Cyclin-Dependent Kinases (CDKs)
Cyclin-dependent kinases in C. elegans
... Abstract Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell- cycle ...
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Inhibitors of cyclin-dependent kinases as cancer therapeutics.
... As kinases, CDKs are readily druggable and many CDK inhibitors have been ...of cyclin dependent kinases (CDK) 2, 5 and 9 CYC065 derived from seleciclib – continue to be ...
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The inhibitors of cyclin-dependent kinases and GSK-3β enhance osteoclastogenesis
... (cyclin-dependent kinases/glycogen synthase kinase 3 β ) inhibitor, ken- paullone, and two Cdks inhibitors, olomoucine and roscovitine, all of which signi ficantly enhance os- teoclastogenesis of ...
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Novel Roles of Cyclin-Dependent Kinases 4/6 in Mouse Keratinocytes.
... of cyclin-dependent kinases (CDKs) mediates cell cycle defects, acquiring key features of cancer cells such as unscheduled proliferation, genomic instability (GIN) and chromosome instability ...
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Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines
... by cyclin-dependent kinases (CDKs) which require association with cyclins and phosphoryl- ation to be catalytically active ...of kinases [16] and limited toxicity and side effects [17, 18] ...
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Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.
... of cyclin-dependent kinases such as cdk4, cdk2, and cdc2 are all capable of phosphor- ylating E1A in ...these kinases in vitro are similar to the E1A sites phosphorylated in ...
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Inhibition of the Cyclin-Dependent Kinases at the Beginning of Human Cytomegalovirus Infection Specifically Alters the Levels and Localization of the RNA Polymerase II Carboxyl-Terminal Domain Kinases cdk9 and cdk7 at the Viral Transcriptosome
... cellular cyclin T1, Brd4, histone deacetylase 1 (HDAC1), and ...of cyclin-dependent kinases (cdks) in the establishment of this site, we used roscovitine, a specific inhibitor of cdk1, cdk2, ...
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CYCLIN DEPENDENT KINASES AND CELL CYCLE CONTROL
... P AUL M. N URSE Cancer Research UK, PO Box 123, 61 Lincoln’s Inn Fields, London WC2A 3PK, United Kingdom. The cell is the basic structural and functional unit of all living organisms, the smallest entity that exhibits ...
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A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases
... Inhibiting Cyclin-dependent Kinases * □ S Received for publication, February 28, 2013, and in revised form, July 23, 2013 Published, JBC Papers in Press, July 25, 2013, DOI ...
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Recent advances of cyclin-dependent kinases as potential therapeutic targets in HR+/HER2− metastatic breast cancer: a focus on ribociclib
... CDK4/6, cyclin-dependent kinases 4 and 6; DLTs, dose-limiting toxicities; ER+, estrogen receptor positive; H2N − , dihyrdidonitrogen negative; MRT, malignant rhabdoid tumors; PFS, progression-free ...
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Cyclin dependent kinases
... related kinases such as Cdk4 and Cdk6 mostly function by phosphorylating transcription regulators such as Rb or Smads [3,25], and the archetypal cell-cycle kinase Cdk1 also phosphorylates multiple transcription ...
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Synthesis of ring constrained thiazolylpyrimidines: inhibitors of cyclin dependent kinases
... P P Scheme 1.4. CDKs involved in promoting efficient mRNA elongation by phosphorylating the C- terminal domain (CTD) of RNA polymerase II (Pol II) (Figure taken from Ref 42). Increasingly it has become recognised that ...
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Requirement for Cellular Cyclin-Dependent Kinases in Herpes Simplex Virus Replication and Transcription
... inhibit cyclin-dependent kinase 1 (cdk-1) and cdk-2 (required for cell cycle progression into the late G 1 /S phase) and cdk-5 (inactive in cycling cells) but not cdk-4 or cdk-6 (active at early G 1 ...
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Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Protein Is Phosphorylated by Cyclin-Dependent Kinases
... Departments of Microbiology and Immunology, 1 Pharmaceutical Chemistry and Medicine, 2 and Physiology 3 and Howard Hughes Medical Institute, 4 University of California San Francisco, San Francisco, California 94143 ...
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Transcription of Herpes Simplex Virus Immediate-Early and Early Genes Is Inhibited by Roscovitine, an Inhibitor Specific for Cellular Cyclin-Dependent Kinases
... Involvement of cdks in viral functions. Cellular cdks have long been known to be involved in the replication of DNA- containing viruses (21, 23, 60). For example, the replication of simian virus 40 and polyomavirus DNAs ...
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Roscovitine, a Specific Inhibitor of Cellular Cyclin-Dependent Kinases, Inhibits Herpes Simplex Virus DNA Synthesis in the Presence of Viral Early Proteins
... protein kinases which, at present, includes nine ...specific cyclin partners, phosphorylation, and interaction with cdk in- hibitors (cdis) such as p21 CIP , p27 KIP1 , p16 INK4a , and p15 INK4b , whose ...
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S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene Transcription
... of cyclin-dependent ki- nase (CDK) inhibitors that downregulated the expression of L genes without any im- pact on viral DNA replication through destabilization of the BDLF4 ...that cyclin A- and ...
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Cyclin-Dependent Kinases and CDC7 as Therapeutic Targets
... Palbociclib Induces MDM2 Knockdown and Senescence in GBM and Breast Cancer Cells Independent of p53 Status. GBM Breast Cancer[r] ...
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Investigation of the role of cyclin dependent kinases in neuronal apoptosis
... Secondly, the Cell Proliferation MTS assay (Materials and Methods section 2.2.1.7), was used to determine the viability of differentiated PC 12 cells after NGF withdrawal. PCI2 cells were plated and differentiated for 7 ...
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The PHOA and PHOB Cyclin-Dependent Kinases Perform an Essential Function in Aspergillus nidulans
... PHOA cyclin-dependent kinase (CDK) of Aspergillus nidulans plays no role in regulation of enzymes involved in phosphorous acquisition but instead modulates differentiation in response to environmental ...
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