db/db mice
Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron specific LEPR B transgenes
... in db/db mice with SYN-LEPR-B and NSE-LEPR-B ...in db/db mice. Male Syn db/db mice showed an improvement in all measures of diabetes (Table 1 and Figure 6), ...
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Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists A novel treatment strategy
... diabetic db/db mice and their nondiabetic db/m littermates were treated with eight consecutive weekly injections of 150 micrograms of A717 (Fab fragments) to reduce the elevated plasma ...
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Combined effect of hyperfiltration and renin angiotensin system activation on development of chronic kidney disease in diabetic db/db mice
... of db/db mice, we treated them with ARB or the vasodilator hydralazine, which lowered blood pressure to levels similar to those observed in db sham mice without significant changes in ...
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Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
... in db/db mice, dietary supple- mentation with curcumin diminished mitochondrial dys- function, likely by decreasing lipid peroxidation, which results in an increase of ATPase activity, restoration of ...
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Oral Quercetin Supplementation Lowers Plasma sICAM 1 Concentrations in Female db/db Mice
... bution of adipose tissue has been observed in rodents as well as in humans [35]. Present data suggests that the type of adipose tissue has an impact on adipokine secre- tion and insulin sensitivity and thus might be more ...
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Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice
... the db/db ...C57Bl/6 mice (Figure ...treated mice compared to the non-treated ones (Figure 4), making the possibility of dextran-binding by metformin very ...the db/db ...treated ...
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Original Article Increased SPARC expression in skeletal muscle and adipose tissue of db/db mice
... Figure 4. Immunofluorescence analysis of SPARC in skeletal muscle (A) and adipose tissue (B). Fixed tissues were permeabilized for 5 min in PBS con- taining 0.1% Triton X-100. Tissues were re-washed with PBS and ...
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Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice
... The lower liver weight coefficient of mice in the BBR- SLN 100 mg/kg group was first observed. TG is thought to be a surrogate marker of disrupted insulin signal. We demonstrated that, after being entrapped into ...
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Metabonomic profiles delineate potential role of glutamate-glutamine cycle in db/db mice with diabetes-associated cognitive decline
... in db/db mice with DACD, which was in agree- ment with the findings from semi-quantitative immuno- histochemistry about the key proteins alterations in glutamate-glutamine ...of db/db ...
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Glycemic improvement in diabetic db/db mice by overexpression of the human insulin regulatable glucose transporter (GLUT4)
... hGLUT4 db/db mice showed elevated plasma membrane-associated GLUT4 protein in the basal state, which markedly increased after an insulin/glucose ...nontransgenic db/db mice had ...
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Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy
... in db/db mice, E-cadherin and α -SMA protein expression were detected by immunohistochemistry and Western blot (Figure 5A–C, F, and ...the db/m group, E-cadherin was significantly reduced in ...
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Original Article Partial hepatectomy promotes pancreatic regeneration through HGF/Gab1 pathway in db/db mice
... phorylation [27]. A more specific study demon- strated that HGF stimulated a 3-fold increase in membrane Gab1association with c-Met, Grb2, SHP2, PI3K, Shc, Crk isoforms and CrkL. It showed that Gab1 activation plays a ...
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Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice
... decreased in the WAT of db/db and HFD mice [26]. In addition, they showed that metformin increased the AMPK activity in the WAT of db/db mice and in adipocytes trea- ted with ...
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The loss of GLUT2 expression by glucose unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment
... diabetic mice were, however, mostly unaltered. Transplanting islets from db/db mice under the kidney capsule of db/+ mice restored normal GLUT2 ...of db/+ islets into ...
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Comparison of Rosiglitazone and Metformin in Genetically Obese and Diabetic db/db Mice and Streptozotocin-Induced Diabetic Rat Models.
... in db/db mice ...The db/db mice model is an insulin resistance model; there is more amount of insulin that is synthesized and the concentration of insulin is increased and it ...
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Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression
... Notes: The mice were subcutaneously injected liraglutide or saline at 8 weeks old. (A) effect of liraglutide on the body weight of mice. (B) an average relative body weight gain was calculated by ...
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<p>Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice</p>
... in mice through the modulation of AT-1R/MAPK pathway, 16 in both of which the rodent models of type 1 diabetes were ...in db/db mice, a type 2 diabetic murine model, 20 have not yet been ...in ...
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Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice
... subordinate db/db mice showed a systemic low- grade pro-inflammatory profile, as suggested by elevation of TNF-alpha levels and mild increase in IL-6 levels, in line with results in wild-type ...
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The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice
... Lepr db /+Lepr db /Jcl (db/db) mice and their non-diabetic heterozygous control littermates ...Cg-m+/+Lepr db /Jcl (db/+) mice were purchased from CLEA Japan ...
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Evidence against a role for NLRP3 driven islet inflammation in db/db mice
... all mice at termination of the intervention and assessed circulating levels of MCC950 using liquid chromatography-tandem mass ...both db/þ and db/ db treated groups as expected (Supplementary ...
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