Dendritic cells and T cell Priming
Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naïve T-cell priming
... Dendritic cells were remarkably resistant against radiation-induced apoptosis, showed limited changes in surface phenotype, and mostly maintained their endocytic, phagocytic and migratory ...naı¨ve ...
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Antigen processing and T cell priming by mouse dendritic cells
... one cell type but not another has to be confirmed as being differently expressed by Northern blot, followed by cloning and sequencing of the ...BALB/c dendritic cells ...control cells of one ...
216
Nicotine Protects Dendritic Cells from Apoptosis and Support DCs-dependent CD4+ T-cell Priming in vitro
... + T-cells Priming Dendritic cells are antigen-presenting cells that act as messengers between the innate and adaptive immune ...of dendritic cells. However, the ...
11
Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells
... consequence, T cell and B cell responses fail to develop ...with T cells, despite presenting normal levels of peptide/MHC on their ...of T cells to fully interact with DCs ...
8
Dendritic cell migration to draining lymph node and T-cell priming to Bacille Calmette-Guérin
... arm. Cells of innate immunity include phagocytes such as macrophages, dendritic cells (DCs) and neutrophils, and innate lymphoid cells such as natural killer ...immune cells use ...
52
Effective Priming of Herpes Simplex Virus-Specific CD8+ T Cells In Vivo Does Not Require Infected Dendritic Cells
... the priming lymphoid organ ...⫹ T cell ...⫹ T cell responses, these findings argue that cross-presentation by DC in vivo is sufficient to induce effector differentiation of virus-specific ...
13
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
... instructing T cell activation, the IS transmits intracellular signals that direct DC function 3 ...cognate T cells 4 ...and T cell clonal expansion 7 ...the T cell ...
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Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
... instructing T cell activation, the IS transmits intracellular signals that direct DC function 3 ...cognate T cells 4 ...and T cell clonal expansion 7 ...the T cell ...
17
Dendritic Cell Migration Limits the Duration of CD8+ T-Cell Priming to Peripheral Viral Antigen
... ⴙ T cells (T CD8 ⴙ ) play a crucial role in immunity to ...Antiviral T CD8 ⴙ are initially activated by recognition of major histocompatibility complex (MHC) class I-peptide complexes on the ...
9
Plasmacytoid dendritic cells induce NK cell–dependent, tumor antigen–specific T cell cross priming and tumor regression in mice
... + T cell response induced by activated pDC injection was directed against multiple tumor-associated antigens, as we detected relatively robust CTL responses not only against a neo-antigen, OVA, but also ...
12
Abnormal Priming of CD4+ T Cells by Dendritic Cells Expressing Hepatitis C Virus Core and E1 Proteins
... infected dendritic cells (DC) might impair their antigen-presenting function, leading to a defective anti-HCV T-cell ...these cells (DC-CE1) were used to stimulate T ...gous ...
9
Transcriptional priming of intrathymic precursors for dendritic cell development
... Therefore, collaboration between Spi-B and Notch factors might be involved in pDC maturation within the thymus. We also investigated the expression of the E proteins HEBCan and HEBAlt in thymic DCs. Although the impact ...
13
Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells
... to T-cell ...impaired T-cell responses, we primed naïve T cells with mature monocyte-derived dendritic cells (MDDCs) pulsed with HIV-1 in ...naïve T ...
12
Cross priming of cyclin B1, MUC 1 and survivin specific CD8+T cells by dendritic cells loaded with killed allogeneic breast cancer cells
... cific T cells, which required an additional boost with MUC-1 peptide pulsed ...precursor T cells with these ...cancer cells will depend on the nature of these antigens or the form in ...
9
Systemic Toll-Like Receptor Ligation and Selective Killing of Dendritic Cell Subsets Fail To Dissect Priming Pathways for Anti-Vaccinia Virus CD8+ T Cells
... dissect priming mechanisms for antiviral CD8 ⫹ T cells in mice is far more complicated than has been ...direct priming by VACV where antigen was ...virus-infected cells was partly ...
9
Alteration of T cell immunity by lentiviral transduction of human monocyte derived dendritic cells
... + T cells from healthy donors' blood and co-cultured the T cells with allogeneic monocyte-derived DCs treated with TNFα and LPS to induce maturation, as illustrated in ...co-cultured T ...
12
β2 integrins are required for skin homing of primed T cells but not for priming naive T cells
... for T cell activation. To elucidate the role of β 2 integrins in T cell–mediated immune responses, allergic con- tact dermatitis (ACD), irritant dermatitis, and delayed-type hypersensitivity ...
11
Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells
... memory T cells cross-reactive to allogeneic MHC are able to disrupt strategies administered to recipients to induce allograft tolerance (30, 38, 39), it had remained unclear if such endogenous memory CD8 + ...
19
The instructive role of dendritic cells on T cell responses
... naïve T cells specific for a given antigen makes competition among responding cells ...responding cells proliferate, competition for sustained TCR stimulation will increase, particularly among ...
6
Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation
... of T cell activation is ...immune cells such as monocytes, dendritic cells, eosinophils and mast ...on T cell activation and also indirect effects through their influence ...
6