DNA damage checkpoint protein 1
A Werner syndrome protein homolog affects C elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint
... to human WRN; it has therefore been named as wrn-1 in WormBase (http://www.wormbase.org; Fig. 1). As the yk41c3 EST clone was shorter than the predicted ORF at its 5′-end, a 5′-end cDNA clone was amplified ...
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New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment
... immune checkpoint inhibitors (ICIs) have been introduced for mUBC as second-line treat- ment of post platinum-based chemotherapy or for cisplatin-inelegibile ...death protein 1 (PD-1), ...
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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
... 53BP1-RAD9 protein proximity ligation assays, U2OS or RPE1 cells were seeded at a density of ...mL 1 in PBS) solution and fix- ated with methanol for 20 min at ...another 1 hr at 37˚C followed by ...
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Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
... Upon DNA damage caused by chemotherapy, checkpoints respond to DNA damage by arresting the cell cycle to pro- vide time for DNA ...repair. Checkpoint signalling following ...
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The Saccharomyces cerevisiae F-Box Protein Dia2 Is a Mediator of S-Phase Checkpoint Recovery from DNA Damage
... the checkpoint recovery pathway among players identified to have a role in the path- ...S-phase checkpoint re- covery (O’Neill et ...(Figure 1, C and D). We then examined checkpoint recovery ...
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Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death
... Figure 2 Concentration-dependent protection of irradi- ated oocytes by CHK2iII. (A) Schematic of CHK2iII treat- ment regimen, beginning with placing explanted 5 dpp ovaries into culture. Blue droplets denote times at ...
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Overlapping Roles of the Spindle Assembly and DNA Damage Checkpoints in the Cell-Cycle Response to Altered Chromosomes in Saccharomyces cerevisiae
... of checkpoint pathways involved in responding to stalled replication and DNA ...sensitive DNA-responsive checkpoint. The response to DNA-damaging agents such as MMS and ionizing ...
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Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans
... of DNA damage repair has attracted more attention to the fi eld in recent ...in DNA damage repair, and only a few studies have focused on the roles of histone demethylases in germline ...(FA) ...
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The conservation of genotoxic stress-induced morphological changes in yeasts
... the DNA integrity checkpoints are the highly conserved ...–related protein kinases Tel1 and Mec1 (Figure 1), the mammalian homologs of ATM and ATR [5, ...When DNA damage is detected by ...
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Regulation of DNA replication by the S-phase DNA damage checkpoint
... bulk DNA synthesis measured by radiolabel incorpora- tion is increased in cells exposed to caffeine which inhibits both ATM and ATR prior to S-phase ...Chk1 protein levels causes elevated origin firing ...
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checkpoint following DNA damage by doxorubicin during transient mitotic arrest
... but DNA damage can cause genomic instability by inducing mutations within chromosomal ...against DNA damage. During the checkpoint process, cells recognize DNA damage and ...
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Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants
... the DNA damage sensitivity of rad53D cells is partially suppressed by loss of the Rpd3L com- plex (Figure 1 and Figure ...in checkpoint-deficient ...new protein synthesis is not required ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... as DNA damage-induced breaks, repair mechanisms like non-homologous end joining (NHEJ) are able to join any two dysfunctional chromosomal ends and lead to chromosomal fusions by recombination ...active ...
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Working hard for recovery: mitotic kinases in the DNA damage checkpoint
... kinase 1 (Plk1) is a well- studied mitotic kinase whose inactivation leads to multi- ple mitotic defects and cell ...and protein interaction ...a protein phosphatase complex named ...
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The DNA Damage Response and Checkpoint Adaptation in Saccharomyces cerevisiae: Distinct Roles for the Replication Protein A2 (Rfa2) N-Terminus
... to DNA damage, two general but fundamental processes occur in the cell: (1) a DNA lesion is recognized and repaired, and (2) concomitantly, the cell halts the cell cycle to provide a window of ...
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Reconstitution of a human ATR-mediated DNA damage checkpoint prespone [sic]
... ATR-mediated checkpoint system in ...the checkpoint signaling reaction may be reestablished by including DNA in the ...of DNA with and without ...of DNA to this reaction resulted in a ...
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RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival
... altered DNA damage response commonly seen in cancer cells after RBX1 silencing can also be observed in RBX1- p27 double null embryos and if so, its contribution to the embryonic lethality in the later ...
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Possible attenuation of the G2 DNA damage cell cycle checkpoint in HeLa cells by extremely low frequency (ELF) electromagnetic fields
... genetic damage [7] and in vitro assays of muta- genicity have been negative ...the damage is repaired during the "time-out" response to the so-called DNA damage cell cycle check- ...
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DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
... of checkpoint signaling, including the blocks to mitosis and further DNA replication, activation of ATR kinase, and physical association of Rad17 with chroma- ...the DNA duplex before replication may ...
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Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword
... to DNA damage ATM and ATR not only stop cell cycle progression but also initiate DNA repair by phosphorylating several other ...If damage cannot be repaired, the cell destiny might be death or ...
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