Dendritic cell (DC)
Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma: 5-year follow up and additional analyses
... onto DC outside of the im- munosuppressive tumor environment may be especially advantageous in patients who have normal expression of major histocompatibility antigens, but have no infiltration of CD8+ ...
10
Introduction to dendritic cell vaccines immunotherapy for glioblastoma multiforme : A novel approach
... the dendritic cell (DC) vaccines therapy. As regard to post-DC vaccines therapy, the patient showed a significant improvement in her clinical condition (Karnofsky performance status increased ...
5
Eliciting cytotoxic T lymphocytes against human laryngeal cancer-derived antigens: evaluation of dendritic cells pulsed with a heat-treated tumor lysate and other antigen-loading strategies for dendritic-cell-based vaccination
... [4]. Dendritic cell (DC)-based vaccination trials have been performed for some advanced cancers, such as melanoma and colon, renal, and prostate cancers ...T cell helper ...
9
Impaired Accessory Cell Function in a Human Dendritic Cell Line after Human Immunodeficiency Virus Infection
... human dendritic cell (DC) hybridoma cell lines by fusing HGPRT-deficient promonocytic U937 cells with immature DCs obtained by culturing peripheral blood monocytes with interleukin-4 (IL-4; ...
12
Original Article Efficacy analysis of triple-negative breast cancer patients treated with dendritic cell-cytokine-induced killer cell immunotherapy
... of dendritic cell-cytokine-induced killer (DC-CIK) cell immunotherapy combine with chemotherapy with or without radiotherapy for triple-negative breast cancer (TNBC) patients following ...of ...
9
Schnorfeil, Frauke Marie (2011): MicroRNAs regulate Dendritic Cell Development and Function. Dissertation, LMU München: Medizinische Fakultät
... While pDCs and cDCs share common progenitors (section 4.1.2), pDCs possess distinct mo- lecular features resembling those of lymphocytes. pDCs are also called natural interferon- producing cells, as they produce massive ...
90
The DC-SIGN-CD56 interaction inhibits the anti-dendritic cell cytotoxicity of CD56 expressing cells
... and DC-SIGN, donor PBLs were activated, infected with HIV-1 and stained with a soluble DC-SIGN-Fc ...soluble DC-SIGN due to the cell surface expression of HIV-1 envelope glycoprotein ...
11
Galectin 9 prolongs the survival of septic mice by expanding tim 3 expressing natural killer T cells and PDCA 1+ CD11c+macrophages
... puncture; DC: Dendritic cell; ELISA: Enzyme-linked immunosorbent assay; FACS: Fluorescence- activated cell sorting; FCS: Fetal calf serum; Gal-9: Galectin-9; HMGB1: High mobility group box 1; ...
11
Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross sectional study
... B cell activating factor; BCR: B cell receptor; CpG: cytosine-phopsphate-guanosine; DC: dendritic cell; DCregs: indoleamine 2,3-dioxygenase-expressing dendritic cells; ESSDAI: ...
18
Characterization of DC-SIGN/R Interaction with Human Immunodeficiency Virus Type 1 gp120 and ICAM Molecules Favors the Receptor's Role as an Antigen-Capturing Rather than an Adhesion Receptor
... The dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin binding receptor (DC-SIGN) was shown to bind human immunodeficiency virus type 1 (HIV-1) viral ...
10
<p>T cells targeting multiple tumor-associated antigens as a postremission treatment to prevent or delay relapse in acute myeloid leukemia</p>
... immunoregulatory antibodies, vaccines, and adoptive cell infusion. 2 The direct clinical evidence of antileukemia- speci fi c cytotoxic T lymphocytes (CTLs) originated from the relapse of chronic myeloid leukemia ...
10
Local synthesis of interferon alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells
... blood dendritic cell antigen 2; DAB: 3,3 ′ -diaminobenzidine; DC: dendritic cells; DIG: digoxigenin; dsRNA: double-stranded ribonucleic acid; DTX3L: deltex 3 like, E3 ubiquitin ligase; FBS: ...
13
Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer
... immune cell therapy has emerged as a potent treatment for multiple cancers, first through groundbreaking leukemia therapy, and more recently, by tackling solid ...Assaying cell biodistribution is ...
11
Anti HER2 CD4+ T helper type 1 response is a novel immune correlate to pathologic response following neoadjuvant therapy in HER2 positive breast cancer
... Introduction: A progressive loss of circulating anti-human epidermal growth factor receptor-2/neu (HER2) CD4 + T-helper type 1 (Th1) immune responses is observed in HER2 pos -invasive breast cancer (IBC) patients ...
15
Long noncoding RNA expression profile and association with SLEDAI score in monocyte derived dendritic cells from patients with systematic lupus erythematosus
... monocyte-derived dendritic cell (moDC) maturation, 1 μg/ml lipopolysaccharide (LPS; Escherichia coli type 055:B6; Sigma) was added to the medium at day ...
11
Stage IV gastric cancer successfully treated by multidisciplinary therapy including chemotherapy, immunotherapy, and surgery: a case report
... tomography showed a thickened gastric wall and multiple lymphadenopathies including left supraclavicular lymph node. Gastroenterological endoscopy revealed tumor lesions in the gastric cardia. Tumor biopsy indicated a ...
6
Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab
... pDC cell surface and the subsequent internalization and delivery of the self-DNA or self-RNA within the complex to intracellular TLR9 or TLR7, respectively ...
10
Generation of donor specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression
... ing cell therapy under active immunosuppression is the effect of the selected drugs on Tr1-cell viability and sta- bility/function in vivo ...no cell therapy but standard immunosuppressive treatment, ...
12
Disturbance of cytokine networks in Sjögren's syndrome
... Aberrant production of BAFF by B cells in SS patients Indeed, due to the dependency of newly formed B cells on BAFF, it is tempting to believe that this cytokine needs to be produced in tissue nearby the cell ...
10
Microbes, the gut and ankylosing spondylitis
... Th e human gastrointestinal tract is not a complete barrier. It is composed of a single layer of intestinal epithelial cells (IECs), which form a physical barrier separating the intestinal lumen from the lamina propria ...
12