double-strand DNA break
Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 Cleavage in Leishmania
... DNA polymerase is the key player in MMEJ in mammalian cells. The polymerase domain located at the C terminus of Pol is required in MMEJ for annealing the 3= overhangs and filling the gaps between broken ...
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MTE1 Functions with MPH1 in Double-Strand Break Repair
... the double-strand DNA break-inducing agent phleomycin (Figure ...known DNA repair, DNA replication, or checkpoint signaling proteins (Figure ...induced ...
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The Drosophila spn-D Gene Encodes a RAD51C-Like Protein That Is Required Exclusively During Meiosis
... in double-strand DNA break (DSB) repair enzymes, such as spn-B, activate a meiotic checkpoint leading to dorsal-ventral patterning defects in the egg and an abnormal appearance of the oocyte ...
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The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair
... in DNA repair, chromatin binding, RNA processing, gene transcription, DNA replication, and nucleolar function (Figure ...for DNA damage response and repair, several proteins that are known to ...
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DNA Double Strand Break Repair and its Association with Inherited Predispositions to Breast Cancer
... Mutations in BRCA1 account for the majority of familial aggregations of early onset breast and ovarian cancer (~70%) and about 1/5 of all early onset breast cancer families; in contrast, mutations in BRCA2 account for a ...
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DNA double strand break repair enzymes function at multiple steps in retroviral infection
... There are inconsistencies in previous reports regarding the roles of DNA repair enzymes in retroviral replication [38- 42]. This is partly because almost all of these studies were based on measuring the retroviral ...
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Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment
... of DNA-PKcsi [29, 30, 32] and HT [26, 27] separately, but the combination of both repair inhibitors, has not yet been ...and DNA-PKcsi. Furthermore, the possibility that HT and DNA-PKcsi could ...
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Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway
... prolonged DNA repair, and the expression of p53 protein; phosphorylation on serine 15 and 20 increased in combination with ...aggravated DNA damages and caused typical apoptotic cell death; as well the ...
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Incorporation of Large Heterologies Into Heteroduplex DNA During Double-Strand-Break Repair in Mouse Cells
... the double-strand-break-repair (DSBR) model efficiency similar to that of small I/D heterologies and (Szostak et ...duplex DNA (hDNA), and primes DNA repair synthesis, and meiotic ...
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Chemotherapeutic compounds targeting the DNA double strand break repair pathways: the good, the bad, and the promising
... The use of retroviral gene therapy using recombinant ade- novirus with mutant forms of the individual proteins in the MRN complex has shown promising results in vitro and in vivo. In human head and neck squamous cell ...
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Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic
... efficient DNA damage recognition, double strand break repair and evasion of ...different DNA damage recognition and repair pathways in the creation of a radioresistant MSC phenotype is ...
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Strand Invasion and DNA Synthesis From the Two 3′ Ends of a Double-Strand Break in Mammalian Cells
... vector-borne double-strand break ...involve strand invasion and DNA synthesis by both 3⬘ ends of the ...These DNA interactions are a central, predicted feature of the DSBR model ...
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Tying the loose ends together in DNA double strand break repair with 53BP1
... Because roughly one half of all tumors have wild-type p53 activity, one approach for activating and stabilizing p53 in tumor cells could involve disrupting the Mdm2-p53 inter- action. This would be expected to induce a ...
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Original Article Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan
... of DNA double strand break, showed that its expression was significantly increased in foci of BilIN, IPNB and invasive carcinoma as well as in non-neoplastic biliary epithelial cells of the ...
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Coordination of DNA Ends During Double-Strand-Break Repair in Bacteriophage T4
... addition. DNA was digested with AseI alone (odd-numbered lanes) or AseI plus HaeIII (even-numbered lanes), and plasmid bands were visualized using a probe for the regions of plasmid ...
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HOW MANY PROCESSED PSEUDOGENES ARE ACCUMULATED IN A GENE FAMILY?
... This observation suggests that a staggered double-strand break is created at the target site in the DNA, with subsequent replication creating duplicated repeats th[r] ...
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Capture of DNA Sequences at Double-Strand Breaks in Mammalian Chromosomes
... study double-strand break (DSB)-induced mutations in mammalian chromosomes, we transfected thymidine kinase (tk)-deficient mouse fibroblasts with a DNA substrate containing a recognition site ...
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Evidence for conservative (two-progeny) DNA double-strand break repair.
... Intramolecular double-strand break repair in the RecE pathway (in a recBC sbcA strain): As our aim is in demonstration of intramolecular recombination and, therefore, cons[r] ...
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DNA synthesis errors associated with double-strand-break repair.
... In contrast to the spontaneous revertants that were found equally on both chromosomes, it is remarkable that nearly all the revertants were on the chromosome that had th[r] ...
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Regulation of DNA Double-Strand Break Repair by
... Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in. 780[r] ...
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