Cyclosporine A (CsA)
A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations
... of CsA such as nephrotoxicity, cholestasis, hypertension, hirsutism, and neuropathy are common, even with careful monitoring of the ...of CsA could be reduced by topical application, minimizing the side ...
12
Colon-targeted delivery of cyclosporine A using dual-functional Eudragit<sup>®</sup> FS30D/PLGA nanoparticles ameliorates murine experimental colitis
... Results: PNPs exhibited a burst drug release of .60% at pH 1.2 (stomach pH) in 0.5 h, which can lead to unwanted systemic absorption and side effects. ENPs effectively inhibited the burst drug release at pH 1.2 and 6.8 ...
16
Efficacy and safety of cyclosporine a for patients with steroid-resistant nephrotic syndrome: a meta-analysis
... literature were read for further screening. Discordant opinions were discussed and resolved by other reviewers. The extraction data included the (1) the first author and publication year, (2) study design features, (3) ...
8
Clinically relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion
... Methods: Isolated Langendorff-perfused rat hearts were treated sequentially with 5 nM Iso and 30 μ M Ade followed by different durations of washout prior to 30 min global ischaemia and 2 hrs reperfusion. Reperfusion ...
13
Efficacy and safety of calcineurin inhibitor treatment for IgA nephropathy: a meta-analysis
... Two researchers (GYC and YHS) performed a systematic literature search using the PubMed, Embase, Science Citation Index, Ovid evidence-based medicine, Chinese Biomedical Literature (CBM) and Chinese science and ...
9
Metastatic Merkel cell carcinoma and myasthenia gravis: contraindication for therapy with immune checkpoint inhibitors?
... Case presentation: A 61-year-old woman with a history of MG since 2005 was treated with azathioprine and pyridostigmine after thymectomy. In March 2016, she was diagnosed with MCC. Six months later the tumor had ...
6
Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus
... 10), cyclosporine A (CsA; n = 6), tacrolimus (FK506; n = 1), leflunomide (LEF; n = 2), myco- phenolate mofetil (MMF; n = 8), methotrexate (MTX; n = 8)), and 59 were receiving an antimalarial drug (chloro- ...
11
Clearing the complexity: immune complexes and their treatment in lupus nephritis
... Abbreviations: AZA, azathioprine; bid, twice daily; CRF, chronic renal failure; CRR, complete renal response; CSA, cyclosporine A; CYC, cyclophosphamide; eSRD, end s[r] ...
12
Cyclophilins: The Structure and Functions of an Important Peptidyl-prolyl Isomerase
... Cyclophilins can act as foldases or chaperones. They possess peptidyl-prolyl isomerases (PPIase) activity, which is inhibited by cyclosporine A (CsA). Their PPIase activity makes them be able to accelerate ...
6
Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study
... Abbreviations ANA: Antinuclear antibody; anti-dsDNA: Anti-double-stranded DNA antibody; BILAG: British Isles Lupus Assessment Group; BlyS: B-lymphocyte stimulator; CsA: Cyclosporine A; C[r] ...
14
Mesenchymal stem cells overexpressing IL-35: a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance
... In 2002, Bartholomew et al. [36] observed that MSCs could suppress lymphocyte proliferation in vitro and in vivo. Administration of MSCs led to prolonged skin graft survival in baboons when compared to control animals ...
8
Invasive mycoses in patients with connective tissue disease from Southern China: clinical features and associated factors
... (1/197) in SSc, and 0.4% (3/728) in PM/DM. Proven in- fection accounted for 18.8% (6/32) of the cases, and probable infection for 81.3% (26/32). All patients were of Chinese Han ethnicity. Of the 32 patients enrolled, ...
9
Mycophenolic Acid Absorption Profiles in Patients with Kidney or Combined Pancreas Kidney Transplantation
... in cyclosporine A (CsA) or tacrolimus (Tac)-based immunosuppression for renal transplant patients, but also after liver, heart, and simultaneous pancreas-kidney transplantation ...of cyclosporine and ...
7
Mesenchymal stem cell-based therapy in kidney transplantation
... and cyclosporine-resistant GVHD with ...low-dose cyclosporine A (CsA) reversed the protective influence of CsA and accelerated allograft re- jection ...low-dose CsA, MSCs could not ...
7
Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
... Finally, cyclosporine A (CsA) was used as an illustrative case to support applicability of zebrafish embryo in hepatotoxicity testing by comparing CsA-induced gene expression between [r] ...
124
Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
... inhibitor Cyclosporine A (CsA) accumulated more of the P-gp substrate Rhoda- mine 123 (R123) than non-CsA-treated cells, indicating that P-gp is active in these ...with CsA inhibition (Fig. ...
10
Systems toxicology: real world applications and opportunities
... EMBL; CsA, cyclosporine A; EBI, European Bioinformatics Institute; EMBL, European Molecular Biology Laboratory; EURL ECVAM, European Union Reference Laboratory for Alternatives to Animal Testing; GIVIMP, ...
13
Clinical utility of cyclosporine (CsA) ophthalmic emulsion 0.05% for symptomatic relief in people with chronic dry eye: a review of the literature
... bid CsA dosing were treated with off-label use of 3–4 times a day ...of CsA, they did not demonstrate a definite dose–response relationship; therefore, the FDA approval was set at bid ...
10
Association of IL1 beta gene polymorphism and allograft functions in renal transplant recipients :a case control study from Kashmir Valley
... Patients with other reasons (other than immunological cause) for transplant rejection or failure like Technical Problems, Graft failure due to any drug(like NSAIDS, herbal medications and other nephrotoxic drugs),or dye ...
6
Drug-induced gingival hyperplasia: a retrospective study using spontaneous reporting system databases
... Drug-induced gingival hyperplasia (DIGH) is a peri- odontal side effects of certain drugs, causing swelling, bleeding, and problems with chewing, aesthetics, and pronunciation. In more severe cases, it can cause high ...
11