Cyclooxygenase-2 inhibitor
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
... cyclooxygenase-2 inhibitor could protect neurons when applied several hours after ...this cyclooxygenase-2 inhibitor are also seen if administrated 12 h after ischemia ...
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Cyclooxygenase 2 inhibitor celecoxib attenuates joint contracture following immobilization in rat knees
... There are several limitations to the study. First, we ob- served the effects of joint immobilization and celecoxib treatment on joint contracture formation at only one time point. However, changes in the degree of ...
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Association of maternal pancreatic function and foetal growth in rats treated with DFU, a selective cyclooxygenase-2 inhibitor
... It has also been reported that COX-2 inhibition reduces the severity of pancreatitis and pancreatitis- associated lung injury [1, 10, 11]. With results simi- lar to our data, Alhan et al. [1] demonstrated that ...
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Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in Vitro and in Vivo
... MCF-7 cell was purchased from the Shanghai Institute of Cell Biology at the Chinese Academy of Sciences (Shanghai, P.R.China). RPMI1640 medium (Gibco, USA); Fetal bovine serum(Gibco, USA); 7,12-dimethylbenanthracene ...
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Cyclooxygenase 2 Inhibitor Reduces Hepatic Stiffness in Pediatric Chronic Liver Disease Patients Following Kasai Portoenterostomy
... than 2 years of age and who reported to our outpatient clinic for management of their BA after Kasai ...than 2 years of age, patients younger than 2 years were excluded from both ...
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Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids
... Cells were lysed with cell-lysis buffer. The timing of protein- sample extraction was 48 hours after drug exposure. Cells were grown in RPMI 1640 medium supplemented with 10% fetal bovine serum. Equivalent amounts of ...
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SYNTHESIS, BIOLOGICAL EVALUATION, AND DOCKING STUDY OF NOVEL 2 PHENYL 1 BENZOPYRAN 4 ONE DERIVATIVES AS A POTENT CYCLOOXYGENASE 2 INHIBITOR
... in 2-phenyl-1-benzopyran-4-one moiety with its ...with 2-chloro, 4-chloro, and 2,4-dichloro groups were possess a great efficacy in anti- inflammatory activity and act as an anti-proinflammatory ...
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miR-21 inhibits the effects of cyclooxygenase-2 inhibitor NS398 on apoptosis and invasion in gastric cancer cells
... COX-2 inhibitor NS398 (Cayman Chemical Company, Ann Arbor, MI, USA) dissolved in RPMI-1640 medium (0, 50, and 100 µ M/L) was added to AGS cells inoculated into a six-well ...
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Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat
... Depending on the experimental conditions, the temporal evolution of ischemic damage may vary considerably [30,40,41]. Thus, it is very important to characterize the time course of brain damage, especially if one wants to ...
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Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2
... has been associated with tumor differentiation, tumor size, stage, and metastasis. In several cancers, patients with COX-2 overexpression have a poor prognosis [10-14]. Denkert et al. immunohistochemically ...
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Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
... brain (Nogawa et al. 1997), was determined using a commercial enzyme immunoassay kit (RPN 222, Amersham Pharmacia Biotech Inc., Piscataway, NJ, USA) according to the instructions of the manufacturer. Unanesthetized ...
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Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
... selective cyclooxygenase- 2 inhibitor nimesulide on the number of surviving neurons in the CA1 hippocampal subfield 7 days after 5 min transient global cerebral ischemia in Mongolian ...
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Effects of intracerebroventricular injection of vitamin B12 on formalin-induced muscle pain in rats: Role of cyclooxygenase pathway and opioid receptors
... used diclofenac (cyclooxygenase inhibitor) and naloxone (opioid receptors antagonist) to clarify the possible mechanisms. For ICV injections, a guide cannula was implanted in the left lateral ventricle of ...
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<p>Can a cyclooxygenase inhibitor be an option for treatment of ovarian hyperstimulation syndrome?</p>
... The cause of OHSS, which is known to occur after fertility treatments, has not been precisely established. This has led to the investigation of possible mechanisms. In this context, the author aimed to investigate the ...
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Current biomarkers of canine mammary tumors
... In veterinary medicine, some studies have shown that the expression of one or both receptors was more fre- quent in benign tumors, and in general, its expression was related to a more favorable prognosis [87, 89, 91]. ...
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Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?
... Such a benefit was also shown in an open-label study on the combination of rizatriptan with the COX-2 inhi- bitor rofecoxib. The combination reduced recurrence rates compared to rizatriptan monotherapy, [29]. A ...
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Anti inflammatory effects of Polygonum minus (Huds) extract (Lineminus™) in in vitro enzyme assays and carrageenan induced paw edema
... The test was conducted according to method based on previous published study [30]. Briefly, 0.1 ml carra- geenan was injected into the sub-plantar region of the left hind-paw of each rat. The volume (ml) of induced edema ...
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Cyclooxygenase 2 and selenium in breast cancer
... Selenium (Se) is well known as an essential trace mineral and an essential cofactor for glutathione peroxidases (GPx), selenoprotein P, and thioredoxin reductase, which are involved in scavenging free radicals and ...
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Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets
... For example, di ff erences in the transporter and enzyme expression may eventually result in interspecies variations in brain delivery of prodrug and the release of parent drug, respectively. While limited information ...
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Induction of cyclooxygenase 2 in human umbilical vein endothelial cells by lysophosphatidylcholine
... induces cyclooxygenase-2 mRNA and protein ...of cyclooxygenase-2 is accompanied by the enhancement of both basal- and calcium ionophore A23187-induced synthesis of ...the ...
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