Cytosolic DNA
AIM2 Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA
... in cytosolic DNA ...reverse-transcribed DNA generated during murine leukemia virus (MLV) infection of macrophages was sensed by cGAS, DEAD box helicase 41 (DDX41), and the mouse ALR IFI203 (39, ...
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Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1
... nonredundant DNA- binding protein. Unlike other cytosolic DNA sensors, IFI16 shuttles between the nucleus and the cytoplasm and is predominantly nuclear, with only a small fraction being detected in ...
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Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways
... nonself DNA molecules or DNA-containing ...cluding DNA-dependent activator of IFN regulatory factors (DAI) (12, 13), absent in melanoma 2 (AIM2) (14–16), the mem- ber of the PYHIN protein family ...
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Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1
... of cytosolic DNA species, including the genomes of viruses such as herpes simplex virus 1 ...numerous DNA pathogens, sustained STING activity can lead to lethal inflammatory ...
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Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish
... mammals, cytosolic RNA and DNA viruses are sensed/rec- ognized by their corresponding receptors, which ultimately acti- vate the IRF3- and/or NF- B-responsive genes, including type I interferons (IFNs) ...
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How does Vaccinia virus inhibit the detection of cytosolic DNA by the innate Immune system?
... a DNA-dependent protein kinase catalytic subunit (DNA-PKcs) (Ferguson et ...alongside DNA- PKcs to directly bind DNA (Walker et al., 2001). DNA-PKcs can bind DNA in the absence ...
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Recognition of Cytosolic DNA Attenuates Glucose Metabolism and Induces AMPK Mediated Energy Stress Response
... and DNA transfection expose single-stranded or double-stranded DNA to the cytoplasm of mammalian ...of cytosolic DNA activates a series of cellular re- sponses, including induction of ...
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Hsia_unc_0153D_16731.pdf
... that cytosolic DNA restrains STAT3 activation by S754 phosphorylation raises several important questions: When and where does this occur in vivo, and what are the consequences? One possible scenario that ...
137
Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease
... of cytosolic DNA, assemble the Aim2/AIM2 inflammasome, resulting in activation of caspase-1, pyroptosis, and the secretion of pro-inflammatory cytokines ...
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Serum cytokine profiling analysis for zheng differentiation in chronic hepatitis B
... interaction, cytosolic DNA‑sensing pathway, and chemokine signaling pathway overlapped between LGDH and LKYD, whereas Toll‑like receptor signaling pathway, intestinal immune network for IgA production, ...
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Dietary antioxidants protect gut epithelial cells from oxidant induced apoptosis
... cellular DNA fragmentation ELISA. Cell death was characterized by measuring DNA fragments released into the medium (early necrosis and late apoptosis), and apoptosis (DNA fragments in the ...genomic ...
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Beyond sensing DNA:A role for cGAS in the detection of extracellular cyclic di nucleotides
... of cytosolic DNA, as the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS) produces a mammalian cyclic di-nucleotide, cyclic GMP-AMP (cGAMP), that also activates STING ...
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6108.pdf
... elucidating cytosolic DNA recognition and downstream signaling ...intracellular DNA sensor that activates type I interferon production through its interaction with TANK-binding kinase 1 ...recognizes ...
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Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
... STING is required for EV-DNA-dependent gene induction. Having established the effect of EV-DNA within monocytes, we wanted to establish whether the host response to the P. falci- parum EV-DNA was ...
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Malaria parasite DNA harbouring vesicles activate cytosolic immune sensors
... STING is required for EV-DNA-dependent gene induction. Having established the effect of EV-DNA within monocytes, we wanted to establish whether the host response to the P. falci- parum EV-DNA was ...
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Suppression of a Defect in Mitochondrial Protein Import Identifies Cytosolic Proteins Required for Viability of Yeast Cells Lacking Mitochondrial DNA
... mitochondrial DNA (mtDNA). We identified several genes encoding cytosolic proteins, including CCT6, SSB1, ICY1, TIP41, and PBP1, which, when overproduced, rescue the mtDNA dependence of tim18⌬ ...
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Nitric oxide synthase activity in human trophoblast, term placenta and pregnant myometrium
... only cytosolic (supernatant) activity was analysed in their samples ...the cytosolic fraction, but the former was not analysed in the study by Ramsay et al ...in cytosolic fraction is by and large a ...
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ALLOZYME SEGREGATION RATIOS IN THE INTERSPECIFIC CROSS CUCURBITA MAXIMA x C. ECUADORENSIS SUGGEST THAT HYBRID BREAKDOWN IS NOT CAUSED BY MINOR ALTERATIONS IN CHROMOSOME STRUCTURE
... The locus coding the segregating cytosolic isozyme was given the “c-2” suffix because a second, more anodal, cytosolic form gave faint activity in leaf extracts and could be[r] ...
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Adenosine triphosphate depletion induces a rise in cytosolic free calcium in canine renal epithelial cells
... An elevation in cytosolic free calcium (Cai) produced by cellular ATP depletion may contribute to the initiation of cytotoxic events in renal ischemia. To evaluate whether ATP depletion results in a rise in Cai we ...
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Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development
... light-responsive DNA-binding with one fin- ger boxes (Dof-boxes [46] at nucleotide positions − 490/ − 486, − 421/ − 417 and − 353/ − 349 in Figure 4A), soya bean em- bryo factors SEF1 ( − 158/ − 150 and − 136/ − ...
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