?-Cyclodextrin (?-CD)
Investigation on β-cyclodextrin production with cyclodextrin glucanotransferase from alkaliphilic Bacillus sp. ATCC 21783
... In addition, the effect of different concentrations of soluble starch on β-CD production was investigated . As shown in Figure 4, starch concentration had a strong effect on β -cyclodextrin production. Its ...
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Characterization and Solubility Studies of Mefloquinehydrochloride Inclusion Complexes with Cyclodextrin/ Hydroxypropyl -Cyclodextrin.
... Abstract- The present study aimed to improve the solubility and ultimate bioavailability of poorly soluble Mefloquinehydrochloride, an antimalarial drug by encapsulating it in α-cyclodextrin and Hydroxy propyl α- ...
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Enhancement of dissolution and bioavailability of poorly soluble Telmisartan:Designing modified cyclodextrin inclusion complexes
... modified Cyclodextrin such as sulphobutyl ether 7β-cyclodextrin (SBE7β- CD) to form an inclusion complex with telmisartan (TEL), a poorly soluble drug and its related effects on dissolution rate and ...
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Cyclodextrin Production from Amaranth Starch by Cyclodextrin Glycosyltransferase Produced by Paenibacillus macerans CCM 2012
... ecules and may trap a great variety of molecules having the size of one or two benzene rings, or even larger ones carrying a side chain of compa- rable size, to form crystalline inclusion complexes (Szejtli 1982). The ...
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The Effect of Fly Ash, Beta-cyclodextrin and Fly Ash-Beta-cyclodextrin Composites on Cement Paste’s Viscosity and Setting Times
... Abstract - The possibility of increasing the usage of Fly ash (FA) in concrete has been a subject of interest and investigation by the authors. In the previous work, a composite of Fly ash- β- cyclodextrin ...
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<p>Comparative study of β-cyclodextrin, γ-cyclodextrin and 4-<em>tert</em>-butylcalix[8]arene ionophores as electroactive materials for the construction of new sensors for trazodone based on host-guest recognition</p>
... B-cyclodextrin and γ -CD comprising seven or eight glucose units, respectively, react with many guest mole- cules to form inclusion complexes. 24,25 The mechanisms of the investigated sensors depend upon the ...
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Tissue Engineering Scaffolds with Enhanced Oxygen Delivery Using a Cyclodextrin Inclusion Complex
... Alternatively, oxygen delivery vectors can be prepared from cyclodextrin, cyclic oligosaccharides made up of six to eight glucose units with a unique shape that allows them to readily form inclusion complexes. ...
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CYCLODEXTRIN A GIFT TO PHARMACEUTICAL WORLD REVIEW
... α- cyclodextrin (Schardinger’s α-dextrin, cyclomaltohexaose, cyclohexaglucan, cyclohexaamylose, αCD, ACD, C6A) comprises six glucopyranose units, βCD (Schardinger’s β- dextrin, cyclomaltoheptaose, ...
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Effect of Drug Particle Size on Complexation, Physicochemical Properties and Dissolution of Cyclodextrin Inclusion Complexes
... In the present study, we first demonstrated the effect of drug particle size on complexation efficiency, physicochemical properties and dissolution of cyclodextrin inclusion complexes. Physicochemical ...
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Geosmin Sorption on Cyclodextrin Polymers
... The results presented in Figures 2(a) to 2(c) indicate that sorption capacities of the CDPs slightly depend on solu- tion pH. The sorption capacity varies slightly among the 3 pH values, which means that the CDPs can ...
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PREPARATION AND EVALUATION OF CYCLODEXTRIN COMPLEXATION OF ETORICOXIB
... Cyclodextrin complexes of etoricoxib (poorly water soluble COX-2 inhibitor) were prepared with the β-CD and HPβ-CD by different techniques (physical mixture, kneading and co-evaporation methods) at 1:1 and 1:2 ...
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ENHANCEMENT OF SOLUBILITY BY COMPLEXATION WITH CYCLODEXTRIN AND NANOCRYSTALLISATION
... Pulmonary administration of drugs is usually intended for local treatment of diseases. Drug degradation in the gastro intestinal tract and first-pass metabolism can be avoided by administration through lungs. There will ...
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Effect of Cyclodextrin Complexation on the Aqueous Solubility of Diazepam and Nitrazepam: Phase Solubility Analysis, Thermodynamic Properties
... The solubility enhancement of diazepam and nitrazepam in water was analyzed depending on temperature and amount of α -cyclodextrin ( α -CD), β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin ...
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Enantioseparation of penconazole, myclobutanil and triadimefon by cyclodextrin-modified micellar electrokinetic chromatography
... by cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) under acidic condition was investigated with different HP-γ-CD concentrations as chiral ...
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ENHANCEMENT OF SOLUBILITY OF EFAVIRENZ EMPLOYING β -CYCLODEXTRIN, POLOXAMER 407 AND PVP K30: PHASE SOLUBILITY AND FACTORIAL STUDIES
... β cyclodextrin (βCD), surfactant (Poloxamer 407) and PVP K30 and their concentrations on the solubility of efavirenz by phase solubility studies and to evaluate the individual main effects and combined (or ...
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Effect of cyclodextrin on postprandial blood glucose and triglycerides
... Instead of drug therapy, αCD consumption with meals may help prevent the onset of lifestyle diseases and allow easy implementation of glycemic control and lipid control in the daily diet. Buckly et al. reported an ...
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Study of the complexation behaviour of fexofenadine with ?-cyclodextrin
... Fexofenadine is a selective histamine H 1 receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin ...
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COMPEXATION OF POORLY WATER SOLUBLE DRUG WITH CYCLODEXTRIN
... cyclodextrins is relatively simple and involves treatment of ordinary starch with a set of easily available enzymes. Commonly cyclodextrin glycosyltransferase (CGTase) is employed along with α-amylase. First ...
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β-Cyclodextrin and oleic acid increase levels of dopamine and potentiates oxidative damage in young and adult rat brain
... Methyl β-cyclodextrin, which promotes cholesterol deple- tion in cell membranes in brain [22], increased dopamine and 5-HIAA amines in brain of young rats while, compared with adult animals the concentration of ...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF TELMISARTAN EMPLOYING β-CYCLODEXTRIN AND SOLUPLUS – A FACTORIAL STUDYN.Tirumalesh and K. P. R. Chowdary* DOWNLOAD/VIEW
... Telmisartan, a widely prescribed angiotensin II receptor antagonist belongs to class IΙ under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It is practically insoluble in water ...
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