Double Strand Break Repair
Evidence for conservative (two-progeny) DNA double-strand break repair.
... Intramolecular double-strand break repair in the RecE pathway (in a recBC sbcA strain): As our aim is in demonstration of intramolecular recombination and, therefore, cons[r] ...
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Incorporation of Large Heterologies Into Heteroduplex DNA During Double-Strand-Break Repair in Mouse Cells
... and repair of large (⬎1 kb) insertion/deletion (I/D) heterologies during double-strand-break repair (DSBR) was investigated using a gene-targeting assay that permits efficient recovery ...
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Differential Usage of Alternative Pathways of Double-Strand Break Repair in Drosophila
... Competition between pathways: One common theme in the experiments reported here is the tendency for pathway usage frequencies to change in a compensatory fashion relative to each other. Increased usage of one pathway ...
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Coordination of DNA Ends During Double-Strand-Break Repair in Bacteriophage T4
... of double-strand-break repair (DSBR) proposes that each end of a double-strand break (DSB) is repaired independently by initiating extensive semiconser- vative DNA ...
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DNA Double Strand Break Repair and its Association with Inherited Predispositions to Breast Cancer
... DNA repair mechanisms that include DNA mismatch repair, nucleotide excision repair, base excision repair and DNA double strand break ...
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Tying the loose ends together in DNA double strand break repair with 53BP1
... DNA repair of broken chromosomes by anchoring DNA ends in preparation for end processing and ligation by the NHEJ apparatus, an activity that can suppress ...DNA repair is intact, two distinct, essentially ...
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DNA double strand break repair enzymes function at multiple steps in retroviral infection
... One reason for the inconsistency between the GFP reporter assay and the sequence analyses, particularly in Mre11 and NBS1, may be that the frequencies of the abnormalities at the host-virus junctions were low. There- ...
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Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae
... A densitometric analysis of these data showed that in the wild-type strain (Figure 5a) the whole recombina- tion product (deletion plus gene conversion) repre- sented alm[r] ...
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The role of homologous recombination in mitotic and meiotic double-strand break repair
... and/or repair of DNA damage. However, the role for SUMO in the repair of DSBs may be rather ...and repair of damage and lead to reduced survival after ...
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Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis
... in double-strand cleavage to abort DNA exchange has not yet been formally ...permits repair of a DSB at stretches of homology greater than 550 bp following heteroduplex for- mation, assuming a ...
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Mechanisms of Double-Strand-Break Repair During Gene Targeting in Mammalian Cells
... In the present study, the mechanism of double-strand-break (DSB) repair during gene targeting at the chromosomal immunoglobulin m-locus in a murine hybridoma was examined. The gene-targeting ...
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Genetic and physical analysis of double-strand break repair and recombination in Saccharomyces cerevisiae.
... LACZ gene on a centromere-containing plasmid such that no functional @-galactosidase was produced. This construction also includes another promoterless copy of LACZ, containi[r] ...
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Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.
... Synthetic sensitivity of haploid 5-932 mutants to DNA damage: Our observations show that dominant-nega- tive alleles of RAD52 similarly suppressed the W and MMS sensitivi[r] ...
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A Test of the Double-Strand Break Repair Model for Meiotic Recombination in Saccharomyces cerevisiae
... The DSBR model, as modified to retain fully the 3‘- ended strands (absent mismatch correction), predicts that hDNA will be present on both DNA molecules that emerge from a[r] ...
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A Role for REV3 in Mutagenesis During Double-Strand Break Repair in Saccharomyces cerevisiae
... Spontaneous reversion of point mutations showed a greater REV3 dependence than reversion of frameshift mutations: We investigated the role of REV3 in sponta- neous reversio[r] ...
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Double-Strand Break Repair in Tandem Repeats During Bacteriophage T4 Infection
... on double-stranded ends and is thought to be active during the early part of T4 infections (Lipinska et ...the double mutant ITM-46 ⫺ resulted in a large accumulation of cleaved plasmid DNA, as well as the ...
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The Effect of Gap Length on Double-Strand Break Repair in Drosophila
... Our results provide strong evidence that homologous gap repair is a length-limited process, but other inter- pretations should be considered. In particular, note that the two chromosomes that produce gaps of 43 ...
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Distinct functions of BRCA1 and BRCA2 in double strand break repair
... BACH1 mutations have been identified in two out of 65 women with early-onset breast cancer [24], one of whom had a familial history of breast and ovarian cancer. Both individuals were normal for BRCA1 and BRCA2. One ...
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MTE1 Functions with MPH1 in Double-Strand Break Repair
... a double- strand break (Lazzaro et ...tel1D double mutant had a statis- tically evident increase in Mte1 foci, in both the absence and presence of phleomycin (P = ...
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Regulation of DNA Double-Strand Break Repair by
... Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in. 780[r] ...
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