Dendritic cell subsets
Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
... monocyte-derived dendritic cells (MDDCs), but not DC2 cells, expressed low levels of HLA-DR ...circulating dendritic cell subsets exhibited low CD80 and CD86 expression, which is concordant ...
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Role of cervical dendritic cell subsets, co-stimulatory molecules, cytokine secretion profile and beta-estradiol in development of sequalae to Chlamydia trachomatis infection
... CD11c or CD123 molecules [25,26], but no information is available on presence and role of these subsets during chlamydial infection. In this study, median number of pDCs in the cervix was found to be significantly ...
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Dendritic cell subsets dynamics and cytokine production in SIVmac239 infected Chinese rhesus macaques
... In summary, our study revealed that the counts of mDC and pDC did not significantly change during SIVmac239 infection in Ch Rhs and had no relationship with CD4+ T cells or viral load. Poly(I:C)-induced IL-12 and HSV- ...
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Comparative analysis of circulating dendritic cell subsets in patients with atopic diseases and sarcoidosis
... pDC subsets. After a report describing two further subsets in mDCs, mDC1s as a Th1-promoting mDC subtype and mDC2s as a Th2-promoting mDC subtype [21], an increasing number of studies have been analyzing ...
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Sustained cross-presentation capacity of murine splenic dendritic cell subsets in vivo
... heterogeneous cell population in vivo where each subset has different capacities in ...APC subsets (CD8 α + DCs, CD8 α − DCs, pDCs and macrophages) in ...APC subsets take up antigen and have the ...
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Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis
... Collectively, our data suggest a functional deactivation of both MDCs and PDCs during sepsis. Recent experimental findings provided experimental evidence for a crucial role of defective DC responses for the increased ...
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Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab
... In our study, similar results were observed, with signifi- cantly lower cDC1 frequencies and an inferior activation state of cDC1, cDC2 and monocytes in mCRPC patients (see Additional file 3: Figure S3A and B). ...
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Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis
... DC subsets has been hampered by a lack of specific DC markers and reliable quantitation ...DC subsets in PB and SF from PsA patients and RA ...DC subsets in PsA and compared them with those in ...
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Impact of Varicella-Zoster Virus on Dendritic Cell Subsets in Human Skin during Natural Infection
... levels of IFN- ␣ . This study defines the repertoire of changes in the response of DC and provides evidence for the infection of specific DC subtypes during natural cutaneous VZV infection. The frequency of CD1a ⫹ ...
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Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains
... lymphocyte subsets were identified after multiparameter gating for standard surface markers (Figure ...lymphocyte subsets NK cells and γδ TCR+ lymphocytes were identified accord- ing to CD49b (CD3 neg CD49b ...
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Differential Response of Respiratory Dendritic Cell Subsets to Influenza Virus Infection
... lung cell suspensions from the control and infected mice were labeled with MAbs against surface CD11c, MHC class II, CD11b, CD103, B220, and intracellular ...RDC subsets were gated as in ...
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Type I Interferon Inhibition and Dendritic Cell Activation during Gammaherpesvirus Respiratory Infection
... plasmacytoid dendritic cells are the first dendritic cell population in the lung to show signs of activation in response to ␥ HV68 intranasal inoculation and that ␥ HV68 induces the activation of ...
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Dendritic cells in autoimmune diabetes
... In order to determine the role of dendritic cell subsets in the transfer of autoimmune diabetes, irradiated recipient mice expressing model autoantigen in the islet can be reconstituted [r] ...
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Investigations of the functional states of dendritic cells under different conditioned microenvironments by Fourier transformed infrared spectroscopy
... serum (FBS), glutamine, penicillin and streptomycin, plus 150 ng/ml recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) and 100 ng/ml recombinant human interleukin-4 (rhIL-4). After 7 days, ...
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Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model
... B cell responses ...T cell trafficking, infiltration and activation that closely matched that observed in human prostate can- ...T cell ratio with predominance of CD8+ T cells and CD8+/CD56+ NKT ...
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Schnorfeil, Frauke Marie (2011): MicroRNAs regulate Dendritic Cell Development and Function. Dissertation, LMU München: Medizinische Fakultät
... properties of different DC subsets are desirable. A major obstacle so far is the transfer of find- ings made in mouse models to the human system, as the present knowledge about human DCs is mostly derived from in ...
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Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells
... This type-I integral transmembrane protein is primarily expressed by myeloid cells such as macrophages and DCs (4, 16). The extra- cellular portion of MR consists of three regions: a cysteine-rich domain, a fibronectin ...
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The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection
... essential cell nutrient), which limited the spread of infections ...T cell regulatory effects when expressed by DCs suggests that this mechanism may be exploited to protect pathogens by suppressing host T ...
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Studies of immune functions of patients with systemic lupus erythematosus T cell subsets and antibodies to T cell subsets
... effective in eliminating suppressor function only when T cells were treated before activation; there was no effect when treatment was performed after activation. These studies indicate that the antibodies preferentially ...
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Dendritic Cell Autophagy Contributes to Herpes Simplex Virus Driven Stromal Keratitis and Immunopathology
... T cell activation, DC-au- tophagy ⫺/⫺ mice showed overall dampening of immune infiltra- tion and cytokine production in the ...mune cell in HSK lesions (73, 74), and we saw a trending reduc- tion in the ...
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