Dendritic cell vaccination
Dendritic cell vaccination for glioblastoma multiforme: review with focus on predictive factors for treatment response
... DC vaccination is clinically important and ...for vaccination other than tumor lysate will inherently restrict the approach to certain (highly selected) subgroups of ...DC vaccination has to be ...
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Cytokine responsiveness of CD8+ T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients
... DC vaccination treatment course, and as a requisite for trial eligibility, all patients were free of any concomitant medications known to affect immune cell function ...
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Preclinical exploration of combining plasmacytoid and myeloid dendritic cell vaccination with BRAF inhibition
... DC vaccination; specifically, we studied the potential off-target effects of vemurafenib on human natural blood DC subsets, which appear to be the supe- rior vehicles for DC vaccination [17, 28, ...DC ...
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Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results
... NOD/SCID mice were bought from Jackson Laboratory (Charles River). Mice manipulations were approved by the Institutional Animal Care and Use Committee of Stem Cell Research and Application Laboratory, University ...
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Adjuvant dendritic cell vaccination induces tumor-specific immune responses in the majority of stage III melanoma patients.
... However, since tumor-associated antigen TAA-specific T cells are detected in only a minority of the peripheral blood samples, and to date no correlation has been found between immunologic[r] ...
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Dendritic cell vaccination with a toll-like receptor agonist derived from mycobacteria enhances anti-tumor immunity
... splenocytes from vaccinated mice were harvested and stained with PE-conjugated CD4 and FITC-conjugated CD25 mAbs for 30 min at 4°C. Fc block was added before incubation with surface antibodies. The cells were then washed ...
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A pancreatic tumor-specific biomarker characterized in humans and mice as an immunogenic onco-glycoprotein is efficient in dendritic cell vaccination
... III in Supplementary Figure S5). *P < 0.05, ** P < 0.01; Holm-Sidak’s post-hoc test. Long-term protection provided by prophylactic DC-vaccination. B. Mice receiving prophylactic DC-vaccination and ...
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A pilot study of autologous tumor lysate-loaded dendritic cell vaccination combined with sunitinib for metastatic renal cell carcinoma
... A pilot study of DC-based immunotherapy combined with sunitinib in mRCC patients was conducted. The primary endpoints were the safety and feasibility of this approach; the secondary endpoints were to obtain immunological ...
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Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma.
... Up to April 2016, 9 patients (39%) are free of melanoma relapse and 14 patients (61%) developed metastatic disease after DC vaccination of which 12 patients have died (52%). The median disease- free survival (DFS) ...
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Dendritic cell immunotherapy versus bevacizumab plus irinotecan in recurrent malignant glioma patients: a survival gain analysis
... Patient characteristics for each study, such as number of patients, median age, sex, tumor histology, and treatment protocol, are described in Tables 1 and 2, while treatment responses (mOS, predicted mOS, survival gain, ...
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Recent developments in immunotherapy of acute myeloid leukemia
... The advent of new immunotherapeutic agents in clinical practice has revolutionized cancer treatment in the past decade, both in oncology and hematology. The transfer of the immunotherapeutic concepts to the treatment of ...
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Dendritic Cells Loaded with Tumor B Cells Elicit Broad Immunity against Murine Gammaherpesvirus 68 but Fail To Prevent Long-Term Latency
... and cell-mediated immune responses and suggest that optimal broad immunity may achieve ...protection. Dendritic cells (DC) are at the core of the immune response, and they are also the main target of ...
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Immunologic treatments for precancerous lesions and uterine cervical cancer
... renal cell carcinoma, mel- anoma, and non–small cell lung cancer, and a relation- ship between tumor cell surface PD-L1 expression and objective responses to anti-PD1 therapy ...squamous cell ...
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Dendritic cell tumor in a salivary gland lymph node: a rare differential diagnosis of salivary gland neoplasms
... For establishing the diagnosis a large number of immunohistochemical stainings and ultrastructural ana- lyses has been performed. Other rare differential diagno- sis of salivary glands, like lipomatous pleomorphic ...
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Antigen processing and T cell priming by mouse dendritic cells
... tissue dendritic cells present the processed antigen to T cells in lymphoid organs(Guery et al, ...not dendritic cells. To investigate whether B cells or dendritic cells were presenting the cryptic ...
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Investigations of the functional states of dendritic cells under different conditioned microenvironments by Fourier transformed infrared spectroscopy
... were significantly lower than those of DCs ( * P < 0.05) and there were no difference among DCs + HUVEC, DCs + HC and DCs ( P > 0.05), suggesting that the gene transcription states of DCs were specifically ...
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Vaccination with autologous dendritic cells loaded with autologous tumor lysate or homogenate combined with immunomodulating radiotherapy and/or preleukapheresis IFN α in patients with metastatic melanoma: a randomised “proof of principle” phase II study
... DC: Dendritic cells; DCR: Disease control rate; DFS: Disease free survival; DM: Ministerial Decree; DTH: Delayed type hypersensitivity; ECOG: (Eastern Cooperative Oncology Group, ECOG Scale) Performance status; ...
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Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells
... helper cell and deleterious IgE mediated immune ...mainly dendritic cells (DCs), leading to Th2 polarization, switch- ing to IgE production by B cells, culminating in mast cell sensitization and ...
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Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice
... altering dendritic cell function ...alters dendritic cell function and reduces Th17 cell genera- tion in SKG mice and we examined the cell surface molecules on conventional ...
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Schnorfeil, Frauke Marie (2011): MicroRNAs regulate Dendritic Cell Development and Function. Dissertation, LMU München: Medizinische Fakultät
... Binding of cytokines to their cognate cellular receptors results in downstream signaling and the activation of transcription factors. On the one hand, global DC development requires tran- scription factors that are ...
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