cytotoxic CD8+ T lymphocyte
Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV 1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
... ⫹ T cells in persons on cART is the major barrier to curing HIV-1 infection ...dysfunctional T cells ...naive CD8 ⫹ T cells through selective programming of the DC pathway and presenta- tion ...
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Interleukin-4 Diminishes CD8+ Respiratory Syncytial Virus-Specific Cytotoxic T-Lymphocyte Activity In Vivo
... In this report, we show that IL-4 production during CTL development diminishes the expansion and activity of both primary and memory M2-specific CTL in vivo. We developed a system to evaluate the local cytokine effects ...
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Decreased CXCR3+ CD8 T Cells in Advanced Human Immunodeficiency Virus Infection Suggest that a Homing Defect Contributes to Cytotoxic T-Lymphocyte Dysfunction
... of CD8 T cells from HIV-infected lymph nodes have described the majority of cells as having an effector/memory phenotype— ...⫹ CD8 T cells were significantly enriched in the lymph nodes ...
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Human Cytotoxic T-Lymphocyte Repertoire to Influenza A Viruses
... Isolation of influenza A virus-specific CTL lines from donor 1. This bulk culture of influenza A virus-specific CTLs and sub- sequently two others from this donor were cloned by limiting dilution, and wells positive for ...
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Capillary blood as an alternative specimen for enumeration of percentages of lymphocyte subsets
... of T-cells (CD3+), helper T-cells (CD4+), cytotoxic T-cells (CD8+), B-cells (CD19+), and NK-cells (CD56+) from both venous and capillary blood were highly correlated ...regulatory ...
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De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection
... novel CD8 ⫹ T-cell responses against CTL escape variants that affect TCR recognition, using epitope-specific CD8 ⫹ T cells expressing a different TCR ...HIV-1-specific CD8 ⫹ ...
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Cytotoxic T lymphocyte responses against melanocytes and melanoma
... MAA-specific CD8+ T cells were observed in high percentages in both tumor and vitiligo lesions, supportive of the hypothesis that vitiligo may not be uncoupled from anti-tumor effect, and even indi- cative ...
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Immunologic abnormalities in chronic fatigue syndrome
... Font, Ophthalmology, in press; T8 CD8 or suppressor-cytotoxic T cells 40 plus 12-PE to measure human lymphocyte antigen HLADR activation antigen 41 expression on CD8; B1-FITC CD20 and B2[r] ...
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Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens.
... Therefore, the B-LCL targets were infected with HSV-2, IL-2 was added to 32 U/ml final concentration, and the cells were incubated overnight in parallel with untreated or acyclovir-treat[r] ...
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Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone.
... 7540-7545 0022-538X/94/$04.00+0 Copyright C 1994, American Society for Microbiology Apoptosis Induced in Mouse Hepatitis Virus-Infected Cells by a Virus-Specific CD8+ Cytotoxic T-Lymphoc[r] ...
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Identification of CD8+ cytotoxic T lymphocyte epitopes from porcine reproductive and respiratory syndrome virus matrix protein in BALB/c mice
... of CD8 + T cell responses during PRSSV infection and ...by cytotoxic T cells in different animal ...by cytotoxic T cells of both mice and humans ...
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Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis
... CTL, CD8+ cytotoxic T lymphocyte; FHL, familial hemophagocytic lymphohistiocytosis; GS2, Griscelli syndrome type II; HLH, hemophagocytic lymphohistiocytosis; NK, natural killer; SAP, signaling ...
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Cytotoxic T lymphocyte responses to Ras protein
... allospecific T cells to proliferate and secrete IFN-y ...CD4+ T cells, increasing their ...a t expression of Ras does not affect levels of cell surface class I MHC ...stimulate CD8+ T ...
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Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.
... Specific lysis of human immunodeficiency virus type 1-infected cells by a HLA-A3.1restricted CD8+ cytotoxic T-lymphocyte clone that recognizes a conserved peptide sequence within the gp4[r] ...
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B7 Costimulation Is Critical for Antibody Class Switching and CD8+ Cytotoxic T-Lymphocyte Generation in the Host Response to Vesicular Stomatitis Virus
... of T cells is important in the generation of immune ...enhances T-cell re- sponses, and perhaps unique among the costimulators, the B7 molecules can prevent induction of anergy ...
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Tim-3 expression and its role in hepatocellular carcinoma
... CTLA-4: Cytotoxic T lymphocyte-associated protein 4; CTLs: CD8+ cytotoxic T lymphocytes; DC: Dendritic cell; EMT: Epithelial-mesenchymal transition; EpCAM: Epithelial cell ...
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The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity
... + T cell-mediated auto- immune responses to MOG ...+ T cells and by promoting myelin repair and neural cell de- velopment ...Because CD8 + T cells can further directly mediate motor disability ...
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Lymphocyte apoptosis in children with central nervous system tuberculosis: a case control study
... Our study suggests that TB infection in children increases the sensitivity of CD4 + T lymphocytes to apop- tosis and causes a decrease in CD8 + activated T lympho- cytes. Interestingly, chemotherapy ...
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Circulating cytotoxic CD8+ CD28 T cells in ankylosing spondylitis
... undergone more consistent immunosuppressive therapy and thus have an iatrogenic risk for CMV and EBV infec- tions. Most of our AS patients, however, cannot be con- sidered to be immunosuppressed, except for the fact that ...
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Feeding of the probiotic bacterium Enterococcus faecium NCIMB 10415 differentially affects shedding of enteric viruses in pigs
... 1 st quartile and above the 3 rd quartile were identified as outliers (less than 1% of all data). All outliers were then removed from subsequent analyses. The data were ana- lyzed applying the general linear model and ...
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