dorsal horn
Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain
... Although our immunostaining results showed the pre- dominant expression of CCR2 in neurons, the cellular localization of CCR2 in the central nervous system is heavily debated. An early immunohistochemical study shows ...
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Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord
... BrdU labeling and detection by immunocytochemistry Pregnant female mice derived from timed matings between Lmx1b or Rnx or Drg11 heterozygous mice were given a single intraperitoneal injection of BrdU (5 mg/ml solution ...
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Key role for spinal dorsal horn microglial kinin B1receptor in early diabetic pain neuropathy
... spinal dorsal horn microglia is a crucial component of STZ-induced tactile allodynia which is partly mediated by the extracellular signal-regulated protein kinase sig- naling ...
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Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn
... Ptf1a is present in the developing nervous system We used recombination-based lineage tracing in vivo to characterize regions of the nervous system derived from Ptf1a- expressing cells. The mouse strain Ptf1a Cre/+ , ...
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<p>Systemic Injection of Thalidomide Prevent and Attenuate Neuropathic Pain and Alleviate Neuroinflammatory Response in the Spinal Dorsal Horn</p>
... Our results showed that the PWMT of affected sides remarkably decreased after L5 ligation and peaked at 3 days postoperation and lasted 14 days. In the present study, Tha was used as a drug intervention. A single ...
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MHC-I promotes apoptosis of GABAergic interneurons in the spinal dorsal horn and contributes to cancer induced bone pain
... the dorsal horn of sham, tumor, tumor+NC-LV, tumor+RNAi-LV rats on day 14 post tumor cells ...the dorsal horn of different ...the dorsal horn of different groups post-sarcoma ...
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<p>G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury</p>
... receptors. 3,4 A well-established example is opioid-induced analgesia which involves GIRK channels acting as down- stream effectors. 5 – 8 In addition, GIRK channels are known to mediate the inhibitory effects of many ...
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Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib
... Reduction of SIRT1 upregulated NALP1 expression and participated in bortezomib-induced mechanical allodynia Next, we found that the dorsal horn SIRT1 protein ex- pression was significantly decreased on days ...
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Development of opioid analgesic systems in the rat
... firing dorsal horn neurones (Fields et a l 1977; Guillbaud et ...1986). Dorsal horn neuronal firing has been shown to be uninfluenced by DLF stimulation before P9 whilst between P12 and P I 8 ...
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Activation of spinal nociceptin receptors induces cardiovascular depression and antinociception in an independent manner in mice
... Results: Positive immunoreactivity against NOP colocalized with neurons in the IML and superficial dorsal horn layers of thoracic spinal cord. Intrathecal administration of nociceptin (1, 2, or 5 nmol) ...
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The effect of exercise frequency on neuropathic pain and pain-related cellular reactions in the spinal cord and midbrain in a rat sciatic nerve injury model
... Notes: graphs indicate the ratios of positive staining for iba1 (N), gFaP (O), MOR (P), and BDnF (Q) in the spinal dorsal horn at 1 week after cci. iba1 and gFaP immunoreactivity in the ipsilateral side ...
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Actions of neuropeptides on mouse spinal neurones in culture
... 5 5 Both met - and leu -enkephalin evoked inhibitory responses from neurones in the dorsal horn of the cat spinal cord,... Zieglgansberger and Tulloch [1979]..[r] ...
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WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms
... Background: Targeting the endocannabinoid system has emerged as an effective strategy for the treatment of inflammatory and neurological diseases. Unlike the inhibition of the principal 2-arachidonyl glycerol (2-AG) ...
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The survival and growth of sensory neurons following peripheral nerve injury
... that dorsal horn neurons receiving lamina II input misinterpret low threshold innocuous input as noxious, meaning that A-fibre sprouting may be anatomical substrate for mechanical ...
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Immediate effects of spinal manipulation on thermal pain sensitivity: an experimental study
... The finding that SMT may have a local hypoalgesic effect specific to C-fiber mediated input for asymptomatic sub- jects adds to the previous literature and provides direction for future study. First, this experiment ...
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Periaqueductal grey EP3 receptors facilitate spinal nociception in arthritic secondary hypersensitivity
... strength produces LTP at C-fiber synapses only when descending controls are disrupted (Liu et al., 1998). C-nociceptive drive from the primary injury site may affect the spinal processing of A-nociceptor inputs from the ...
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Diabetes induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain
... (Sigma-Aldrich, Poole, UK; 45 mg kg −1 ) at 120 mmHg pressure. Two minutes after infusion, 0.2 mL arterial blood was withdrawn, followed by subsequent 0.1 mL withdrawals every 15 min for 2 h. After 2 h, 0.2 mL blood was ...
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TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
... Central sensitization has been implicated in itch hypersensi- tivity. For example, scratching is greatly potentiated after loss of Bhlhb5-expressing inhibitory interneurons in the dorsal horn (23). Central ...
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Development of Spinal Neuronal Hyperexcitability and Structural Plasticity after Cervical Facet Injury: Implications for Modulating Persistent Pain
... of dorsal horn neurons by primary afferent firing, augmenting the effects of noxious peripheral stimuli, like excessive stretch of the facet ...spinal dorsal horn, and to evaluate the role of ...
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Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
... Representative images of total (TAU5, A ) and phosphorylated tau (AT8, A ; AT100 and AT180, B ) immunofluorescence in the spinal cord (dorsal horn), cortex (layers I-II), and hippocampus[r] ...
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