Dectin-2
TLR4, but neither dectin 1 nor dectin 2, participates in the mollusk hemocyanin induced proinflammatory effects in antigen presenting cells from mammals
... chimeric Dectin-1 and Dectin-2 receptors in vitro in a glycan- dependent ...to Dectin-1 but not to ...to Dectin-2 (64, ...to Dectin- 2 but a partial loss binding to ...
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Dectin-2-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy
... mannans. Dectin-2 is a mammalian innate im- mune membrane receptor that binds as a dimer to mannans and signals fungal in- ...of Dectin-2’s mannan-binding domain, ...liposomes. ...
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Saccharomyces cerevisiae mannan induces sheep beta-defensin-1 expression via Dectin-2-Syk-p38 pathways in ovine ruminal epithelial cells
... a Dectin-2-dependent man- ner [22]. Dectin-2 is a newly discovered C-type lectin receptor, which is mainly expressed on the surface of various macrophages and dendritic ...cells. ...
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Dectin 2–induced CCL2 production in tissue resident macrophages ignites cardiac arteritis
... Some limitations in the present study need to be considered. First, although the CAWS-induced vasculitis model is considered a representative animal model of KD (11, 12, 55), like all other ani- mal disease models, it is ...
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Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients
... human Dectin-2, HL-60 cells, hu- man PBMCs, primate PBL cells, and mouse BMDCs were stained with anti-Dectin-2 MoAbs (1 μg/10 6 cells) at 4 °C for 30 ...of 2 and 10 min, respectively. ...
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Phospholipase Cγ2 is critical for Ca2+ flux and cytokine production in anti-fungal innate immunity of human corneal epithelial cells
... as Dectin-1 could elicit intracellular Ca 2+ flux ...Ca 2+ flux with the engagement of Dectin-1in DCs ...Ca 2+ homeostasis was in- volved in the potential mechanisms of hypoxia-induced ...
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Dectin-1/2-induced autocrine PGE(2) signaling licenses dendritic cells to prime Th2 responses
... infected Dectin-2 −/− mice displayed lower pro- duction of Th2 cytokines IL-4 and IL-5 in both lymphoid organs in comparison to their infected WT counterparts, while IFN-γ production was not different ...
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PubMedCentral-PMC5510910.pdf
... of Dectin-1 or Dectin-2 in single receptor-deficient DCs and cells from Clec4n -/- , Clec7a -/- , and Clec7a -/- Clec4n -/- mice, we discovered that while Dectin-2 operates as a primary ...
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Dok3–protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil dependent antifungal immunity
... Flow cytometry. Cell suspensions were surface labeled with fluoro- chrome-conjugated antibodies for 10 minutes at 4°C in staining buffer (PBS containing 1% BSA). For intracellular labeling, cells were fixed and ...
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Genetic deletion of dectin-1 does not affect the course of murine experimental colitis
... if dectin-1 plays a role in the progression of intestinal ...models, dectin-1 deficient mice did not show any substantial or consistent differences in weight, colon inflammation, systemic inflammation and ...
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Original Article Effects of Dectin-1 on the mast cells in allergic conjunctivitis and its underlying mechanism
... D 2 (PGD 2 ), histamine (HIS), interleukin 4 (IL-4) and tumor necrosis factor (tumor necrosis factor-alpha, TNF-α) [15, ...PGD 2 , HIS, IL-4 and TNF-α in the serum ...
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<p>NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle Synergistically Enhance Proinflammatory Reactions Both In Vitro and In Vivo</p>
... Finally, we showed that synergy between NOD1/2 and Syk-coupled lectin receptors, which leads to enhanced acti- vation of NF- κ B, AP-1 and production of IL-8 in THP-1 cells in vitro, is also observed in vivo. ...
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Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern recognition receptors
... receptor Dectin-1 [18], complement receptor 3 (CR3) [19], scavenger receptors [20], lactosylceramide [21], TLR2 [22], and TLR4 ...these Dectin-1 plays a major role in β- glucan recognition and control of ...
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Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors
... Type of ligand-PRR interactions and pathogen-associated mo- lecular pattern concentration decides the inflammatory state of monocytes. Some microbial ligands, such as  -1,3-glucan (  -glu- can) and the muramyl ...
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Concurrent exposure to a dectin-1 agonist suppresses the Th2 response to epicutaneously introduced antigen in mice
... these, dectin-1, a C-type lectin receptor involved in the recognition of β-glucan was shown to be crucial for the control of fungal infection ...[14,15]. Dectin-1 signaling in macrophages and neutrophils ...
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PU 1 is involved in the immune response to Aspergillus fumigatus through upregulating Dectin 1 expression
... of Dectin-1 expression has not been ex- tensively studied to date; however, downregulation of ...decreased Dectin-1 expression in AMs in Pneumocystis-infected mice ...of Dectin-1 via a ...
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Yeast zymosan, a stimulus for TLR2 and dectin 1, induces regulatory antigen presenting cells and immunological tolerance
... TLR2, dectin-1, and ERK, in the therapeutic modu- lation of innate and adaptive immunity in the context of many pathologic states, such as autoimmunity, allergy, transplantation, and infectious ...
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2′ (2 Fluorobenzylidene) 2 hydroxybenzohydrazide
... The title molecule (Fig. 1) is essentially planar, with an r.m.s. deviation of 0.08 AÊ. As a result of conjugation, the C O distance [1.230 (2) AÊ] is longer than the normal value of 1.20 AÊ, and the C1ÐN1 bond ...
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2′ (2 Thienylmethylidene) 2 hydroxybenzohydrazide
... aldehyde (0.02 mol, 1.88 g) was added and the mixture re¯uxed for 2 h. The precipitate was collected by ®ltration and washed with ethanol. The product was recrystallized from ethanol and dried under reduced ...
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Dichotomization: 2 × 2 (×2 × 2 × 2...) categories: infinite possibilities
... Theory driven cutoffs may be chosen based on 1) a known dose-response relationship (i.e., the threshold where biological effects are known or postulated to start); 2) a literature review of cutoffs used in ...
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