DNA demethylation
Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems
... for DNA repair, cell cycle regulation and adaptive mutagenesis under stress ...Y-family DNA polymerase-related domain in ImuB, and also occurs as a standalone ...a DNA-associated autoproteolytic ...
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Association study between SNP rs150689919 in the DNA demethylation gene, TET1, and Parkinson’s disease in Chinese Han population
... the DNA demethylation gene, TET1, encodes the human ten-eleven translocation 1 protein, was brought to ...genomic DNA or intermediate in the process of DNA demethylation ...
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IL 4 orchestrates STAT6 mediated DNA demethylation leading to dendritic cell differentiation
... of DNA de- methylation. Conversely, very few DNA demethylation changes occur during the activation of these two cell types when exposed to LPS, which activates these cells to re- spond through TLR4 ...
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The role of thymine DNA glycosylase (TDG) and DNA demethylation in TGF beta signaling
... and demethylation occur frequently at transcriptional regulatory ...with DNA binding on some promoters (Clark et ...with DNA demethylation processes in TGFβ ...
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A replication dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells
... genome-wide DNA methylation and H3K9 dimethylation marks in a stepwise manner during migration and gonadal ...profiled DNA and histone methylation on transposable elements during PGC development, and ...
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A screening system to identify transcription factors that induce binding site-directed DNA demethylation
... both DNA methylation and ...as DNA-demethylating TFs and that we found no TFs involved in DNA ...of DNA demethylation, although the selection of these 15 TFs was manual curation based ...
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Precision DNA demethylation ameliorates disease in lupus-prone mice
... enhanced DNA demethylation in either CD4 or CD8 T cells is clinically beneficial in mice with established disease, despite the fact that global demethylation orchestrates the development of ...
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PRDM14 promotes active DNA demethylation through the Ten eleven translocation (TET) mediated base excision repair pathway in embryonic stem cells
... DNA demethylation can occur through passive or active mechanisms. Passive DNA demethylation is triggered by inhibition of the maintenance activity of DNA methyltransferases during de ...
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CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR 29b in peripheral blood mononuclear cells in systemic lupus erythematosus
... induce DNA demeth- ylation via various ways ...induce DNA demethylation in SLE and miR-29b expression was inversely correlated with DNA methylation in ...inhibit DNA ...
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Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation
... similar DNA methylation signature compared to primary muscle stem cells and, interestingly, a stepwise DNA demethylation was identified ...similar demethylation time course, reaching a total ...
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A permissive chromatin structure is adopted prior to site-specific DNA demethylation of developmentally expressed genes involved in macronuclear differentiation
... this demethylation event, the old macronucleus disintegrates and the spe- cific methylation pattern is transmitted from the micro- nucleus to the vegetative macronucleus during nuclear ...
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DNA demethylation by 5-aza-2′-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences
... global demethylation of the genome, we treated the HEK 293 T cell line with a range of 5-aza- CdR ...in DNA methylation, we allowed the treated cells to recover and grow in culture for a further 30 days, ...
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CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter
... specific demethylation at targeted loci of BRCA1 gene promoter by fusing TET1 catalytic domain to the CRISPR-dCas9 ...robust demethylation of any DNA sequence when using specific ...
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Original Article Promoter DNA demethylation of Keap1 gene in diabetic cardiomyopathy
... genomic DNA isolated from biopsy samples were subjected to bisulfite conversion by EZ DNA Methylation-Direct™ kit (Zymo Research Corporation, Orange, ...ed DNA was then used for bisulfite genomic ...
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Dynamics of 5 carboxylcytosine during hepatic differentiation: potential general role for active demethylation by DNA repair in lineage specification
... from DNA during this ...active DNA demethylation governs rearrangement of the DNA methylation patterns at the transition from a progenitor to an early functional hepatocyte ...
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Epigenetic reprogramming in mouse pre implantation development and primordial germ cells
... active DNA demethylation have been reported, future genetic analyses of candidate components of these DNA-demethylation pathways are required to substantiate their proposed ...for DNA ...
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Characterizing the Role of Thymine DNA Glycosylase in Transcriptional Regulation and Cancer In Vivo
... in DNA methylation and/ or histone tails modification and is important for a variety of biological ...stable DNA mark. Recent studies has shed light on the plasticity of DNA methylation during ...
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Baumann, Valentin (2019): Identification and manipulation of chromatin barriers in transcriptional reprogramming. Dissertation, LMU München: Graduate School of Systemic Neurosciences (GSN)
... on DNA methylation as a potential barrier to gene induction, because there was a pronounced difference between responsive and unresponsive cells in DNA methylation levels at the Sox1 ...of DNA ...
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TET proteins and the control of cytosine demethylation in cancer
... cytosine demethylation and in the control of cellular differentiation and trans- ...turn, DNA demethylation. Deregulation of DNA methylation may also be achieved directly through mutations in ...
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<p>Expression Profiles of DNA Methylation and Demethylation Machinery Components in Pediatric Myelodysplastic Syndrome: Clinical Implications</p>
... the DNA demethylation machinery and they have relevant roles in cells ...in DNA demethylation, has also been shown to be an important source of mutations in human ...
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