Cyclin E/Cdk2
Drosophila double parked is sufficient to induce re replication during development and is regulated by cyclin E/CDK2
... proteins, cyclin E/CDK2 and Dbf4/Cdc7 kinases, indicating that their regulation resembles that of genomic origins (reviewed by Bandura and Calvi, ...
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Functional Interaction between the Bovine Papillomavirus Virus Type 1 Replicative Helicase E1 and Cyclin E-Cdk2
... with cyclin E- Cdk2 and is phosphorylated by this kinase in Xenopus egg extracts, we decided to develop an E1-dependent DNA replica- tion assay with Xenopus egg extracts to further investigate the ...
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Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
... Mcl-1, cyclin E levels were also higher in ABT-R compared to parental ...in Cdk2 and cyclin A, while cyclin B1 levels were decreased (Figure ...how cyclin E affects Mcl-1 ...
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A Screen for Modifiers of Cyclin E Function in Drosophila melanogaster Identifies Cdk2 Mutations, Revealing the Insignificance of Putative Phosphorylation Sites in Cdk2
... periodic expression could rescue the lethality associated three RNP-type RNA binding domains and a novel char- with the Cdk2 mutant background. As shown in Table acteristic C-terminal domain defining a family of ...
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Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity.
... Western blot analysis. The following antibodies were used at 0.5 mg/ml: anti- cyclin E antibody (HE12; Pharmingen, San Diego, Calif.), anti-p53 antibody (Ab-2; Oncogene Science, Uniondale, N.Y.), anti-p21 ...
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Expression of an S phase stabilized version of the CDK inhibitor Dacapo can alter endoreplication
... the Cyclin E-Cdk2 kinase, which must alternate between periods of high (S phase) and low (G phase) activity in order for endocycling cells to achieve repeated rounds of S phase and ...of ...
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Index Catalog // Carolina Digital Repository
... between Cyclin E/Cdk2 activity and cell cycle- regulated histone mRNA biosynthesis in Drosophila embryos, which have provided fundamental insights into the regulation of the cell cycle and how this ...
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Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
... active cyclin D1–Cdk4 com- plexes, potentially decreasing the p27 available for cyclin E–Cdk2 inhibition ...to cyclin E–Cdk2 ...increased cyclin D1 or ...of ...
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Overexpression p21WAF1/CIP1 in suppressing retinal pigment epithelial cells and progression of proliferative vitreoretinopathy via inhibition CDK2 and cyclin E
... of CDK2 (forward primer: 5′-ATC CGC CTG GAC ACT GAG-3′; reverse primer: 5′-GTG GAG GAC CCG ATG AGA-3′; 273 bp), of cyclinE (for- ward primer: 5′-TTC CAC ACA GGA GCA AAG TAT G-3′; reverse primer: 5′-TGC AAC TTT GGA ...
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Overexpression of p21waf1 in Human T-Cell Lymphotropic Virus Type 1-Infected Cells and Its Association with Cyclin A/cdk2
... of cyclin/cdk’s, depending on the cell line tested, including cyclin D/cdk4, cyclin B1/cdc2, cyclin E/cdk2, and cyclin A/cdk2 (4, 29, 35), and inhibit their ...
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Original Article Expression of cell-cycle regulators is associated with invasive behavior and poor prognosis in prolactinomas
... detectable cyclin E1, and express p27Kip1 ...that cyclin D1 and cyclin E1 are almost undetect- able in the normal pituitary, while p16 and p27 expression levels are relatively ...and E has ...
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Overexpression of Cyclin A Inhibits Augmentation of Recombinant Adeno-Associated Virus Transduction by the Adenovirus E4orf6 Protein
... The cyclin A-cdk2 com- plex phosphorylates many proteins substrates associated with cell cycle progression and DNA ...the cyclin E-cdk2 complex would not go through a successful ...
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Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... the cyclin kinase inhibitor p27 Kip1 (p27) in limiting proliferation has been ...expression. Cyclin A–cyclin-dependent kinase 2 (CDK2) activity, but not cyclin E–CDK2 ...
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The role of cyclin D2 and p21/waf1 in human T cell leukemia virus type 1 infected cells
... with cyclin D2 is the sequestration of p21/waf1 away from cyclin E/cdk2 complexes ...increased cyclin E/cdk2 associated kinase activity observed in HTLV-1 infected cells ...
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G1/S phase cyclin dependent kinase overexpression perturbs early development and delays tissue specific differentiation in Xenopus
... of cyclin E can result in cells dividing at a smaller size than usual, but the final area occupied by overexpressing cells is normal as extra cells are lost by apoptosis (Li et ...while cyclin ...
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Induction of cyclins E and A in response to mitogen removal: a basic alteration associated with the arrest of differentiation of C2 myoblasts transformed by simian virus 40 large T antigen.
... inactive cdk2 forms in complexes. The active and inactive forms of cdk2 can be electrophoretically distinguished (61); therefore, we investigated whether the proportion be- tween the two forms changed in ...
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Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer
... Cyclin E is also essential in cell fate determination during Drosophila neurogenesis, where its expression drives the asymmetric division of neuroblasts into two lineages of glial and neuronal cells ...of ...
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Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... of cyclin D1 and cyclin E in one study [11], but decreased expression of the Cdk2 and cyclin E proteins and induced apoptosis in an- other study ...the cyclin ...
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Cyclin dependent kinases
... between cyclin D and Cdk4 or Cdk6 phosphoryl- ate residues Ser807 and Ser811, priming Rb for further phosphorylation by these or other CDKs at other sites ...of Cdk2 might also contribute to this process, ...
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Identifying substrates of CDK2: cyclin A.
... of cyclin to which it is ...of cyclin E (and eventually cyclin A) which in complex with CDK2 lead to S-phase entry (Dynlacht et a l, ...
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