devil facial tumour
Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease
... Tasmanian devil (Sarcophilus harrisii), the largest extant carnivorous marsupial and endemic to Tasmania, is at the verge of extinction due to the emergence of a transmissible cancer known as devil ...
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The ecology and epidemiology of devil facial tumour disease
... venereal tumour (Murchison 2009; Belov 2010) a process which led to this tumour becoming the ultimate parasite – highly contagious but not ...canine tumour, the devil’s tumour is still young, ...
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Identification of candidate genes for devil facial tumour disease tumourigenesis
... chromosome-level devil reference genome to devil facial tumour genomes would provide details of structural mutations at the base pair level and could be particularly powerful if combined with ...
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Tasman PCR: A genetic diagnostic assay for Tasmanian devil facial tumour diseases
... Tasmanian devils have spawned two transmissible cancer clones, known as devil facial tumour 1 (DFT1) and devil facial tumour 2 (DFT2). DFT1 and DFT2 are transmitted between ...
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Biomarker discovery for pre clinical diagnosis of Tasmanian devil facial tumour disease
... As discussed in the introduction (see section 1.2), there are numerous well established instrumentation and methods that are suitable to study metabolomics based on NMR or MS detection [25, 102]. Mass spectrometry is a ...
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Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells
... Tasmanian devil faces extinction due to devil facial tumour disease (DFTD), a highly transmittable clonal form of cancer without available ...
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Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells
... Tasmanian devil faces extinction due to devil facial tumour disease (DFTD), a highly transmittable clonal form of cancer without available ...
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Spatial analysis of Tasmanian Devil facial tumour disease
... Tasmanian devil (Sarcophilus harrisii) is the world’s largest surviving carnivorous marsupial, and is only found in ...population. Devil Facial Tumour Disease (referred to as DFTD) has been ...
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Global DNA Methylation patterns on marsupial and devil facial tumour chromosomes
... Tasmanian devil (Sarcophilus harrisii) is an inter- esting species in which to study methylation patterns on ...Secondly, devil chromosomes display a remarkable telo- mere length dimorphism where one ...
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ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)
... Tasmanian devil archival slides submitted to the Animal Health Laboratory, DPIPWE, revealed a single case in 1997 that was consistent with DFT1 [8, ...the tumour to be a transmissible allograft being ...
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Manipulating the immune response of Tasmanian Devils to target Devil Facial Tumour Disease
... the tumour cells, provide two potential directions for immunotherapy: adoptive cell transfer or therapeutic ...Tasmanian devil with ...the tumour was completely ...Tasmanian devil that had ...
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Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils
... LHS tumour, four weeks after immunotherapy, revealed moderate numbers of MHC-II + cells towards the tumour periphery and a few within the ...Neither tumour (LHS and RHS) was palpable 70 days after ...
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Immune recognition of devil facial tumour disease by the Tasmanian devil
... Tasmanian devils with DFTD had higher levels of both IgM and IgG which correlates with results from a previous study that showed devils with DFTD had higher globulin levels than healthy devils (Peck et al., 2016). ...
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The newly arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer
... The classical MHC class I alleles expressed by DFT2 cells should play a role in any host immune response against the tumour. To assess the MHC class I alleles expressed by DFT2 cells we ampli- fied, cloned and ...
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Toll like receptors in the endangered Tasmanian devil and devil facial tumour disease
... with tumour-promoting inflammation and poor prognosis (Yu et ...to tumour development, suggesting a key role for TLR signalling in immunosurveillance (Yusuf et ...of tumour cell apoptosis, autophagy ...
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Devil Facial Tumour Disease: In vivo studies in mice
... Early attempts at cancer vaccines depended on tumour antigen presentation but failed to recognise the importance of co-stimulatory signals required to elicit a CTL response. This is a critical requirement of the ...
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Untangling the model muddle: Empirical tumour growth in Tasmanian devil facial tumour disease
... repeat tumour measurements were recorded between 2006 and 2015 (diploid n = 32, tetraploid n = 10, unknown ploidy n = 45, dermal n = 31, mucosal n = 44, unknown location n = ...which tumour ploidy was ...
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Spatial analysis of Tasmanian Devil facial tumour disease
... LEGEND Dry Eucalypt Forest and Woodland Highland treeless vegetation WDL Eucalyptus delegatensis forest over Leptospermum NLE Leptospermum forest DAC Eucalyptus amygdalina coastal forest[r] ...
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Population and disease modelling in the Tasmanian devil
... large facial tumours were reported at Mt William National Park in the north east of Tasmania in 1996 (Hawkins et ...Tasmanian devil population, and a research effort to gather data on the mysterious disease ...
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Redefining the role of tumour necrosis factor in macrophage differentiation and effector function in bacterial and tumour defences
... Macrophage phagocytosis is a critical function in defence against pathogens. The role of TNF in macrophage phagocytosis was investigated with the tumour cells causing Devil Facial Tumour ...
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