephaly: an overview
... Homozygous mutations of cyclin-dependent kinase 5 regu- latory subunit-associated protein-2 (CDK5RAP2) have been recognised as the basis of MCPH3 [32]. This protein is composed of 38 exons ...
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Impacts of caring for a child with the CDKL5 disorder on parental wellbeing and family quality of life
... The CDKL5 disorder is a recently identified genetic disorder caused by mutations in the X-linked cyclin- dependent kinase-like 5 (CDKL5) gene [1]. These muta- tions were originally identified ...
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Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
... The present method was employed for studying the pharmacokinetics and biodistribution of the drug in mice. It is of great importance to use a single, suitable analytical method for both pre-clinical and clinical stud- ...
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Cyclin dependent kinase regulation in haemopoietic cells
... for 5 days are already undergoing the cellular differentiation ...E2F-1 dependent transcription is inhibited during differentiation of other cell types, CD34+ cells in culture for 5 days have not ...
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Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... Cells were trypsinised as described (section 2.2). Following trypsinisation, cells were centrifuged at 500g for minutes to form a pellet, which was then frozen at -80 o C. RNA extraction was performed using the PureLink ...
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Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... 100 cyclin A gene 5 9 flanking sequence upstream from a promoterless luciferase cDNA, and the expression vector pAC-CMV-p27, were provided by ...fectamine, 5 m g of reporter vector, 0–1 m g of ...
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Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... Measuring apoptosis and DNA synthesis. Apoptosis was measured by terminal deoxynucleotide transferase–mediated nick end–labeling (TUNEL) staining and staining with hematoxylin and eosin (H&E) and Hoechst 33342(Sigma ...
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Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... Mice with AMC711T neuroblastoma xenografts (~268 mm 3 ) were treated with a single i.p. injection of 5, 10 or 15 mg/kg AT7519 or saline. Blood samples were collected by cheek puncture (t = 1 min) or from the ...
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Emission spectra profiling of fluorescent proteins in living plant cells
... In this work, we generated series of entry clones (pENTR) of several FPs in order to create C- or N- terminal protein fusions with the MultiSite Gateway recombination technology. Then, we determined the emission spectra ...
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Transcriptional Downregulation of p27KIP1 through Regulation of E2F Function during LMP1-Mediated Transformation
... p27KIP1/cyclin-dependent kinase inhibitor 1B of Rattus norvegicus was previously described ...the 5⬘ end of the promoter were constructed using convenient restriction enzyme sites, p27-1066 ...
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Partial monosomy14q involving FOXG1 and NOVA1 in an infant with microcephaly, seizures and severe developmental delay
... the cyclin-dependent kinase-like 5 (CDKL5) gene located in Xp22 are found in most cases of early-onset seizure vari- ants, while the congenital variant of the syndrome has re- cently been ...
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Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts
... cyclin-dependent kinase inhibitor; TRICK2A: death receptor 5 or DR5 (also Apo2; TRAIL-R2; TRICK2; or KILLER); IAP3: inhibitor of apoptosis protein 3; HSIAH2: inhibitor of apoptosis protein 2; ...
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Retroviral Cyclin Controls Cyclin-Dependent Kinase 8-Mediated Transcription Elongation and Reinitiation
... Like cyclin C, RV-cyclin binds to and activates CDK8 kinase activity toward histone H3 and the CTD of RNA Pol II, but it does so to a greater extent ...protein kinase C alpha (PKC ␣ ) in NIH ...
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Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer
... CDK2: Cyclin- dependent kinase 2; ChIP: Chromatin immunoprecipitation; Cimp − : :Low CpG island methylator phenotype; Cimp+: High CpG island methylator phenotype; C-Myc: MYC proto-oncogene, BHLH ...
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Cyclin dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
... Traditional risk factors account for approximately half of an indi- vidual’s lifetime risk of cardiovascular disease (1, 2). The balance, therefore, is accounted for by a combination of unmeasured envi- ronmental ...
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