Dickkopf-1
Dickkopf-1 and Amphiregulin as Novel Biomarkers and Potential Therapeutic Targets in Hepatocellular Carcinoma Dickkopf-1 and Amphiregulin in HCC
... Background: Hepatocellular carcinoma (HCC) is a highly fatal tumor which represents a major health problem worldwide. Due to asymptomatic nature of HCC, most patients present with the progressive stage of disease, so, ...
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<p>The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer</p>
... to Dickkopf gene family which comprises of 5 evolutionarily conserved members, DKK1, DKK2, DKK3, DKK4, and a unique DKK3-related protein, ...DKKL1. 1 The DKK gene family was fi rst identi fi ed and named by ...
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Serum Dickkopf-1 expression level positively correlates with a poor prognosis in breast cancer
... Dickkopf-1 (DKK-1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway [6]. DKK-1 binds to lipoprotein receptor-related protein-5/6 (LRP5/6) and blocks ...
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Circulating levels of Dickkopf 1, Osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole body bone mineral density in older adults
... of Dickkopf-1, Osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older ...
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Serum dickkopf-1 as a biomarker in screening gastrointestinal cancers: a systematic review and meta-analysis
... A systematic literature search of PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, and WANFANG databases was conducted to identify the related studies published before May 1, 2015, which ...
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Serum dickkopf-1 is a novel serological biomarker for the diagnosis and prognosis of pancreatic cancer
... Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt/β-catenin signaling that is required for embryonic head formation in vertebrate development [5-7]. DKK1 regulates Wnt signaling pathway by binding to ...
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Dickkopf 1 (Dkk 1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients
... expression. Dickkopf-1 (Dkk-1) is a secreted protein that has been defined as a direct inhibitor of Wnt/ b-catenin signaling by interacting with the LRP5/6 co- receptors of frizzled ...
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Differential expression of beta-catenin and dickkopf-1 in the third trimester placentas from normal and preeclamptic pregnancies: a comparative study
... group. Dickkopf-1 (DKK1) is a secreted glycoprotein that can antagonize the canonical Wnt signaling pathway, and our study indicated that the expression of DKK1 was in- creased in the placenta with severe ...
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Dickkopf-1 expression is associated with tumorigenity and lymphatic metastasis in human hilar cholangiocarcinoma
... Dickkopf-1 (DKK1) is involved in tumorigenesis and the invasion of several tumors. However, its biological function in human hilar cholangiocarcinoma (HCCA) has not yet been documented. This study was ...
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DICKKOPF-1 SERUM LEVELS IN SAUDI BOYS WITH CEREBRAL PALSY AND CORRELATIONS WITH BODY MASS INDEX AND BONE TURNOVER MARKERS
... Cerebral palsy (CP) is a common disorder in children. Dickkopf-1 (Dkk1) inhibits the canonical Wnt signaling pathway. The study aimed to assess the serum levels of Dkk1 in boys with CP and to evaluate its ...
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Original Article Regulation of exogenous P53 combined with Dickkopf-1 on human osteosarcoma MG-63 cells
... and Dickkopf-1 and to explore its possible mechanisms in order to provide the refer- ence for clinical treatment of ...and Dickkopf-1 were used separately or jointly to act on MG-63 ...and ...
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Dickkopf 1 Is Associated with Periarticular Bone Loss in Patients with Rheumatoid Arthritis*
... pathways, Dickkopf-1 (DKK1) and hepatocyte growth factor (HGF), respectively, inhibit osteoblast differentia- tion and are associated with bone destruction in RA and multiple myeloma ...
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Elevated expression of Dickkopf-1 increases the sensitivity of human glioma cell line SHG44 to BCNU
... Dickkopf-1(DKK-1) gene was first discovered in 1998 as a head formation inducer and an antagonist of Wnt signaling pathway [1]. In normal tissues of human body, DKK-1 mRNA was highly ...
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Serum Dickkopf 1 signaling and calcium deposition in aortic valve are significantly related to the presence of concomitant coronary atherosclerosis in patients with symptomatic calcified aortic stenosis
... (Wnt)/ Dickkopf-1 (Dkk-1) signaling have been linked to the de- velopment of atherosclerosis and might be along the causal pathway in regulation of valvular calcification in ...
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A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model
... The role of Wnt signaling in the pathogenesis of osteosarcoma is unclear. Although Wnt signaling has been implicated as a driver of osteoblast differentiation, other work has suggested that Wnt signaling may also drive ...
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Analysis of the expression profile of Dickkopf-1 gene in human glioma and the association with tumor malignancy
... (Figure 1). In glioblastoma cell lines UW-28, SKI-N2, and SF295, DKK-1 mRNA expression was relatively lower as compared with other glioblastoma ...(Table 1). U251 cells have the highest levels of ...
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Original Article Dickkopf-1 induces pancreatic carcinogenesis through upregulation of c-Myc and cyclin D1
... Cells were harvested 48 hours after transfec- tion, as described above. Cells were resus- pended in 150 μL of cell protein lysis buffer (RIPA buffer to PMSF ratio of 100:1). Total pro- tein was quantified using ...
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Bmp, Fgf and Wnt signalling in programmed cell death and chondrogenesis during vertebrate limb development: the role of Dickkopf 1
... During chick limb development, Fgf-10 induces the expression of Wnt-3a in the AER (Kawakami et al., 2001). The induction of Dkk-1 by Fgf might thus be mediated by Wnt ligands, in particular Wnt-3a, which is a ...
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Dysregulation of the WNT Signaling Pathway Through Methylation of Wnt Inhibitory Factor 1 and Dickkopf-1 Genes among AML Patients at the Time of Diagnosis
... for 1 minute and 95 Cº for 3 minutes followed by 35 cycles including 99 Cº for 10 seconds, 95 Cº for 30 seconds, 58 Cº for 30 seconds (WIF1- UM Primer), 62 Cº for 30 seconds (WIF1 and DKK-1-M Primer) and 70 ...
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Combined detection of dickkopf-1 subtype classification autoantibodies as biomarkers for the diagnosis and prognosis of non-small cell lung cancer
... for 1 h at 37 ° C and then 5% skim milk was ...at 1:100 in 5% skim milk and 100 μ L 5% skim milk were added to the negative control wells and were then incubated overnight at 4 ° ...
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