Double strand break
Telomere Dysfunction Triggers Palindrome Formation Independently of Double-Strand Break Repair Mechanisms
... ABSTRACT Inverted chromosome duplications or palindromes are linked with genetic disorders and malignant transformation. They are considered by-products of DNA double-strand break (DSB) repair: the ...
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Testing Predictions of the Double-Strand Break Repair Model Relating to Crossing Over in Mammalian Cells
... meiotic double-strand breaks ...The double-strand break repair (DSBR) model is currently accepted as a paradigm for acts of DSB repair that lead to crossing ...
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Properties of Natural Double-Strand-Break Sites at a Recombination Hotspot in Saccharomyces cerevisiae
... for double-strand-break (DSB) site recognition? Do naturally oc- curring DSB sites compete with each other in meiotic recombination? What role does the sequence located at the sites of DSBs play? In ...
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DNA Double Strand Break Repair and its Association with Inherited Predispositions to Breast Cancer
... could barely be tolerated and most resulted in severe symptoms that culminated in the early demise of the affected individual. Such conditions include Nijmegen Breakage Syndrome, Ataxia Telangiectasia, Fanconi Anaemia, ...
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Strand Invasion and DNA Synthesis From the Two 3′ Ends of a Double-Strand Break in Mammalian Cells
... Analysis of the crossover products recovered following transformation of mammalian cells with a sequence insertion (“ends-in”) gene-targeting vector revealed a novel class of recombinant. In this class of recombi- nants, ...
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The role of homologous recombination in mitotic and meiotic double-strand break repair
... Chapter 1 of this thesis introduces one of the most genotoxic lesions: the DNA double-strand break (DSB), which affects both DNA strands of the double helix. DSBs can be induced by ionizing ...
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Double-Strand Break Repair in Tandem Repeats During Bacteriophage T4 Infection
... T HE efficient repair of double-strand DNA breaks ken ends. Transformation of linear dimer plasmids into (DSBs) is of vital importance in virtually every or- E. coli can result in monomer circular ...
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Evidence for conservative (two-progeny) DNA double-strand break repair.
... Intramolecular double-strand break repair in the RecE pathway (in a recBC sbcA strain): As our aim is in demonstration of intramolecular recombination and, therefore, cons[r] ...
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Mechanisms of Double-Strand-Break Repair During Gene Targeting in Mammalian Cells
... In the present study, the mechanism of double-strand-break (DSB) repair during gene targeting at the chromosomal immunoglobulin m-locus in a murine hybridoma was examined. The gene-targeting assay ...
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Differential Usage of Alternative Pathways of Double-Strand Break Repair in Drosophila
... Competition between pathways: One common theme in the experiments reported here is the tendency for pathway usage frequencies to change in a compensatory fashion relative to each other. Increased usage of one pathway ...
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Roles for the Rad27 Flap Endonuclease in Mitochondrial Mutagenesis and Double-Strand Break Repair in Saccharomyces cerevisiae
... ABSTRACT The structure-speci fi c nuclease, Rad27p/FEN1, plays a crucial role in DNA repair and replication mechanisms in the nucleus. Genetic assays using the rad27-D mutant have shown altered rates of DNA recombination, ...
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Mitotic Gene Conversion Tracts Associated with Repair of a Defined Double-Strand Break in Saccharomyces cerevisiae
... defined double-strand break was used to initiate reciprocal loss of heterozygosity between diverged homologs of chromosome IV in Saccharomyces cerevisiae ...during strand exchange (heteroduplex ...
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Coordination of DNA Ends During Double-Strand-Break Repair in Bacteriophage T4
... of double-strand-break repair (DSBR) proposes that each end of a double-strand break (DSB) is repaired independently by initiating extensive semiconser- vative DNA replication ...
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Incorporation of Large Heterologies Into Heteroduplex DNA During Double-Strand-Break Repair in Mouse Cells
... H OMOLOGOUS recombination represents a ma- potential to accommodate sequence heterogeneities in- jor pathway for the repair of chromosomal dou- cluding single-base-pair mismatches or unpaired multi- ble-strand ...
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Apparent Epigenetic Meiotic Double-Strand-Break Disparity in Saccharomyces cerevisiae: A Meta-Analysis
... for double-strand-break repair in WT yeast (Stahl and Foss ...initiating break. Extension of the invading strand enlarges the D-loop until enlargement is stopped, perhaps by annealing ...
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MTE1 Functions with MPH1 in Double-Strand Break Repair
... HO double-strand break (Figure 5). The HO double-strand break was induced by growth in galactose to induce expression of the HO endonuclease ...DNA double-strand ...
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The Effect of Gap Length on Double-Strand Break Repair in Drosophila
... We made use of a series of chromosomes in which the same P-element insertion is precisely juxtaposed with deletions of various sizes (P reston et al. 1996). These chromosomes, listed in Table 1, were formed by a pro- ...
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Double-Strand Break-Induced Recombination Between Ectopic Homologous Sequences in Somatic Plant Cells
... a double-strand break in script, Siegfried Salomon for discussions, Susanne Ko¨nig for sequence the recipient molecule (a), 39-single-strand overhangs are pro- analysis, and Petra Oswald and ...
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Distinct functions of BRCA1 and BRCA2 in double strand break repair
... Early studies on BRCA1 (208 kDa) and BRCA2 (384 kDa) led to the conclusion that the two proteins function together as part of a complex that acts directly in double- strand break (DSB) repair. First, ...
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Double-Strand Break-Induced Mitotic Intrachromosomal Recombination in the Fission Yeast Schizosaccharomyces pombe
... With DSB-induced extrachromosomal recombina- tion substrates in mammalian cells, one of the most striking differences is that nonhomologous recombina- tion (end-joining) [r] ...
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