Cyclin-dependent kinases (Cdk)
Inhibitors of cyclin-dependent kinases as cancer therapeutics.
... As kinases, CDKs are readily druggable and many CDK inhibitors have been ...competitive CDK inhibitors, such as alvocidib for example, have generally failed to progress beyond early clinical ...poor ...
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Targeting the cyclin dependent kinases (CDK) 4/6 in estrogen receptor positive breast cancers
... family cyclin-dependent kinases (CDKs) ...discovered cyclin molecules in his studies of sea urchin egg division ...activating CDK proteins. This critical array of activators and ...
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Cyclin-dependent kinases in C. elegans
... Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell- cycle machinery has ...
12
The PHOA and PHOB Cyclin-Dependent Kinases Perform an Essential Function in Aspergillus nidulans
... Figure 1.—Similarity be- tween PHOA and PHOB with other cyclin-dependent kinases. The protein sequence align- ment of PHOA and PHOB (A. nidulans), Pho85 (S. cerevisiae), Pef1 (S. pombe), and CDK5 ...
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Cyclin dependent kinases
... between cyclin D and Cdk4 or Cdk6 phosphoryl- ate residues Ser807 and Ser811, priming Rb for further phosphorylation by these or other CDKs at other sites ...[26]. CDK-dependent inactivation of Rb ...
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Investigation of the role of cyclin dependent kinases in neuronal apoptosis
... pharmacological Cdk inhibitor selective for Cdk2, Cdc2, and Cdk5, was able to protect against NGF withdrawal-induced ...a Cdk inhibitor by conq)eting with ATP for binding to active Cdk/cyclin ...
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Requirement for Cellular Cyclin-Dependent Kinases in Herpes Simplex Virus Replication and Transcription
... inhibit cdk activity (38, 57) and cell cycle progression ...inhibit cdk activity in vitro (38, 57), we postulate that the inhibition of HSV replication by these drugs occurs through effects on cellular ...
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A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases
... these kinases have long been considered ideal targets for anti- cancer ...many Cdk inhibitors have been developed, some of which have progressed to clinical ...petitive Cdk inhibitors, especially ...
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Synthesis of ring constrained thiazolylpyrimidines: inhibitors of cyclin dependent kinases
... with CDK inhibitor ...isolated CDK enzymes ...multiple CDK inhibitory block by model compound 9g. Further evidence of CDK inhibition came from experiments with A549 cells whereby treatment ...
185
A novel role for the cyclin dependent kinase inhibitor p27Kip1 in angiotensin II–stimulated vascular smooth muscle cell hypertrophy
... termed cyclin-dependent kinases (Cdk’s), and their regu- latory subunits, the cyclins (6, ...D3), cyclin E, and cyclin A play an impor- tant role ...progression; cyclin E/Cdk2 or ...
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Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia
... cyclins, cyclin-dependent kinases (CDKs) [41], and CDK inhibitors (CKIs) [42], we also ex- amined the expression of these genes and observed that the mRNA expressions of p18, p21, p27, and p57 ...
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Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation
... Cyclin-dependent kinases (CDKs) play a key role in the regulation of cell cycle progression, and eventually cell division or cell proliferation ...and cyclin-dependent kinases ...
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Evidence for CDK-Dependent and CDK-Independent Functions of the Murine Gammaherpesvirus 68 v-Cyclin
... cellular cyclin-dependent kinases (CDKs) and is required for efficient reactivation from ...of CDK binding and ...in CDK binding as well as virus in which the entire v-cyclin ...
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Inflammasome inhibitors: promising therapeutic approaches against cancer
... and cyclin-dependent kinases [114], and activation of the p53 protein [114], leading to reductions in cancer cell proliferation, invasion, and ...
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OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases
... Additional file 1: Figure S1. OCT4 increased proliferation capacity and differentiation potential in hHFMSCs. Cell proliferation curve (a) and Clone formation assay (b) of hHFMSCs-P5 and hHFMSCs-P15, and the enlarged ...
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Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice
... element; CDK: Cyclin-dependent kinase; CYP2E1: Cytochrome P450 2E1; dUTP: Nick-end labeling; ERK: Extracellular signal-regulated kinase; FF: Fast food; FF-S: Fast food diet mice followed by saline ...
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The effect of cyclic adenosine monophosphate (camp) modulators on the activity of selected antimalarial drugs
... the ste6 gene of saccharomyces cerevisiae with pfmdr1 gene of Plasmodium falciparum. and Geyer, J.A. Cyclin-dependent protein kinases as therapeutic drug targets for antimalarial drug de[r] ...
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MCPractice-Cells.pdf
... catalysis, catalytic—acceleration of chemical reaction by lowering activation energy CDK—cyclin-dependent kinase cell—basic unit of living organisms cell cycle—stages a cell passes throu[r] ...
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The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma
... epoxide; CDK: cyclin-dependent kinase; CHFR: Checkpoint with FHA and ring finger; CRC: colorectal cancer; DACH1: Dachshund homologue 1; DNMT3A: DNA (cytosine-5-)-methyltransferase 3 alpha; EAC: ...
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Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure
... of cyclin-dependent kinase (Cdk) which controls the elongation phase of transcrip- tion by RNA polymerase II ...[19]. Cdk is a cell-cycle check point regulator, and one study showed Cdk9 may ...
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