cyclooxygenase-2
Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity
... Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first step in the synthesis of pros- tanoids, is associated with inflammatory diseases and carcinogenesis, which is ...
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Cyclooxygenase 2 and selenium in breast cancer
... Selenium (Se) is well known as an essential trace mineral and an essential cofactor for glutathione peroxidases (GPx), selenoprotein P, and thioredoxin reductase, which are involved in scavenging free radicals and ...
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Cyclooxygenase 2 Expression Is Related to the Epithelial to Mesenchymal Transition in Human Colon Cancers
... Fig. 2. Effects of PMA on the expressions of E-cadherin, COX-2, Snail and 15- PGDH, and cell mobility in HCT8 and ...COX-2, cyclooxygenase-2; GAPDH, glyceraldehydes 3-phosphate ...
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Cyclooxygenase 2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta Analysis
... A literature research was conducted using PubMed and Web of Science up to December 2012 without language re- strictions. Relevant studies were identified using the terms: (‘cyclooxygenase-2 or COX-2 ...
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Induction of cyclooxygenase 2 in human umbilical vein endothelial cells by lysophosphatidylcholine
... induces cyclooxygenase-2 mRNA and protein ...of cyclooxygenase-2 is accompanied by the enhancement of both basal- and calcium ionophore A23187-induced synthesis of ...the ...
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Cyclooxygenase/lipoxygenase shunting lowers the anti cancer effect of cyclooxygenase 2 inhibition in colorectal cancer cells
... by cyclooxygenase (COX), is implicated in the colorectal cancer (CRC) ...of cyclooxygenase-2 ...by cyclooxygenase inhibition and to determine if this process antagonizes the anti-cancer effect ...
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Angiotensin II attenuates renal cortical cyclooxygenase 2 expression
... Prostaglandins regulate vascular tone and salt and water homeostasis in the mammalian kidney and are involved in the mediation and/or modulation of hormonal action. Under basal conditions, inhibition of cyclooxy- genase ...
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Immunohistochemical and functional correlations of renal cyclooxygenase 2 in experimental diabetes
... imental model of inflammation, and COX-1 involve- ment was assessed by the incidence of development of lesions in gastric mucosa. The selectivity of NS398 has not been sufficiently tested in hemodynamic and renal ...
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A QSAR Study of 3, 4 Diaryloxazolones as Cyclooxygenase 2 Inhibitors
... A Quantitative Structure Activity Relationship (QSAR) study of 3, 4-Diaryloxazolones has been performed to evaluate the descriptors responsible for the COX-2 inhibitory activity of the molecules. The molecular ...
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Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death
... COX- 2 in knockout mice decreases neuronal death following excitotoxic challenge ...COX- 2 were present in excitotoxicity of oligodendrocytes, we would predict that expression of COX-2 in ...
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Association of Cyclooxygenase 2 Gene Polymorphism in Irritable Bowel Syndrome.
... weight loss and/or rectal bleeding should stimulate investigation of alternative diagnoses. Experimental evidence suggests that chronic inflammation following acute bacterial infection has a pathophysiological role in ...
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The Role of MicroRNAs in Cyclooxygenase-2 Mediated Breast Cancer Progression
... For RNA extraction and complementary DNA (cDNA) synthesis, cells were grown to 80-90% confluence, trypsinized and collected as cell pellets. Total RNA was extracted using the miRNeasy Minikit (Qiagen, MD) following the ...
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Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism
... manner, which in turn interacted with its EP2/4 receptors in an autocrine/paracrine fashion. The same group has also shown that activation of EP2/4 receptors led to an increase in secondary messenger cyclic adenosine ...
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PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model
... However, COX-2 is located inside the membrane of the endoplasmic reticulum. Consequently, radiotracers need to cross various biological membranes to reach the COX- 2 binding site. For this purpose, a ...
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Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study
... Elevated levels of COX-2 were also observed in the majority of dysplastic squamous epithelia and SCC, in contrast to the weak expression detected in normal esophageal tissue [14]. Another study reported ...
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Metal Enhanced Electrochemical Cyclooxygenase-2 (COX-2) Sensor for Biological Applications
... Pain measurement is commonly required in biomedical and other emergency situations, yet there has been no pain biosensor reported in literature. Conventional approaches for pain measurement relies on Wong-Baker face dia- ...
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Cyclooxygenase-2-Dependent Bronchoconstriction in Perfused Rat Lungs Exposed to Endotoxin
... formation and LPS-induced bronchoconstriction were prevented by treatment with the unspecific COX inhib- itor acetyl salicylic acid, the specific COX-2 inhibitor CGP-28238, dexamethasone[r] ...
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Host cyclooxygenase 2 modulates carcinoma growth
... We found high levels of COX-2 mRNA expressed in stromal fibroblasts of both human and rodent col- orectal cancers (20). It is clear from these results that COX-2 is expressed in both epithelial and tumor ...
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Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase 1 or cyclooxygenase 2
... ing of acetic acid–induced gastric ulcers in mice (29). Selective COX-2 inhibitors have no effect on small intestinal crypt survival after irradiation in mice (9). The absence of involvement of COX-2 in ...
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Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2
... has been associated with tumor differentiation, tumor size, stage, and metastasis. In several cancers, patients with COX-2 overexpression have a poor prognosis [10-14]. Denkert et al. immunohistochemically ...
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