dosage compensation
Study of Dosage Compensation in Drosophila
... of dosage compensa- male and female, there is a regulatory mechanism of tion in Drosophila receives wide acceptance, direct ex- dosage compensation operating such that the resulting perimental data ...
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Chromatin That Guides Dosage Compensation Is Modulated by the siRNA Pathway in Drosophila melanogaster
... Soruco, M. M., J. Chery, E. P. Bishop, T. Siggers, M. Y. Tolstorukov et al., 2013 The CLAMP protein links the MSL complex to the X chromosome during Drosophila dosage compensation. Genes Dev. 27: 1551 – ...
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Dosage compensation and sex-specific epigenetic landscape of the X chromosome in the pea aphid
... [2–5]. Dosage compensation mechanisms are thought to have evolved to correct such disequilib- ...complete dosage compensation in other male heterogametic insect species ...partial ...
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Diverse developmental strategies of X chromosome dosage compensation in eutherian mammals
... Early embryonic development of eutherian mammals is closely linked with dosage compensation of X chromosome genes. Mam- malian X and Y chromosomes differ significantly in gene content and play a key role in ...
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Defects in dosage compensation impact global gene regulation in the mouse trophoblast
... A strict requirement for dosage compensation during embryonic development might underlie upregulation of the second, wild-type Xist allele. A recent model proposes the action of a putative X-linked ...
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The C. elegans dosage compensation complex mediates interphase X chromosome compaction
... in dosage compensation we utilized chromosome-paint 3D fluo- rescent in situ hybridization (FISH) to measure the vol- umes of chromosome X and I territories in wild type and DCC-depleted hermaphrodite and ...
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Mammalian X chromosome inactivation evolved as a dosage compensation mechanism for dosage sensitive genes on the X chromosome
... gene dosage during sex-chromosome evolution are not expected to impact on all genes equally, and should have greater conse- quences for dosage-sensitive ...be dosage-sensitive — expression of ...
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Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers
... chromosome-wide dosage compensation mechanism in ...functional dosage compensation mechanism that is far more effective than the partial, localized dosage compensa- tion recorded in ...
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Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers
... chromosome-wide dosage compensation mechanism in ...functional dosage compensation mechanism that is far more effective than the partial, localized dosage compensa- tion recorded in ...
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Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains
... specific dosage compensa- tion has canonical and non-canonical ...canonical dosage compensation is active in repressive domains, the MSL complex should occupy those ...
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The Caenorhabditis elegans Dosage Compensation Machinery Is Recruited to X Chromosome DNA Attached to an Autosome
... the dosage compensation complex on hermaphrodite X chro- mosomes in ...sage compensation by localizing a protein complex composed of DPY- 26, DPY-27, DPY-28, and MIX-1 to both hermaphrodite X chromo- ...
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The Drosophila Dosage Compensation Complex Binds to Polytene Chromosomes Independently of Developmental Changes in Transcription
... OSAGE compensation in Drosophila represents a unique example of chromosome-specific upregu- lation of genetic activity, which results in the equaliza- tion of levels of X chromosome products in homo- and ...
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Modulation of MSL1 Abundance in Female Drosophila Contributes to the Sex Specificity of Dosage Compensation
... In summary, females prevent MSL1 accumulation by two distinct SXL-dependent mechanisms. The cluster of polyuridine tracts in the 39 UTR is necessary for a small reduction in MSL1 synthesis, presumably by direct SXL ...
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Trade-off Between Selection for Dosage Compensation and Masculinization on the Avian Z Chromosome
... dosage compensation with no masculinization, Z-linked expression in the youngest stratum is predicted to reflect the ratio of expression from two copies in males to only one in ...of dosage ...
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Global analysis of X-chromosome dosage compensation
... the dosage-compensation systems in Caenorhabditis elegans and mammals, which are based on reducing X-chromosome expression in XX;AA cells ...the dosage-compensation model equilibrates ...
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Dosage compensation is less effective in birds than in mammals
... achieve dosage compensation suggests that effective dosage compensation is critical, and perhaps ubiquitous, among species with heteromorphic sex chromo- somes ...[3-5]. Dosage ...
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ANALYSIS OF THE DOSAGE COMPENSATION OF A SPECIFIC TRANSCRIPT IN DROSOPHILA MELANOGASTER
... Dosage compensation of Sgs-4: In order to determine the sensitivity of our RNA assay, we performed a series of experiments designed to confirm the dosage compensatio[r] ...
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Drosophila dosage compensation: a complex voyage to the X chromosome
... they dosage compensated by long-range effects of MSL action, by an MSL-independent mechanism, or do they escape dosage compensation altogether? Nearly all transcribed genes on the X chromosome are ...
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Dosage Compensation in Drosophila—a Model for the Coordinate Regulation of Transcription
... males was RNase sensitive (Richter et al. 1996); MLE might, therefore, be lost during the preparation of nuclear extracts. It is worthwhile to note that this observation led Richter and collaborators to suggest that a ...
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A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster
... affects dosage com- pensation, we asked whether reduction of Ago2 rescued females that inappropriately deploy the dosage compensa- tion machinery, leading to toxic overexpression of both X ...induces ...
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