DNA repair genes polymorphisms
Detection of Polymorphisms of DNA Repair Genes (XRCC1 and XPC) in Prostate Cancer
... disease. DNA in most cells is regularly damaged by endogenous and exogenous ...damage repair pathways operate in mammals. Common polymorphisms in DNA repair genes may alter ...
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Polymorphisms in DNA repair pathway genes and <em>ABCG2</em> gene in advanced colorectal cancer: correlation with tumor characteristics and clinical outcome in oxaliplatin-based chemotherapy
... in DNA repair pathway and MDR-associated genes (XPA rs10817938, XPA rs2808668, XPC rs2607775, WRN rs1346044, ABCG2 rs2231142, and ABCG2 rs2622621) were selected for the present ...
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Role of genetic polymorphisms in dna repair genes (xrcc1, xrcc2, xrcc3, xrcc4, xrcc5, xrcc6, xrcc7) in head and neck cancer susceptibility in rural indian population: a hospital based case control study from south western maharashtra
... genetic polymorphisms of various genes, including those involved in DNA repair ...Human DNA repair mechanisms are known to protect the genome from DNA damage caused by ...
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Association of DNA repair gene polymorphisms with carcinoma prostate.
... common polymorphisms in genes giving rise to a low penetrance risk of disease ...that DNA adducts form in prostate tissue after exposure to environmental toxins ...the DNA from oxidative ...
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Original Article Association of single nucleotide polymorphisms of DNA repair genes in NER pathway and susceptibility to pancreatic cancer
... strand DNA-dependent ATPase and 5’-3’ DNA helicase activities and participates in DNA unwinding during NER [25, ...26]. Polymorphisms in the ERCC2 gene are thought to reduce the helicase ...
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<p>The Impact of the Genetic Polymorphism in DNA Repair Pathways on Increased Risk of Glioblastoma Multiforme in the Arab Jordanian Population: A Case–Control Study</p>
... Therefore, a meta-analysis and systemic review of exist- ing studies should increase the statistical power. In their meta-analysis, M Adel Fahmideh et al (2014) reviewed 27 studies examining 105 SNPs in 42 DNA ...
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G₂ chromosomal radiosensitivity in childhood and adolescent cancer survivors and their offspring
... susceptibility genes involved in coping with damage to the genome, then appropriate methods must be sought to identify ...multiple genes within the same DNA repair pathways and thus provide a ...
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Polymorphisms in RAD51 and their relation with breast cancer in Saudi females
... X-ray repair cross-complementing proteins 2 and 3 (XRCC2, XRCC3), Breast cancer genes 1 and 2 (BRCA1, BRCA2), and so on to form a complex that is essen- tial during double-strand break repair and ...
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Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer
... DSBs repair gene variants and ovarian cancer [7, ...(XRCC) genes are DNA repair genes. These genes are associated with the DNA damage processing and genetic stability ...
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Original Article Genetic polymorphisms of DNA repair enzymes in dilated cardiomyopathy
... the polymorphisms in DNA repair enzymes: 8-oxoguanine glycosylase-1 (OGG1), AP endonuclease-1 (APE1), DNA polymerase β (POLβ), X-ray cross-complementing group 1 (XRCC1) in the base excision ...
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DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
... of DNA repair genes is a hallmark of senes- cence [49], we saw a general trend of decreased expres- sion in mTBI brains compared to controls with 36 genes being significantly down-regulated ...
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The alterations of XRCC1 gene’s polymorphism with a different SNP is involved in breast cancer
... 14. Luo H, Li Z, Qing Y, Zhang S-H, Peng Y, Li Q, et al. Single nucleotide polymorphisms of DNA base-excision repair genes (APE1, OGG1 and XRCC1) associated with breast cancer risk in a ...
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The Influence of Gene Polymorphisms on Tobacco and Alcohol Induced Oral Cancer Risk
... genetic polymorphisms of tobacco and alcohol-related metabolic genes such as GSTM1, GSTT1, GSTP1, CYP1A1, CYP2E1 and DNA repair genes (XRCC1 194Trp, XRCC1 399Gln, and XRCC3 Met) ...
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Investigation of DNA repair genes in patients with obsessive-compulsive disorder
... impaired DNA repair mechanisms might be rendering the dopaminergic mesocortical path- way more susceptible to these environmental ...between DNA repair gene polymorphisms and ...
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Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
... The polymorphisms of genes encoding carcinogen-metabolizing enzymes (CYP family, NQO1, GST), enzymes involved in folate metabolism (MTHFR, MTRR, SHMT, TS), and DNA repair enzymes (RAD51, ...
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XRCC1 and XPDgenetic polymorphisms, smoking and breast cancer risk in a Finnish case control study
... both DNA repair pathways were ...studied DNA repair genes account for only a small part of the known genetic variations in these pathways and, therefore, most probably do not explain ...
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Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage.
... of DNA repair systems. Amongst these, the DNA base excision repair (BER) pathway constitutes the front- line defense against endogenously-generated DNA damage including DNA base ...
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Screening the yeast genome for new DNA repair genes
... plasmid repair assay, in which a DSB is generated within a region of a plasmid that is not homologous to chromosomal sequences; thus homologous recombination cannot be used to repair this ...DSB ...
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DNA Repair in Drosophila: Mutagens, Models, and Missing Genes
... of repair after P excision nor- mally begins with HR, perhaps in part because the 17 nt 39 overhangs left by transposase are likely to be a poor substrate for c-NHEJ (Beall and Rio 1997; Gloor et ...
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Synthesis of PLGA nanoparticles of tea polyphenols and their strong in vivo protective effect against chemically induced DNA damage
... procedure. DNA (100 µ g) was subjected to alkaline unwinding for 1 hour in a dark ...Further, DNA in the elutes was measured by taking absorbance at 260 nm, and strand breaks were calculated by using the ...
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