Dopamine neurons
Midbrain Dopamine Neurons Signal Belief in Choice Accuracy during a Perceptual Decision
... of dopamine, as well as prediction errors in perceptual decision tasks of the type described here ...for dopamine responses under perceptual uncertainty is decision ...the dopamine prediction errors, ...
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Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease
... striatal dopamine release after am- phetamine challenge [33, 34], and this may have been more successful in differentiating the high-TH and low- TH ...of dopamine biosyn- thesis and was used for long-term ...
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Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons
... DA neurons are responsible for a variety of firing patterns in vivo and in vitro through the introduction of pharmacological ...Midbrain dopamine neurons have a very high depolarizing threshold (-33 ...
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Coordination Mechanism in Dopamine Neurons of the Substantia Nigra Pars Compacta and Norepinephrine Neurons of the Locus Coeruleus
... the dopamine neurons of the substantia nigra pars compacta and the norepinephrine neurons of the locus ...these neurons that have a large number of axon branches and synapses appears to have ...
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In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1
... in the developing VM (Sakurada et al., 1999), these findings suggest that the in vitro generation of DA neurons from VM-NPCs is induced by endogenous Nurr1. When we compared Nurr1 levels in individual cells by ...
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Multiple roles of β catenin in controlling the neurogenic niche for midbrain dopamine neurons
... DA neurons (Andersson et ...DA neurons from stem cells and with which these neurons engraft has been low, suggesting that additional mechanisms, such as signals from the microenvironment of DA ...
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Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons
... DA neurons dur- ing development and ...DA neurons express detectable levels of VGLUT2 in the ...DA neurons expressed a reporter indicative of past VGLUT2 ...DA neurons express VGLUT2 early in ...
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The Effects of Zinc and Other Divalent Cations on M Current in Ventral Tegmental Area Dopamine Neurons
... tial between the pipette solution and the HEPES-buffered solution was estimated to be 5 mV [23] and the results have been corrected by this amount. Membrane currents and voltage were filtered at 1 kHz by a −3 dB 4-pole ...
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PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
... A gender-balanced cohort of young adult PGC1α-KO mice was co-injected in the SNpc with the optimized AAV2/6 vector encoding aSyn (1 × 10 7 TU), together with a control non-coding vector (5 × 10 6 TU). Six months ...
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dopamine neurons affect individual risk for sporadic Parkinson’s
... Fig. 1. Natural variation in the number of pigmented neurons in healthy human. Four studies employing stereological quantification of the number of nigral pigmented neurons (Pakkenberg et al., 1991; Ma et ...
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Time representation in reinforcement learning models of the basal ganglia
... midbrain dopamine neurons: response to reward increases linearly with the logarithm of the stimulus- reward interval, consistent with the idea that prediction errors are being computed with respect to a ...
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Stimulus representation and the timing of reward prediction errors in models of the dopamine system
... of dopamine neuron behavior, these reinforcement-learning models have not dealt adequately with situations when reward timing is ...in dopamine activity are modulated by the magnitude of negative ...
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Alterations des fonctions de reproduction chez les souris males deficientes en recepteur aux estrogenes
... : Disruption of the estrogen receptor gene inter- feres with sexual differentiation of dopamine neurons in the peoptic region of the mouse.. VALE W., BILEZIKJIAN L., R[r] ...
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Combined Diffusion Tensor Imaging and Apparent Transverse Relaxation Rate Differentiate Parkinson Disease and Atypical Parkinsonism
... PD is marked by the loss of dopamine neurons in the substantia nigra SN.3 MSA is characterized neuropathologically by glial and neuronal cytoplasmic inclusions in many basal ganglia and [r] ...
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Deep brain stimulation of different pedunculopontine targets in a novel rodent model of parkinsonism
... nigrostriatal dopamine neurons that mimics human pathophysiology, and investigated the effect of DBS at different PPTg locations on gait and posture using a wireless device that lets rats move freely while ...
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Journal of Applied Pharmaceutical Science
... protected dopamine neurons and their ...of dopamine neurons and produced much more attenuation in neurite loss compared to rescuing only 17% of dopamine neurons and producing ...
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Ghrelin Regulates Energy Homeostasis Through Discrete Central and Peripheral Signaling Mechanisms
... mesocorticolimbic dopamine system, regulates feeding and body weight by reinforcing behaviors that result in food ...mesocorticolimbic dopamine neurons to regulate food intake, body weight, and ...
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Insights into Parkinson’s disease from computational models of the basal ganglia
... in dopamine concentration arise because dopamine neurons deviate around their constant spontaneous activity with brief bursts or pauses (Figure ...of dopamine neurons in the lateral ...
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EFFECTS OF DOPAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORM ALIN TEST
... GABAergic neurons in the rat neostriatum receive dopaminergic ...nigral neurons. It also inhibits ftring of dopamine neurons in the ventral tegmental area28 and reduces the turnover of brain ...
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Pharmacological strategies for Parkinson’s disease
... dopaminergic neurons, since the ability to transform L-DOPA to dopamine is altered with the progression of dopamine ...3 dopamine receptor agonists have ...
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