Double knockout (DKO)
Hepatic caveolin 1 is enhanced in Cyp27A1/ApoE double knockout mice
... ) double knockout mice (DKO) fed a western diet failed to develop ...and DKO mice were fed a western diet for 2 ...of DKO mice and negatively correlated with plaque surface (P < ...
11
Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice
... -/- double knockout mice on a stan- dard diet were (Charles Rivers Wiga, Sulzbach, Ger- many) euthanized after 80 (n = 6) weeks with a fatal dose of inhalative ...
8
Morphological characterization of the AlphaA- and AlphaB-crystallin double knockout mouse lens
... the double knockout ...alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where ...
11
Severe facial clefting in Insig deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
... Insig-1 and Insig-2 are regulatory proteins that restrict the cholesterol biosynthetic pathway by preventing proteolytic activation of SREBPs and by enhancing degradation of HMG-CoA reductase. Here, we created ...
11
Cdk2 and Cdk4 cooperatively control the expression of Cdc2
... We recently generated Cdk2/Cdk4 double knockout (DKO) mice and for the first time we observed reduced Rb phosphorylation in vivo and in vitro [7]. The decrease of Rb phosphorylation is progressive ...
6
Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice
... Presenilins associate with Aph1, Pen2 and Nicastrin in a large complex that mediates intramembranous, " γ -secre- tase" [1] proteolysis of a variety of type-I membrane pro- teins, including Notch, APP, ...
11
Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma
... Dicer-Pten double knockout (Dicer-Pten DKO) developed primary tumors, intriguingly, from the fallopian tube ...Dicer-Pten DKO mouse tumor cells contributable by each gene ...Dicer-Pten ...
10
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood cerebrospinal fluid barrier
... Mdr1a/Mdr1b double-knockout (DKO) mice to study the contribution of Mrp1 to the tissue distribution and pharmacokinetics of ...and DKO mice cannulated for cerebrospinal fluid ...
8
Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle
... Dihydroethidium; dko : Dystrophin/utrophin double knockout; DMD: Duchenne muscular dystrophy; DNAJC19: Mitochondrial import inner membrane translocase subunit TIM14; DNPH: 2, ...
13
The α1A/C and α1B adrenergic receptors are required for physiological cardiac hypertrophy in the double knockout mouse
... Cardiac growth during development occurs in two phases, initially by myocyte hyperplasia, but primarily by myocyte hypertrophy after the early postnatal peri- od. Postnatal cardiac hypertrophy is a normal physio- logical ...
10
Double and multiple knockout simulations for genome-scale metabolic network reconstructions
... networks, double knockout analysis required solving 5 to 20 times as many LPs than single knockouts, ...full double knockout simulation is comparable to iter- ating over all reactions r ∈ Rep, ...
10
Lymphocytes are important in early atherosclerosis
... LDL-R knockout and RAG1/LDL-R double knockout mice identified important ...RAG1/LDL-R double knockout lesions were 54% smaller than LDL-R knockout lesions (P < ...RAG1/LDL-R ...
10
The LEM Domain Proteins Emerin and LAP2α Are Dispensable for Human Immunodeficiency Virus Type 1 and Murine Leukemia Virus Infections
... emerin knockout, LAP2 ␣ knockout, or emerin and LAP2 ␣ double knockout mice to be comparable in infectivity to wild-type littermate-derived MEFs, indicating that both emerin and LAP2 ␣ were ...
9
Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons
... ephrin-A2/A5 double knockout mice, VCN axons terminated in ...ephrin-A2/A5 double knockout mice also displayed numerous terminations in MNTBi, indicating significant errors in axon ...single ...
10
Developmental functions of the dynamic DNA methylome and hydroxymethylome in the mouse and zebrafish: similarities and differences
... −/− double knockout zebrafish die during the larval period (Li et ...tet2/tet3 double mutant zebrafish suggest that Tet proteins play very specific roles during lineage specification and ...
15
Learning the language of cell cell communication through connexin channels
... The first disease to be associated with connexin mutations was the X-linked form of Charcot-Marie-Tooth (CMTX). One of the puzzling aspects of CMTX remains the exquisite restriction of symptoms to the peripheral nervous ...
5
Conditional ablation of Notch signaling in pancreatic development
... Notch1/Notch2 knockout mice over an observation period of 18 months (Siveke et ...in double-knockout pancreata, Notch1 and Notch2 protein and transcripts were decreased to less than 10%, as analyzed ...
9
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers
... Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during postnatal development, and then are maintained in an undifferentiated quiescent state in adult ...
11
Cardiac specific ablation of ARNT leads to lipotoxicity and cardiomyopathy
... Hif1a knockout leads to mild cardiac hypertrophy with reductions in contractility, vascularization, and high-energy phos- phate content (33), but no evidence of lipid ...inducible knockout of Hif1a after ...
13
Myricetin and Hesperidin Inhibit Cerebral Thrombogenesis and Atherogenesis in Apoe / and Ldlr / Mice
... Flavonoids have been reported to possess strong antioxidant activities that moderate endothelial dysfunction and demonstrate protective effects on car- diovascular disease. Our previous studies confirmed that flavonoids, ...
12