DNA damage response
PHD3 dependent hydroxylation of HCLK2 promotes the DNA damage response
... PHD3 interacts with HCLK2. We used MALDI/TOF mass spec- trometry (MS) as an inductive and unbiased method of identi- fying PHD3-associated proteins in HeLa cells stably transfected with Flag-PHD3. Using this approach, we ...
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Activation of the DNA Damage Response Is a Conserved Function of HIV 1 and HIV 2 Vpr That Is Independent of SLX4 Recruitment
... the DNA damage re- sponse by Vpr. While we found activation of the DNA damage response to be conserved, our results suggest that SLX4 recruit- ment by Vpr is not conserved by HIV-1, ...
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Radiation therapy induces the DNA damage response in peripheral blood.
... kinase-dependent DNA damage response in the peripheral blood is unprecedented and promotes the use of ATM serine-1981 phosphorylation as a predictive biomarker for DNA damaging modalities and ...
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PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
... and DNA damage response (7, 8), it remains unknown how this oxidoreductase PIG3 functions in DNA damage sig- ...the DNA damage response induced by ionizing ...
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The Smc complexes in DNA damage response
... mediate DNA repair are not ...their DNA repair functions are separ- able from their major functions in sister-chromatid cohesion and chromosome ...the DNA repair func- tions of the Smc complexes are ...
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Investigation of Novel Functions of KICSTOR Components in the DNA Damage Response
... in response to environmental cues and is a member of the phosphoinositide 3-kinase (PI3K)-related kinase ...inhibit DNA damage responses in non-small cell lung cancer (NSCLC) cell lines suggesting ...
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Characterisation of CIP29:a potential target of the eukaryotic DNA damage response
... The DNA damage response (DDR) is a global signalling network dedicated to maintaining genome integrity by identifying DNA damage, eliciting cell cycle arrest, activating DNA ...
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Singular v Dual inhibition of SNF2L and its isoform, SNF2LT, have similar effects on DNA Damage but opposite effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis
... along DNA during the remodeling process and binding to histone, in which the binding may be important for nucleosome ...in DNA damage, the DNA damage response, cell cycle arrest ...
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Sak and its potential role in the DNA damage response.
... in DNA damage ...of DNA damage, this protein is classically believed to become activated by ATM in response to ionizing radiation (for review, see Bartek and Lukas, ...
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A role of SUMOylation in proteostasis, centromere integrity and the DNA damage response
... in response to ultraviolet (UV)- induced or ionizing radiation (IR)-induced DNA damage (chapter ...signalling, DNA replication or are components of the proteasome (Figure ...(CCAN), DNA ...
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Functions of DNA Damage Response Factors in Lymphocyte Development and Transformation
... between DNA damage response factors likely depend on the cellular ...how DNA damage and repair factors coordinately regulate V(D)J recombination, lymphocyte development and neoplastic ...
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Scorpins in the DNA Damage Response
... The DNA damage response (DDR) is an attractive target for anti-cancer treatments due to the increased genotoxic stress that malignant cells experience[1] ...the damage are limited to a handful ...
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Physical and in silico approaches identify DNA PK in a Tax DNA damage response interactome
... and DNA-PK was selected, through our functional clustering approach, whereas other equally critical damage response proteins were ...the DNA damage-response arena equal to ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... programmed response triggered in normal cells experiencing various types of stimuli, including telomere erosion [1-3], DNA damage [4], induction of oncogenes [5] and oxidative stress ...in ...
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The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF kappaB activation
... the DNA damage response (DDR) is also known to result in the activation of the NF-κB signaling pathway, a phenomenon known as nucleus to cytoplasm or “inside-out” NF-κB signaling [26–28], which is ...
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Development and validation of an assay for the characterization of the DNA damage response to damage caused by superfund chemicals
... UV damage, abasic sites and TLS through chemically damaged bases (reviewed by Prakash et ...1) DNA-Cr-X ternary adducts are formed during the S-phase of the cell cycle; 2) replication forks encounter these ...
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Saccharomyces cerevisiae Dap1p, a Novel DNA Damage Response Protein Related to the Mammalian Membrane-Associated Progesterone Receptor
... (37, 14). A rat homologue of MAPR, called 25-Dx, was cloned at the same time in a phage display screen for elevated tran- scripts in rat liver following treatment with 2,3,7,8-tetrachlo- rodibenzo-p-dioxin (46). ...
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Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response
... differential response to DNA insults under hyperglycemia in the mother and the fetus’s ...mtDNA damage seen in blood cells from GDM and DM2 mothers were not found in the blood cells of their ...of ...
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ATP-dependent chromatin remodeling in the DNA-damage response
... Different members of the CHD family of chromatin remodelers are involved in regulating DSB repair in chromatin. It has been shown that CHD3 is dispersed from DSBs in heterochromatin via a mechanism invol- ving KAP-1 ...
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Structural and Functional Characterization of Deinococcal DNA Damage Response A (DdrA)
... D. radiodurans is remarkably resistant to mitomycin C, a common chemotherapeutic agent that has been utilized for the treatment of a wide variety of cancers (Bradner, 2001). MMC is a cross-linking agent that forms deoxy- ...
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