DNA methylation maintenance by UHRF1, the Flipping
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
... and DNA repair ...of DNA methylation marks, whereas the maintenance DNA methyltransferase Dnmt1 maintains methylation patterns on the newly syn- thesized daughter strand during ...
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Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo
... of methylation but rather the maintenance of a constant degree of hemimethylated CpG dyad patterns at various repetitive ...) methylation mechanisms to precisely maintain a development specific level ...
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Insufficient maintenance DNA methylation is associated with abnormal embryonic development
... Animal care followed the guidelines recommended by the Animal Care and Use Committee (ACUC) of the School of Medicine, Zhejiang University. Female ICR mice (six to seven weeks old) were synchronized and superovulated by ...
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Genomic Imprinting: Establishment, Maintenance and Stability of DNA Methylation Imprints
... Establishment, Maintenance and Stability of DNA Methylation Imprints Abstract Genomic imprinting is an epigenetic phenomenon in which genes are monoallelicaly expressed according to their ...
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DNA methylation and DNA methyltransferases
... genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the num- ber of protein-encoding mammalian genes was ...
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Long noncoding RNA mediated maintenance of DNA methylation and transcriptional gene silencing
... the maintenance of silencing is poorly ...the maintenance of transcriptional gene silencing in the one mega-base Kcnq1 imprinted domain in a transgenic mouse ...the maintenance of the silencing of ...
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Apoptosis and DNA methylation
... of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome ...linking DNA methyltransferases and methyl-CpG binding proteins to ...
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Aging and DNA methylation
... of DNA repair genes or anti-inflammatory ...in DNA methylation. DNA methylation patterns are shaped by two opposing processes of adding and removing a methyl group at pos- ition five of ...
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Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus
... allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 ...differential methylation of the H19 ICR is established during ...
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Annotating the genome by DNA methylation
... plant DNA. Nearest-neighbor experiments indicated that as opposed to animal DNA, methylation in plants was observed at additional non-symmetric C-containing dinucleotides, including CpC, CpA and ...a ...
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On DNA methylation: an introductory review
... for DNA methylation, namely DNA methyltran- ferases (DNMTs) and DNA ...by DNA methyltransferases in a reaction that involves base flipping, whereby a cytosine base is swung ...
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DNA Methylation and the Global Genome
... date, DNA methylation is the best characterized component of the epigenome, and therefore serves as a good example to illustrate the mechanics of the entire ...3 DNA methylation was noted ...
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The DNA methylation landscape in cancer
... the DNA demethylation process has prompted interest in its role in maintaining promoter CpG islands in the unmethylated state in normal ...quent DNA demethylation, suggesting that 5hmC is a stable ...
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DNA methylation of the POMC gene
... these methylation patterns are most likely established during embryogenesis before the deviation of the germ layer cell fates or are directly transmitted and preserved from the parental germ ...its ...
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Dnmt3L Antagonizes DNA Methylation at Bivalent Promoters and Favors DNA Methylation at Gene Bodies in ESCs
... of DNA methylation is not required for ESC maintenance, but it is necessary for the correct differentiation of ...the methylation of DNA of imprinted genes ( Hata et ...heavily ...
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Conformation-Selective Methylation of Geminivirus DNA
... single-stranded DNA genomes replicate in plant cell nuclei by using various double-stranded DNA (dsDNA) intermediates: distinct open circular and covalently closed circular as well as heterogeneous linear ...
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DNA base flipping analytical pipeline
... Abstract DNA base modifications and mutations are observed in all genomes throughout the kingdoms of ...base flipping mechanism to access their ...flip DNA bases to modify or remove them, we ...
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Flipping DNA to Generate and Regulate Microbial Consortia
... low flipping rates, genetic drift through random plasmid segregation will lead to a single arrangement becoming fixed between successive flipping ...achievable DNA flipping rates, requiring ...
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On the Analysis of DNA Methylation
... with DNA, then the DNA isolated with the molecule of interest can be sequenced to show where in the genome that molecule was associating with ...of DNA-binding ...that DNA is packaged ...
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DNA Methylation Analyses
... genomic DNA (500 ng) prepared from HeLa cells with a FastPure® DNA Kit, yielding 20 µl of treated genomic DNA ...genomic DNA was used as the ...CpG methylation results were analyzed ...
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