Discovery and current understandings RNA interference
The Fascinating World of RNA Interference
... small RNA family that are recognized as critical regulatory species across the ...The discovery of these species of small RNAs has allowed us to understand better the usage of genome and the number of genes ...
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RNA Interference: Past, Present and Future
... Abstract RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded ...a RNA-induced silencing complex (RISC) that targets and cleaves mRNA complementary to the ...our ...
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RNA Interference, Mechanisms and Proteins Involved in
... breakthrough discovery of small reg- ulatory RNAs and their multiple functions in gene regulation has heralded a fascinating new field in ...winning discovery of RNA interference (RNAi) in ...
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Enhancement of RNA Interference Effect in P19 EC Cells by an RNA-dependent RNA Polymerase
... The current studies based on evidences from ...enzyme, RNA-dependent RNA polymerase (RdRP), and is believed to be the reason behind the amplification effect seen in systemic silencing [15, ...
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RNA Interference: a Promising Therapy for Gastric Cancer
... Nowadays the main use of this technology is related to the investigation of new drugs and therapeutic targets in experimental trials. In the short term, we may probably be able to follow the steps to the development and ...
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Inhibition of Monkeypox virus replication by RNA interference
... The use of RNAi pathway as a new approach in antiviral drug discovery is particularly promising because viruses have relatively small genomes with a limited number of targetable genes. Furthermore, genetic ...
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RNA Interference in Fungi: Pathways, Functions, and Applications
... eukaryotes. Current research recognizes seven phyla and one subkingdom that consists of two phyla, Ascomycota and Basidi- ...on current fungal taxonomy, yeasts and fila- mentous fungi do not form a ...
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RNA Interference in Protozoan Parasites: Achievements and Challenges
... Although the original T. brucei study showed that dsRNA transfection resulted in significant downregulation of target mRNA levels, it was disappointing to discover that, contrary to the results of a C. elegans study ...
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An Insight To RNA Interference Based Gene Silencing
... exploit RNA interference in ...of RNA interference, especially the potential for "off- target" effects in which a gene with a coincidentally similar sequence to the targeted gene is ...
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RNA motif discovery: a computational overview
... Hence RNA secondary structure prediction is one of the most well studied problems in computational RNA ...reliable RNA structure prediction approaches as it exploits information of multiple related ...
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Betanodavirus B2 Is an RNA Interference Antagonist That Facilitates Intracellular Viral RNA Accumulation
... 5C, RNA1 synthesis commenced within 3 h postinfection in both GGNNV- and rGGNNV-infected cells, with RNA1 con- tinuing to accumulate over the 44-h sampling period. The total amplification of RNA1 by GGNNV and rGGNNV ...
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ESF EMBO Symposium: Antiviral Applications of RNA Interference
... Joost Haasnoot (University of Amsterdam) also presented data on the interplay of cellular miRNAs and HIV-1 repli- cation. miRNA expression profiles were studied in HIV-1 infected T-cells using a quantitative RT-PCR ...
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Understanding the molecular mechanisms of RNA interference in Caenorhabditis elegans
... Ph.D.) RNA interference (RNAi) is a recently discovered phenomenon in which double-stranded RNA (dsRNA) silences endogenous gene expression in a sequence-specific ...its discovery, the use of ...
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RNA interference- a novel approach for plant disease management
... on current molecular biology and biotechnologi- cal methods are exploited and their utilization by intro- gression, pyramiding, and development of transgenics have been well understood (Sanghera et ...
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Current multidisciplinary definitions and understandings of ‘paedophilia’
... This current article has illustrated that the construction of paedophilia/CSA is not simply demonstrated through examining clinical and legal perspectives but is entwined with a number of other far ranging issues ...
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Suppression of RNA Interference by Adenovirus Virus-Associated RNA
... However, if suppression of RNAi is a general strategy used by mammalian viruses, therapeutic intervention of virus infec- tions by siRNA treatment needs to take this suppressive mech- anism into account. Also, the ...
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Engineering Ligand Control of RNA Interference
... mechanism, RNA interference (RNAi), provided the motivation to pursue the design of riboswitches that exploit this powerful mechanism of control (Sahu et al, 2007; Scherer and Rossi, ...
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Inhibition of Gammaherpesvirus Replication by RNA Interference
... To further confirm that inhibiting ORF 45 and Rta expres- sion by specific siRNAs diminishes gammaherpesvirus replica- tion during de novo virus infection, 293T cells were transfected with RNA duplexes and then ...
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RNA Interference (RNAi) Screening in Drosophila
... decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided degradation of messenger RNA transcripts, has had an important impact on identifying and characterizing gene ...
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A Caenorhabditis elegans RNA-Directed RNA Polymerase in Sperm Development and Endogenous RNA Interference
... foreign RNA and transposable elements, siRNA functions in endogenous gene regulation have remained ...as RNA- directed RNA polymerases ...small RNA sequencing, we identified a population of ...
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