DNA minor groove
Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A
... polyanion DNA duplex upon ligand ...that minor groove recognition by small molecules can be enthalpically or entropically driven or both and that the ther- modynamic signature of MGBs is highly ...
12
Ranking ligand affinity for the DNA minor groove by experiment and simulation
... the DNA minor groove it has become possible to develop tailored approaches to drug ...with DNA specificities and affinities comparable to DNA-binding proteins and have allowed ...
13
Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove
... the DNA minor groove and classical small molecule DNA binders including Hoechst 33258 [1-234567] berenil [8,9] netropsin [10] distamycin A [11,12] and their derivatives ( ...peptide ...
37
Synthesis a novel DNA minor groove binding agents by bis benzimidazole
... with DNA. The CT-DNA solution (10 mM) was titrated against compound 8 in ...of DNA-compound 8 complex in the 258 nm ...with DNA minor ...
5
Synthesis of New Series of Bis Benzothiazole Derivatives as DNA Minor Groove Binding Agents
... Based on these structural studies, molecular modelling has suggested to us that compound 5 could effectively bind into the DNA minor groove (Figure 1). Then, a series of derivatives with a ...
6
Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli
... In the past, protein expression has been analyzed through mRNA studies. However, it was later shown that mRNA content does not correlate with protein con- tent as mRNA is not always translated into protein [16-19]. On ...
9
Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours
... of DNA cross-linking was observed in tumour cells at 2 h, consistent with the rapid formation of SG2000-induced cross-links observed in the LMeC cell line in vitro ...for DNA ICL at the same time points as ...
16
Comparative effects of A.T and G.C sequence selective DNA minor groove binding agents
... of DNA cleavage over a wide range of ligand ...involving minor groove binders and DNA processing enzymes demonstrate inhibition of the proteins, there are some reports of an increase in enzyme ...
227
2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model
... of DNA is the anti-parallel helix where the major and minor grooves provide sites for sequence-selective binding of proteins and small ...double-stranded DNA (dsDNA) sequences by transcription ...
24
DNA minor groove binders-inspired by nature
... Two molecules of this compound bind side-by-side in the minor groove however, MGBs containing one or more heterocyclic rings other than pyrrole 100 because of the bulky “isopropyl” of th[r] ...
33
Shape selective recognition of the DNA minor groove by hairpin polyamides
... Table 3.1A Observed equilibrium association constants for 1-6……………...……63 Table 3.1B Normalized equilibrium association constants for 1-6…………………63 Table 3.2 Normalized fluorescent intensities for 1-6 with DNA ...
18
Racial Disparity in Social Spatiality: Usage of National Parks and Opera Attendance
... The DNA minor groove is one of the most successful and attractive targets for drug design and development ...the minor groove of DNA present successful and effective classes of ...
193
Protein and drug interactions in the minor groove of DNA
... acceptors, DNA minor groove atoms A1 and A2 in an Acceptor ...the DNA acceptor A2 was estimated by the binding site position in each motif (Table 3) and the system D ...
10
Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition
... the DNA double-helix structure in 1953 by Watson and ...with DNA binding drugs, at least in part, are directly linked to their relatively weak DNA sequence targeting ...in DNA-targeted drug ...
9
Dinuclear polypyridyl ruthenium(II) complexes as stereoselective probes of nucleic acid secondary structures
... unique DNA sequence in the human genome would require an incredibly complex drug able to recognise a sequence of some 15-16 bases † ...polyamide minor groove binders such as netropsin and derivatives ...
171
Site-specific interactions of JBP with base and sugar moieties in duplex J-DNA - Evidence for both major and minor groove contacts
... “free” DNA population, ...major groove resulted in the greatest interference with JBP ...major groove was determined as described in “Experimental ...of DNA that is either bound (B) or unbound ...
8
Combined theoretical and computational study of interstrand DNA guanine–guanine cross linking bytrans [Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans [Pt(N3)2(OH)2(pyridine)2]
... ‘local’ region immediately around the Pt center. The AMBER94 force field (in MOE format) and the LFMM parameter file are provided in the Supporting Information (files SF1 and SF2). For Sim1 and Sim2, the ...
39
Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives
... and DNA for docking simulations was done by removing the crystallized ligand, water molecules, and cofactors in the Discovery Studio ...and DNA retained the rigid structure during molecular docking simula- ...
23
Repair of DNA interstrand cross-links induced by anticancer agents in mammalian cells
... Although the trans isomer of cisplatin, transplatin has no anti-tumour activity, it also binds to DNA but forms a spectrum of DNA-adducts distinct from that of cisplatin. Therefore, many studies have ...
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