Distinct cyclin E-CDK2 dependent phosphorylation of MCM2
Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... these phosphorylation events have been established for the first three sites but not the ...that phosphorylation of S331 could lead to increased protein ...
131
Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
... ABSTRACT Cyclin E/Cdk2 kinase activity is frequently deregulated in human cancers, resulting in impaired ...that cyclin E/Cdk2 phosphorylates and stabilizes the pro-survival ...
14
A Screen for Modifiers of Cyclin E Function in Drosophila melanogaster Identifies Cdk2 Mutations, Revealing the Insignificance of Putative Phosphorylation Sites in Cdk2
... phosphoryla- Distinct modes of cyclin E/cdc2c kinase regulation and S phase tion of the retinoblastoma protein by G1/S cyclin-dependent control in mitotic and endoreduplication cycles ...
12
Identifying substrates of CDK2: cyclin A.
... a cyclin as the bait protein, then any potentially interesting clones would be masked by cyclin clones that would predominantly be identified, or the important enzyme-substrate interactions may be ...
189
INHIBITION STUDIES OF TERPENE BASED NATURAL PRODUCTS WITH CYCLIN DEPENDENT KINASE 4 (CDK4 MIMIC CDK2)
... The cyclin-dependent protein kinases (CDKs) are regulators of the timing and coordination of eukaryotic cell cycle ...with phosphorylation by CDK- activating kinase on a specific threonine ...The ...
8
Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
... lacking cyclin D1 expression and conse- quently lacking CDK4 activation still developed mammary tumours induced by MYC activation [51], strongly arguing that the requirement for CDK4 activity in MYC-induced ...
14
Drosophila double parked is sufficient to induce re replication during development and is regulated by cyclin E/CDK2
... that phosphorylation and stability of Dup depends on cyclin E/CDK2 ...with CDK2 protein and activity in ...other CDK2-dependent mechanisms for ...that ...
12
Genetic Analysis of the Relationship Between Activation Loop Phosphorylation and Cyclin Binding in the Activation of the Saccharomyces cerevisiae Cdc28p Cyclin-Dependent Kinase
... activation: cyclin binding and activa- tional changes in structure upon phosphorylation of tion loop ...in- cyclin-bound Cdk2 result in a very large increase in volves the refolding of the ...
11
Cyclin dependent kinases
... in Cdk2; EMBL:AK291941) to the APE motif (E172 in Cdk2) and includes the phosphorylation- sensitive (T160 in Cdk2) residue in the so-called T-loop (Figure ...the cyclin-free monomeric ...
10
Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin dependent kinase
... Despite its simplicity, spatial clustering represents a poten- tially powerful new method for computationally identifying a subset of CDK targets. Unlike current methods, which predict individual phosphorylation ...
14
Interactions between Human Cytomegalovirus IE1-72 and Cellular p107: Functional Domains and Mechanisms of Up-Regulation of Cyclin E/cdk2 Kinase Activity
... the phosphorylation of pocket proteins by G 1 cyclin/cdk regu- lated their interaction with E2Fs and the expression of genes controlled by these transcription ...of cyclin E/cdk2 ...
11
Inhibitors of cyclin-dependent kinases as cancer therapeutics.
... RB phosphorylation in tumor lysates (Fry, et ...which cyclin D-dependent CDKs are deregulated (Baughn, et ...of cyclin D1 and RB, and low levels of the CDK-regulator CDKN2A ...estrogen-induced ...
88
Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... involvement of other mechanisms than CDK2 inhibition in the anticancer activity of AT7519 in neuroblastoma cells. In addition, high dose treatment with AT7519 elicited striking down- regulation of MYCN protein ...
22
Investigation of the role of cyclin dependent kinases in neuronal apoptosis
... division, arrest growth to repair cellular damage, or undergo apoptosis if the damage is too severe to be repaired or if the cell is incapable of repairing the DNA (Lundberg and Weinberg, 1999). In fission yeast, Cdc2 is ...
204
Cyclin-Dependent Kinase 1/Cyclin B1 Phosphorylates Varicella-Zoster Virus IE62 and Is Incorporated into Virions
... no phosphorylation of amino acids (aa) 823 to 1238 or the unconjugated MBP alone, which was expected due to the ab- sence of consensus sequences for CDK ...
10
Role of MCM2–7 protein phosphorylation in human cancer cells
... multisite phosphorylation, an important change that promotes subsequent assembly of other replisome ...members. Phosphorylation is crucial for the regulation of MCM activity and ...these ...
8
Mitotic p21 Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation
... In the present work we show that S130 of p21 is phosphorylated by Cdk1/cyclin B1 during mitosis, which reduces p21’s stability and binding affinity to Cdk1/cyclin B1. Interfering with this ...
14
cdc2/Cyclin B1-Dependent Phosphorylation of EBNA2 at Ser243 Regulates Its Function in Mitosis
... that phosphorylation at Ser243 by EBV PK might also have a general suppressive effect on EBNA2- responsive ...Ser243 phosphorylation only happens in mi- tosis, whereas introducing EBV PK into ...
6
Phosphorylation of HIV 1 Tat by CDK2 in HIV 1 transcription
... potential phosphorylation site, whereas Peak II contains peptides with Serine 16 as a potential phosphorylation ...by CDK2 and that this phosphorylation might take place at Ser 16 or Ser 46 ...
21
Functional Interaction between the Bovine Papillomavirus Virus Type 1 Replicative Helicase E1 and Cyclin E-Cdk2
... the cyclin E-Cdk2 kinase is most likely a cellular partner of the BPV replicative helicase ...E1, cyclin E, and Cdk2 added to Xenopus egg extracts through translation of their ...
8