DNA Mutations
SCID mice containing muscle with human mitochondrial DNA mutations An animal model for mitochondrial DNA defects
... Our approach to an animal model is very different from that of Jenuth et al. (25) who created a mouse which was het- eroplasmic for a rodent polymorphism by the electrofusion of the cytoplast of one zygote type with a ...
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Simple, Sensitive and Accurate Multiplex Detection of Clinically Important Melanoma DNA Mutations in Circulating Tumour DNA with SERS Nanotags
... Sensitive and accurate identification of specific DNA mutations can influence clinical decisions. However accurate diagnosis from limiting samples such as circulating tumour DNA (ctDNA) is ...
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Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas
... Mitochondrial DNA mutations in parathyroid adenomas tend to affect Complex I genes more often than other tumor types and more often then expected by chance ...D-loop mutations appear to be ...
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Identification of additional mitochondrial DNA mutations in canine mast cell tumours
... The obtained nucleotide sequences were subjected to bioinformatics analyses in order to determine muta- tion and polymorphic sites within the mtDNA frag- ment of each sample (DNA Baser Sequence Assembler v 3.2). ...
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Aspects of mitochondrial DNA mutations in relation to human male fertilising potential
... The very tight coupling between mitochondrial energy production and motility, and between motility and fertilising potential suggests that if deleterious mtDNA mutations were present wit[r] ...
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Large-scale automated isolation of Escherichia coli mutants with thermosensitive DNA replication (colony morphology/dna mutations)
... Incorporation of radioactive leucine (a measure of protein synthesis) and radioactive thymine (a measure of DNA synthesis) at the restrictive temperature (410) by three representative dn[r] ...
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Correlational study on mitochondrial DNA mutations as potential risk factors in breast cancer
... germline mutations of mtDNA. We found 32 site mutations associated with breast cancer, including 25 newly discovered ...32 mutations were found to have a negative correlation probability with breast ...
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Cell-free DNA mutations as biomarkers in breast cancer patients receiving tamoxifen
... Bio-informatics for variant detection and evaluation Raw data analyses, base calling and alignment were performed using Torrent Suite v4.0. Somatic low stringency filtering was applied in Variant Caller v4.16 (VC) to ...
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Mitochondrial DNA mutations in human colonic crypt stem cells
... Examples of frameshift mutations within cytochrome c oxidase structural genes associated with cytochrome c oxidase deficiency. (a) Sequencing electropherogram detailing a region of COIII containing a short, poly-C ...
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Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice
... and DNA damage ...induced DNA mutations in the mouse lungs [12, ...of DNA damage, such as gene mutation and DNA strand break formation, are important parts of evaluation and assessment ...
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Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
... line mutations in DNA-repair genes, we analyzed exome data compiled from 53,105 persons in- cluded in the Exome Aggregation ...deleterious DNA-repair gene mutation being present in men with ...
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The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway.
... SRS2 suppresses the DNA repair but not the UV mutagenesis and sporulation defects of the rud6A mutation: rad6 mutants are defective in DNA repair, induced mutagenesis a[r] ...
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Mutations in two cysteine-histidine-rich clusters in adenovirus type 2 DNA polymerase affect DNA binding.
... DISCUSSION The results presented above suggest that each of the two Cys-His clusters in Ad Pol may be involved in the DNA binding, but that each of these regions may play a different rol[r] ...
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Mutations That Increase DNA Binding by the Processivity Factor of Herpes Simplex Virus Affect Virus Production and DNA Replication Fidelity
... and DNA are critical for viral DNA ...of DNA binding in vitro, have indicated that the positively charged back surface of UL42 interacts with ...increased DNA binding by UL42 mutations, ...
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DNA identification by pedigree likelihood ratio accommodating population substructure and mutations
... (LR)s in the absence and presence of mutation are usually < 0.1. Clearly, mutation has a limited effect on the LR ratio, because of the relatively low probability of mutation in a single case scenario. Often LRs with ...
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Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.
... that mutations in both the DNA-binding and transcriptional activation domains of v-Myb are required for transformation of rapidly growing monoblasts rather than more slowly growing ...these mutations ...
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Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus.
... Isolation of mutations in nuclear genes that affect the rate of DNA escape and migration from mito- chondria to the nucleus: A mutant screen designed to isolate muta[r] ...
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Mutations in DNA Binding and Transactivation Domains Affect the Dynamics of Parvovirus NS1 Protein
... different DNA binding functions of the CPV NS1 ...with mutations at one, or both, of the lysines in the B= motif (K470A, K472A, or ...the DNA binding mutations, the transactivation activ- ity ...
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Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping
... The prospective multicenter study was conducted to analyze EGFR mutations in plasma samples. Sixty patients with advanced NSCLC were recruited from 11 hospitals of the Korean Molecular Lung Cancer Group (KMLCG) ...
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Mutations in symbiotic effectiveness in Rhizobium trifolii caused by transforming DNA and other agents
... A strain of Rhizobium trvolii able to fix nitrogen in root nodules of clover plants lost its effectiveness when treated with deoxyribonucleic acid (DNA) from an ineffective strain..[r] ...
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