DNA double-strand break
DNA Double Strand Break Repair and its Association with Inherited Predispositions to Breast Cancer
... deficient DNA repair processes were more common than originally believed was revealed by the identification of the genetic basis of a relatively common inherited predisposition to colorectal cancer, namely HNPCC, ...
7
The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair
... integrity, DNA replication, gene transcription, signal transduction, and immune ...(NHEJ) DNA repair and chromatin binding, including Ku80 (XRCC5), Ku70 (XRCC6), retinoblastoma-binding protein 4 (RBBP4), ...
13
Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment
... persisting DNA-DSB were detected at 6 h, after applying the combined treatment modalities as compared to radiation treatment ...their DNA- DSB breaks. Thus, the addition of HT and DNA-PKcs to ...
10
Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.
... Synthetic sensitivity of haploid 5-932 mutants to DNA damage: Our observations show that dominant-nega- tive alleles of RAD52 similarly suppressed the W and MMS sensitivi[r] ...
11
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
... Unrepaired DNA double- strand breaks (DSB) are the principal lesions that determine responses in tumours and normal tissues, following treatment with radiation and/or several cytotoxic agents ...
6
Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway
... of ER stress. As shown in Figure 1A, phospho-eIF2 α was increased in a concentration-dependent manner after OV2008 cells were treated with quercetin for 12 h, which indicated that quercetin could induce ER stress. ...
11
DNA double strand break repair enzymes function at multiple steps in retroviral infection
... host DNA in a control cell line, MRC5SV, and found one abnormal junction with a single nucleotide insertion, and seven junctions with deletions in viral DNA ends (Fig- ure ...in DNA-PKcs-deficient ...
13
Chemotherapeutic compounds targeting the DNA double strand break repair pathways: the good, the bad, and the promising
... of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic ...stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material ...
18
Tying the loose ends together in DNA double strand break repair with 53BP1
... to DNA damage ...of DNA damage ...in DNA repair in fission yeast ...multiple DNA damage sig- nals are programmed into Crb2 function, allowing it to coordinate DNA repair with cell cycle ...
13
Regulation of DNA Double-Strand Break Repair by
... Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in. 780[r] ...
28
Evidence for conservative (two-progeny) DNA double-strand break repair.
... Intramolecular double-strand break repair in the RecE pathway (in a recBC sbcA strain): As our aim is in demonstration of intramolecular recombination and, therefore, cons[r] ...
13
Original Article Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan
... of DNA double strand break, showed that its expression was significantly increased in foci of BilIN, IPNB and invasive carcinoma as well as in non-neoplastic biliary epithelial cells of the ...
10
The Relative Biologic Effectiveness versus Linear Energy Transfer Curve as a Cell Trait
... the DNA double strand break (dsb) repair pathway; and the context is cellular stress responsing to DNA damage by both external stimuli and internal redox ...of DNA twisting for ...
5
MTE1 Functions with MPH1 in Double-Strand Break Repair
... early strand exchange intermediates by the Mus81–Mms4 nuclease (Mazon and Symington ...of double-strand breaks (Luke-Glaser and Luke 2012) and promotes template switching during BIR (Stafa et ...
18
Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 Cleavage in Leishmania
... Due to the low DSBR efficiency, more than half of DSBs created by Cas9 were not repaired in Leishmania, resulting in cell death. As described above, in contrast to other organisms, Leishmania relies on the likely most ...
26
Incorporation of Large Heterologies Into Heteroduplex DNA During Double-Strand-Break Repair in Mouse Cells
... EcoRV segment (denoted M2* to distinguish it from the wild-type chromosomal sequence, M2) from the C-region. In each vector backbone, the 372-bp NsiI/NdeI fragment encompassing the SV40 early region enhancer was ...
10
The Drosophila spn-D Gene Encodes a RAD51C-Like Protein That Is Required Exclusively During Meiosis
... in double-strand DNA break (DSB) repair enzymes, such as spn-B, activate a meiotic checkpoint leading to dorsal-ventral patterning defects in the egg and an abnormal appearance of the oocyte ...
8
Strand Invasion and DNA Synthesis From the Two 3′ Ends of a Double-Strand Break in Mammalian Cells
... of DNA ends in recombination has Adair et ...free DNA ends, such as those generated of homology, suggesting strand invasion and the prim- by the reversal of a replication fork, or when a replica- ing ...
10
Capture of DNA Sequences at Double-Strand Breaks in Mammalian Chromosomes
... study double-strand break (DSB)-induced mutations in mammalian chromosomes, we transfected thymidine kinase (tk)-deficient mouse fibroblasts with a DNA substrate containing a recognition site ...
10
Coordination of DNA Ends During Double-Strand-Break Repair in Bacteriophage T4
... addition. DNA was digested with AseI alone (odd-numbered lanes) or AseI plus HaeIII (even-numbered lanes), and plasmid bands were visualized using a probe for the regions of plasmid ...
12